Human DTL cDNA Clone Expression Plasmid – Cat# MBS1270451

DTL cDNA Clone – Denticleless Homolog (Drosophila) (Human)

Name: DTL cDNA Clone; Denticleless Homolog (Drosophila); Human; MyBioSource
Brand: MyBioSource
SKU: MBS1270451
Price: 235 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1270451

MBS1270451 is a cDNA clone targeting DTL. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

DTL, cDNA Clone

Full Product Name

DTL cDNA Clone

Product Gene Name

DTL cdna clone

Sequence

atgctcttca attcggtgct ccgccagccc cagcttggcg tcctgagaaa tggatggtct tcacaatacc ctcttcaatc ccttctgact ggttatcagt gcagtggtaa tgatgaacac acttcttatg gagaaacagg agtcccagtt cctccttttg gatgtacctt ctcttctgct cccaatatgg aacatgtact agcagttgcc aatgaagaag gctttgttcg attgtataac acagaatcac aaagtttcag aaagaagtgc ttcaaagaat ggatggctca ctggaatgcc gtctttgacc tggcctgggt tcctggtgaa cttaaacttg ttacagcagc aggtgatcaa acagccaaat tttgggacgt aaaagctggt gagctgattg gaacatgcaa aggtcatcaa tgcagcctca agtcagttgc cttttctaag tttgagaaag ctgtattctg tacgggtgga agagatggca acattatggt ctgggatacc aggtgcaaca aaaaagatgg gttttatagg caagtgaatc aaatcagtgg agctcacaat acctcagaca agcaaacccc ttcaaaaccc aagaagaaac agaattcaaa aggacttgct ccttctgtgg atttccagca aagtgttact gtggtcctct ttcaagacga gaatacctta gtctcagcag gagctgtgga tgggataatc aaagtatggg atttacgtaa gaattatact gcttatcgac aagaacccat agcatccaag tctttcctgt acccaggtag cagcactcga aaacttggat attcaagtct gattttggat tccactggct ctactttatt tgctaattgc acagacgata acatctacat gtttaatatg actgggttga agacttctcc agtggctatt ttcaatggac accagaactc taccttttat gtaaaatcca gccttagtcc agatgaccag tttttagtca gtggctcaag tgatgaagct gcctacatat ggaaggtctc cacaccctgg caacctccta ctgtgctcct gggtcattct caagaggtca cgtctgtgtg ctggtgtcca tctgacttca caaagattgc tacctgttct gatgacaata cactaaaaat ctggcgcttg aatagaggct tagaggagaa accaggaggt gataaacttt ccacggtggg ttgggcctct cagaagaaaa aagagtcaag acctggccta gtaacagtaa cgagtagcca gagtactcct gccaaagccc ccagggtaaa gtgcaatcca tccaattctt ccccgtcatc cgcagcttgt gccccaagct gtgctggaga cctccctctt ccttcaaata ctcctacgtt ctctattaaa acctctcctg ccaaggcccg gtctcccatc aacagaagag gctctgtctc ctccgtctct cccaagccac cttcatcttt caagatgtcg attagaaact gggtgacccg aacaccttcc tcatcaccac ccatcactcc acctgcttcg gagaccaaga tcatgtctcc gagaaaagcc cttattcctg tgagccagaa gtcatcccaa gcagaggctt gctctgagtc tagaaataga gtaaagagga ggctagactc aagctgtctg gagagtgtga aacaaaagtg tgtgaagagt tgtaactgtg tgactgagct tgatggccaa gttgaaaatc ttcatttgga tctgtgctgc cttgctggta accaggaaga ccttagtaag gactctctag gtcctaccaa atcaagcaaa attgaaggag ctggtaccag tatctcagag cctccgtctc ctatcagtcc gtatgcttca gaaagctgtg gaacgctacc tcttcctttg agaccttgtg gagaagggtc tgaaatggta ggcaaagaga atagttcccc agagaataaa aactggttgt tggccatggc agccaaacgg aaggctgaga atccatctcc acgaagtccg tcatcccaga cacccaattc caggagacag agcggaaaga cattgccaag cccggtcacc atcacgccca gctccatgag gaaaatctgc acatacttcc atagaaagtc ccaggaggac ttctgtggtc ctgaacactc aacagaatta tag

Molecular Weight

23,682 Da

OMIM

610617

Vector

pENTR223.1

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of DTL cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for DTL. It may not necessarily be applicable to this product.

