Human EIF2AK4 cDNA Clone Expression Plasmid – Cat# MBS1268095

EIF2AK4 cDNA Clone – Eukaryotic Translation Initiation Factor 2 Alpha Kinase 4 (Human)

Name: EIF2AK4 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1268095
Price: 520 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1268095

MBS1268095 is a cDNA clone targeting EIF2AK4. More details

$520 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

EIF2AK4, cDNA Clone

Full Product Name

EIF2AK4 cDNA Clone

Product Gene Name

EIF2AK4 cdna clone

Sequence

atgattcacc gggatttgaa gcctgtcaac atttttttgg attctgatga ccatgtgaaa ataggtgatt ttggtttggc gacagaccat ctagcctttt ctgctgacag caaacaagac gatcagacag gagacttgat taagtcagac ccttcaggtc acttaactgg gatggttggc actgctctct atgtaagccc agaggtccaa ggaagcacca aatctgcata caaccagaaa gtggatctct tcagcctggg aattatcttc tttgagatgt cctatcaccc catggtcacg gcttcagaaa ggatctttgt tctcaaccaa ctcagagatc ccacttcgcc taagtttcca gaagactttg acgatggaga gcatgcaaag cagaaatcag tcatctcctg gctgttgaac cacgatccag caaaacggcc cacagccaca gaactgctca agagtgagct gctgccccca ccccagatgg aggagtcaga gctgcatgaa gtgctgcacc acacgctgac caacgtggat gggaaggcct accgcaccat gatggcccag atcttctcgc agcgcatctc ccctgccatc gattacacct atgacagcga catactgaag ggcaacttct caatccgtac agccaagatg cagcagcatg tgtgtgaaac catcatccgc atctttaaaa gacatggagc tgttcagttg tgtactccac tactgcttcc ccgaaacaga caaatatatg agcacaacga agctgcccta ttcatggacc acagcgggat gctggtgatg cttccttttg acctgcggat cccttttgca agatatgtgg caagaaataa tatattgaat ttaaaacgat actgcataga acgtgtgttc aggccgcgca agttagatcg atttcatccc aaagaacttc tggagtgtgc atttgatatt gtcacttcta ccaccaacag ctttctgccc actgctgaaa ttatctacac tatctatgaa atcatccaag agtttccagc acttcaggaa agaaattaca gtatttattt gaaccatacc atgttattga aagcaatact cttacactgt gggatcccag aagataaact cagtcaagtc tacattattc tgtatgatgc tgtgacagag aagctgacga ggagagaagt ggaagctaaa ttttgtaatc tgtctttgtc ttctaatagt ctgtgtcgac tctacaagtt tattgaacag aagggagatt tgcaagatct tatgccaaca ataaattcat taataaaaca gaaaacaggt attgcacagt tggtgaagta tggcttaaaa gacctagagg aggttgttgg actgttgaag aaactctgca tcaagttaca ggtcttgatc aatttgggct tggtttacaa ggtgcagcag cacaatggaa tcatcttcca gtttgtggct ttcatcaaac gaaggcaaag ggctgtacct gaaatcctcg cagctggagg cagatatgac ctgctgattc cccagtttag agggccacaa gctctggggc cagttcccac tgccattggg gtcagcatag ctatagacaa gatatctgct gctgtcctca acatggagga atctgttaca ataagctctt gtgacctcct ggttgtaagt gttggccaga tgtctatgtc cagggccatc aacctaaccc agaaactctg gacagcaggc atcacagcag aaatcatgta cgactggtca cagtcccaag aggaattaca agagtactgc agacatcatg aaatcaccta tgtggccctt gtctcggata aagaaggaag ccatgtcaag gttaagtctt tcgagaagga aaggcagaca gagaagcgtg tgctggagac tgaacttgtg gaccatgtac tgcagaaact gaggactaaa gtcactgatg aaaggaatgg cagagaagct tccgataatc ttgcagtgca aaatctgaag gggtcatttt ctaatgcttc aggtttgttt gaaatccatg gagcaacagt ggttcccatt gtgagtgtgc tagccccgga gaagctgtca gccagcacta ggaggcgcta tgaaactcag gtacaaactc gacttcagac ctcccttgcc aacttacatc agaaaagcag tgaaattgaa attctggctg tggatctacc caaagaaaca atattacagt ttttatcatt agagtgggat gctgatgaac aggcatttaa cacaactgtg aagcagctgc tgtcacgcct gccaaagcaa agatacctca aattagtctg tgatgaaatt tataacatca aagtagaaaa aaaggtgtct gtgctatttc tgtacagcta tagagatgac tactacagaa tcttatttta a

Molecular Weight

69,797 Da

OMIM

234810

Vector

pENTR223.1 or pUC

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of EIF2AK4 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for EIF2AK4. It may not necessarily be applicable to this product.

