Human EDEM2 cDNA Clone Expression Plasmid – Cat# MBS1273993

EDEM2 cDNA Clone – Er Degradation Enhancer, Mannosidase Alpha-Like 2 (Human)

Name: EDEM2 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1273993
Price: 400 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1273993

MBS1273993 is a cDNA clone targeting EDEM2. More details

$400 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

EDEM2, cDNA Clone

Full Product Name

EDEM2 cDNA Clone

Product Gene Name

EDEM2 cdna clone

Sequence

atgcctttcc ggctgctcat cccgctcggc ctcctgtgcg cgctgctgcc tcagcaccat ggtgcgccag gtcccgacgg ctccgcgcca gatcccgccc actacaggga gcgagtcaag gccatgttct accacgccta cgacagctac ctggagaatg cctttccctt cgatgagctg cgacctctca cctgtgacgg gcacgacacc tggggcagtt tttctctgac tctaattgat gcactggaca ccttgctgat tttggggaat gtctcagaat tccaaagagt ggttgaagtg ctccaggaca gcgtggactt tgatattgat gtgaacgcct ctgtgtttga aacaaacatt cgagtggtag gaggactcct gtctgctcat ctgctctcca agaaggctgg ggtggaagta gaggctggat ggccctgttc cgggcctctc ctgagaatgg ctgaggaggc ggcccgaaaa ctcctcccag cctttcagac ccccactggc atgccatatg gaacagtgaa cttacttcat ggcgtgaacc caggagagac ccctgtcacc tgtacggcag ggattgggac cttcattgtt gaatttgcca ccctgagcag cctcactggt gacccggtgt tcgaagatgt ggccagagtg gctttgatgc gcctctggga gagccggtca gatatcgggc tggtcggcaa ccacattgat gtgctcactg gcaagtgggt ggcccaggac gcaggcatcg gggctggcgt ggactcctac tttgagtact tggtgaaagg agccatcctg cttcaggata agaagctcat ggccatgttc ctagagtata acaaagccat ccggaactac acccgcttcg atgactggta cctgtgggtt cagatgtaca aggggactgt gtccatgcca gtcttccagt ccttggaggc ctactggcct ggtcttcaga gcctcattgg agacattgac aatgccatga ggaccttcct caactactac actgtatgga agcagtttgg ggggctcccg gaattctaca acattcctca gggatacaca gtggagaagc gagagggcta cccacttcgg ccagaactta ttgaaagcgc aatgtacctc taccgtgcca cgggggatcc caccctccta gaactcggaa gagatgctgt ggaatccatt gaaaaaatca gcaaggtgga gtgcggattt gcaacaatca aagatctgcg agaccacaag ctggacaacc gcatggagtc gttcttcctg gccgagactg tgaaatacct ctacctcctg tttgacccaa ccaacttcat ccacaacaat gggtccacct tcgacacggt gatcaccccc tatggggagt gcatcctggg ggctgggggg tacatcttca acacagaagc tcaccccatc gaccctgccg ccctgcactg ctgccagagg ctgaaggaag agcagtggga ggtggaggac ttgatgaggg aattctactc tctcaaacgg agcaggtcga aatttcagaa aaacactgtt agttcggggc catgggaacc tccagcaagg ccaggaacac tcttctcacc agaaaaccat gaccaggcaa gggagaggaa gcctgccaaa cagaaggtcc cacttctcag ctgccccagt cagcccttca cctccaagtt ggcattactg ggacaggttt tcctagactc ctcataa

Molecular Weight

60,319 Da

OMIM

610302

Vector

pENTR223.1 or pUC

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of EDEM2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for EDEM2. It may not necessarily be applicable to this product.

NCBI GI #

33990680

NCBI GeneID

55741

NCBI Accession #

BC001371

UniProt Secondary Accession #

Q6GU33; Q6IA89; Q6UWZ4; Q9H4U0; Q9H886; Q9NTL9; Q9NVE6; B4DTG9

UniProt Related Accession #

Q9BV94

NCBI Official Full Name

Homo sapiens ER degradation enhancer, mannosidase alpha-like 2, mRNA

NCBI Official Synonym Full Names

ER degradation enhancing alpha-mannosidase like protein 2

NCBI Official Symbol

EDEM2

NCBI Official Synonym Symbols

C20orf31; C20orf49; bA4204.1

UniProt Protein Name

ER degradation-enhancing alpha-mannosidase-like protein 2

Protein Family

ER degradation-enhancing alpha-mannosidase-like protein

UniProt Gene Name

EDEM2

UniProt Synonym Gene Names

C20orf31; C20orf49

UniProt Entry Name

EDEM2_HUMAN

NCBI Protein Information

ER degradation-enhancing alpha-mannosidase-like protein 2

NCBI Summary for EDEM2

In the endoplasmic reticulum (ER), misfolded proteins are retrotranslocated to the cytosol and degraded by the proteasome in a process known as ER-associated degradation (ERAD). EDEM2 belongs to a family of proteins involved in ERAD of glycoproteins (Mast et al., 2005 [PubMed 15537790]).[supplied by OMIM, Mar 2008]

UniProt Comments for EDEM2

EDEM2: Involved in endoplasmic reticulum-associated degradation (ERAD) that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. It lacks mannosidase activity. Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. Belongs to the glycosyl hydrolase 47 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 20q11.22

Cellular Component: endoplasmic reticulum

Molecular Function: alpha-mannosidase activity; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity

Biological Process: ER-associated protein catabolic process; N-glycan processing; unfolded protein response

Research Articles on EDEM2

1. EDEM2 and OS-9 are required for ER-associated degradation of non-glycosylated sonic hedgehog

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with EDEM2 cdna clone

Products by Pathway	Pathway Diagram
Asparagine N-linked Glycosylation Pathway antibodies	Asparagine N-linked Glycosylation Pathway Diagram
Calnexin/calreticulin Cycle Pathway antibodies	Calnexin/calreticulin Cycle Pathway Diagram
ER Quality Control Compartment (ERQC) Pathway antibodies	ER Quality Control Compartment (ERQC) Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
N-glycan Trimming In The ER And Calnexin/Calreticulin Cycle Pathway antibodies	N-glycan Trimming In The ER And Calnexin/Calreticulin Cycle Pathway Diagram
Post-translational Protein Modification Pathway antibodies	Post-translational Protein Modification Pathway Diagram
Protein Processing In Endoplasmic Reticulum Pathway antibodies	Protein Processing In Endoplasmic Reticulum Pathway Diagram
Protein Processing In Endoplasmic Reticulum Pathway antibodies	Protein Processing In Endoplasmic Reticulum Pathway Diagram

Diseases associated with EDEM2 cdna clone

Disease Name	Pubmed Publications
Fibrosis Antibodies	>1 publications with EDEM2 and Fibrosis
Death Antibodies	>1 publications with EDEM2 and Death
Inflammation Antibodies	>1 publications with EDEM2 and Inflammation

Organs/Tissues associated with EDEM2 cdna clone

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>2 publications with EDEM2 and Blood
Brain Antibodies	>2 publications with EDEM2 and Brain
Vascular Antibodies	>1 publications with EDEM2 and Vascular
Lung Antibodies	>1 publications with EDEM2 and Lung