NCBI GI #

23271027

NCBI GeneID

51514

NCBI Accession #

BC033297

UniProt Secondary Accession #

Q5VT77; Q96SN0; Q9NW03; Q9NW34; Q9NWM5; A8K8H8; D3DT98

UniProt Related Accession #

Q9NZJ0

NCBI Official Full Name

Homo sapiens denticleless homolog (Drosophila), mRNA

NCBI Official Synonym Full Names

denticleless E3 ubiquitin protein ligase homolog

NCBI Official Symbol

DTL

NCBI Official Synonym Symbols

CDT2; RAMP; DCAF2; L2DTL

UniProt Protein Name

Denticleless protein homolog

UniProt Synonym Protein Names

DDB1- and CUL4-associated factor 2; Lethal(2) denticleless protein homolog; Retinoic acid-regulated nuclear matrix-associated protein

Protein Family

Denticleless protein

UniProt Gene Name

DTL

UniProt Synonym Gene Names

CDT2; CDW1; DCAF2; L2DTL; RAMP

UniProt Entry Name

DTL_HUMAN

NCBI Protein Information

denticleless protein homolog

UniProt Comments for DTL

RAMP: Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis. Belongs to the WD repeat cdt2 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin ligase; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: centrosome; cytoplasm; intracellular membrane-bound organelle; nucleolus; nucleoplasm; nucleus

Molecular Function: protein binding; ubiquitin-protein ligase activity

Biological Process: bypass DNA synthesis; DNA damage response, detection of DNA damage; G2/M transition DNA damage checkpoint; protein monoubiquitination; protein polyubiquitination; regulation of cell cycle; response to DNA damage stimulus; response to UV; ubiquitin-dependent protein catabolic process

Research Articles on DTL

1. CDT2 mediated XPG elimination from DNA damage sites clears the chromatin space needed for repair.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with DTL cdna clone

Disease Name	Pubmed Publications
Neoplasms Antibodies	>18 publications with DTL and Neoplasms
Disease Models, Animal Antibodies	>6 publications with DTL and Disease Models, Animal
Hypertension Antibodies	>4 publications with DTL and Hypertension
Adenocarcinoma Antibodies	>4 publications with DTL and Adenocarcinoma
Liver Diseases Antibodies	>2 publications with DTL and Liver Diseases
Inflammation Antibodies	>2 publications with DTL and Inflammation
Kidney Diseases Antibodies	>2 publications with DTL and Kidney Diseases
Neoplasms, Experimental Antibodies	>2 publications with DTL and Neoplasms, Experimental
Congenital Abnormalities Antibodies	>2 publications with DTL and Congenital Abnormalities
Liver Neoplasms Antibodies	>2 publications with DTL and Liver Neoplasms

Organs/Tissues associated with DTL cdna clone

Organ/Tissue Name	Pubmed Publications
Eye Antibodies	>52 publications with DTL and Eye
Kidney Antibodies	>32 publications with DTL and Kidney
Blood Antibodies	>20 publications with DTL and Blood
Vascular Antibodies	>14 publications with DTL and Vascular
Nerve Antibodies	>10 publications with DTL and Nerve
Skin Antibodies	>9 publications with DTL and Skin
Heart Antibodies	>6 publications with DTL and Heart
Bone Antibodies	>4 publications with DTL and Bone
Brain Antibodies	>4 publications with DTL and Brain
Lung Antibodies	>3 publications with DTL and Lung