NCBI GI #

39645017

NCBI GeneID

440275

NCBI Accession #

BC009350

UniProt Secondary Accession #

Q69YL7; Q6DC97; Q96GN6; Q9H5K1; Q9NSQ3; Q9NSZ5; Q9UJ56; C9JEC4

UniProt Related Accession #

Q9P2K8

NCBI Official Full Name

Homo sapiens eukaryotic translation initiation factor 2 alpha kinase 4, mRNA

NCBI Official Synonym Full Names

eukaryotic translation initiation factor 2 alpha kinase 4

NCBI Official Symbol

EIF2AK4

NCBI Official Synonym Symbols

GCN2; PVOD2

UniProt Protein Name

eIF-2-alpha kinase GCN2

UniProt Synonym Protein Names

Eukaryotic translation initiation factor 2-alpha kinase 4

Protein Family

eIF-2-alpha kinase

UniProt Gene Name

EIF2AK4

UniProt Entry Name

E2AK4_HUMAN

NCBI Protein Information

eIF-2-alpha kinase GCN2

NCBI Summary for EIF2AK4

This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2. [provided by RefSeq, Mar 2014]

UniProt Comments for EIF2AK4

GCN2: a kinase of the PEK family. Phosphorylates and inhibits eukaryotic initiation factor (eIF)-2 alpha, providing an important protective mechanism during various cellular stress conditions including endoplasmic reticulum (ER) stress.

Protein type: Translation; Kinase, protein; EC 2.7.11.1; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Other group; PEK family; GCN2 subfamily

Chromosomal Location of Human Ortholog: 15q15.1

Cellular Component: polysome

Molecular Function: eukaryotic translation initiation factor 2alpha kinase activity; protein serine/threonine kinase activity; tRNA binding

Biological Process: cellular response to amino acid starvation; inhibition of CREB transcription factor; learning; long-term memory; negative regulation of neuron differentiation; negative regulation of translation initiation in response to stress; negative regulation of translational initiation; positive regulation of adaptive immune response; positive regulation of defense response to virus by host; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of translational initiation; T cell activation during immune response; viral protein biosynthetic process

Disease: Pulmonary Venoocclusive Disease 2, Autosomal Recessive

Research Articles on EIF2AK4

1. Targeting ALDH18A1 activated the serine/threonine protein kinase GCN2 (general control nonderepressible 2) to inhibit protein synthesis in melanoma.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with EIF2AK4 cdna clone

Products by Pathway	Pathway Diagram
Epstein-Barr Virus Infection Pathway antibodies	Epstein-Barr Virus Infection Pathway Diagram
Epstein-Barr Virus Infection Pathway antibodies	Epstein-Barr Virus Infection Pathway Diagram
Hepatitis C Pathway antibodies	Hepatitis C Pathway Diagram
Hepatitis C Pathway antibodies	Hepatitis C Pathway Diagram
Herpes Simplex Infection Pathway antibodies	Herpes Simplex Infection Pathway Diagram
Herpes Simplex Infection Pathway antibodies	Herpes Simplex Infection Pathway Diagram
Influenza A Pathway antibodies	Influenza A Pathway Diagram
Influenza A Pathway antibodies	Influenza A Pathway Diagram
Measles Pathway antibodies	Measles Pathway Diagram
Measles Pathway antibodies	Measles Pathway Diagram

Diseases associated with EIF2AK4 cdna clone

Disease Name	Pubmed Publications
Neoplasms Antibodies	>6 publications with EIF2AK4 and Neoplasms
Immune System Diseases Antibodies	>6 publications with EIF2AK4 and Immune System Diseases
Inflammation Antibodies	>4 publications with EIF2AK4 and Inflammation
Lymphoma Antibodies	>3 publications with EIF2AK4 and Lymphoma
Disease Models, Animal Antibodies	>3 publications with EIF2AK4 and Disease Models, Animal
Drug Toxicity Antibodies	>3 publications with EIF2AK4 and Drug Toxicity
Weight Loss Antibodies	>2 publications with EIF2AK4 and Weight Loss
Drug-Induced Liver Injury Antibodies	>2 publications with EIF2AK4 and Drug-Induced Liver Injury
Necrosis Antibodies	>2 publications with EIF2AK4 and Necrosis
Liver Neoplasms Antibodies	>2 publications with EIF2AK4 and Liver Neoplasms

Organs/Tissues associated with EIF2AK4 cdna clone

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>21 publications with EIF2AK4 and Blood
Liver Antibodies	>17 publications with EIF2AK4 and Liver
Brain Antibodies	>9 publications with EIF2AK4 and Brain
Muscle Antibodies	>5 publications with EIF2AK4 and Muscle
Kidney Antibodies	>5 publications with EIF2AK4 and Kidney
Bone Antibodies	>3 publications with EIF2AK4 and Bone
Spleen Antibodies	>3 publications with EIF2AK4 and Spleen
Pancreas Antibodies	>3 publications with EIF2AK4 and Pancreas
Connective Tissue Antibodies	>2 publications with EIF2AK4 and Connective Tissue
Intestine Antibodies	>2 publications with EIF2AK4 and Intestine