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EIF2B2 cDNA Clone – Eukaryotic Translation Initiation Factor 2b, Subunit 2 Beta, 39kDa (Human)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1278628

MBS1278628 is a cDNA clone targeting EIF2B2. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
EIF2B2, cDNA Clone
Full Product Name
EIF2B2 cDNA Clone
Product Gene Name
EIF2B2 cdna clone
Sequence
atgccgggat ccgcagcgaa gggctcggag ttgtcagaga ggatcgagag cttcgtggag accctgaagc ggggtggtgg gccgcgcagc tccgaggaaa tggctcggga gaccctaggg ttgctgcgcc agatcatcac ggaccaccgc tggagcaacg cgggggagct gatggagctg atccgcagag agggcaggag gatgacggcc gctcagccct ccgagaccac cgtgggcaac atggtgcgga gagtgctcaa gattatccgg gaggagtatg gcagactcca tggacgcagc gacgagagtg atcagcagga gtccctgcac aaactgttga catccggagg cctaaacgag gatttcagct tccattatgc ccaactccag tccaacatca ttgaggcgat taatgagctg ctagtggagc tggaagggac aatggagaac attgcagccc aggctctgga gcacattcac tccaatgagg tgatcatgac cattggcttc tcccgaacag tagaggcctt cctcaaagag gctgcccgaa agaggaaatt ccatgtcatt gtagcagagt gtgctccttt ctgccagggt catgaaatgg ctgtgaattt gtccaaagca ggtattgaga caactgtcat gactgatgct gccatttttg ccgttatgtc aagagtcaac aaggtgatca ttggcacgaa gaccatcctg gccaatgggg ccctgagagc tgtgacagga actcacactc tggcactggc agcaaaacac cattccaccc cactcatcgt ctgtgcacct atgttcaaac tttctccaca gttccccaat gaagaagact catttcataa gtttgtggct cctgaagaag tcctgccatt cacagaaggg gacattctgg agaaggtcag cgtgcattgc cctgtgtttg actacgttcc cccagagctc attaccctct ttatctccaa cattggtggg aatgcacctt cctacatcta ccgcctgatg agtgaactct accatcctga tgatcatgtt ttatga
Molecular Weight
38,990 Da
OMIM
603896
Vector
pENTR223.1 or pUC
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of EIF2B2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for EIF2B2. It may not necessarily be applicable to this product.

NCBI GI #
40225634
NCBI GeneID
8892
NCBI Accession #
BC011750
UniProt Secondary Accession #
O43201
UniProt Related Accession #
P49770
NCBI Official Full Name
Homo sapiens eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa, mRNA
NCBI Official Synonym Full Names
eukaryotic translation initiation factor 2B subunit beta
NCBI Official Symbol
EIF2B2
NCBI Official Synonym Symbols
EIF2B; EIF-2Bbeta
UniProt Protein Name
Translation initiation factor eIF-2B subunit beta
UniProt Synonym Protein Names
S20I15; S20III15; eIF-2B GDP-GTP exchange factor subunit beta
Protein Family
Translation initiation factor
UniProt Gene Name
EIF2B2
UniProt Synonym Gene Names
EIF2BB
UniProt Entry Name
EI2BB_HUMAN
NCBI Protein Information
translation initiation factor eIF-2B subunit beta

NCBI Summary for EIF2B2

This gene encodes the beta subunit of eukaryotic initiation factor-2B (EIF2B). EIF2B is involved in protein synthesis and exchanges GDP and GTP for its activation and deactivation. [provided by RefSeq, Aug 2011]

UniProt Comments for EIF2B2

eIF2B-beta: eukaryotic translation initiation factor 2B, subunit 5. A translational regulatory protein that functions in the early steps of protein synthesis by catalyzing the exchange of eukaryotic initiation factor 2-bound GDP for GTP. Mutation in EIF2B5 causes childhood ataxia with central nervous system hypomyelination/ vanishing white matter leukodystrophy.

Protein type: Translation; Cell development/differentiation; RNA-binding; GEFs; GEFs, misc.

Chromosomal Location of Human Ortholog: 14q24.3

Cellular Component: cytoplasm; cytosol; eukaryotic translation initiation factor 2B complex

Molecular Function: ATP binding; GTP binding; guanyl-nucleotide exchange factor activity; protein binding; S-methyl-5-thioribose-1-phosphate isomerase activity; translation initiation factor activity

Biological Process: cellular response to stimulus; central nervous system development; methionine salvage; myelination; oligodendrocyte development; ovarian follicle development; regulation of translational initiation; response to glucose stimulus; response to heat; response to peptide hormone stimulus; translational initiation

Disease: Leukoencephalopathy With Vanishing White Matter
Show more

Research Articles on EIF2B2

1. An Italian patient is described with a c.638A>G mutation in exon 5 of EIF2B2 gene with very slow progressive vanishing white matter disease.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with EIF2B2 cdna clone

 Products by Pathway  Pathway Diagram
 Cap-dependent Translation Initiation Pathway antibodies  Cap-dependent Translation Initiation Pathway Diagram
 Eukaryotic Translation Initiation Pathway antibodies  Eukaryotic Translation Initiation Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 RNA Transport Pathway antibodies  RNA Transport Pathway Diagram
 RNA Transport Pathway antibodies  RNA Transport Pathway Diagram
 Recycling Of EIF2:GDP Pathway antibodies  Recycling Of EIF2:GDP Pathway Diagram
 Translation Pathway antibodies  Translation Pathway Diagram
 Translation Factors Pathway antibodies  Translation Factors Pathway Diagram

Diseases associated with EIF2B2 cdna clone

 Disease Name  Pubmed Publications
 LEUKOENCEPHALOPATHY WITH VANISHING WHITE MATTER Antibodies  >11 publications with EIF2B2 and LEUKOENCEPHALOPATHY WITH VANISHING WHITE MATTER
 Brain Diseases Antibodies  >10 publications with EIF2B2 and Brain Diseases
 Cardiovascular Diseases Antibodies  >1 publications with EIF2B2 and Cardiovascular Diseases
 Arteriosclerosis Antibodies  >1 publications with EIF2B2 and Arteriosclerosis
 Cognition Disorders Antibodies  >1 publications with EIF2B2 and Cognition Disorders
 Hepatomegaly Antibodies  >1 publications with EIF2B2 and Hepatomegaly
 Inflammation Antibodies  >1 publications with EIF2B2 and Inflammation
 Necrosis Antibodies  >1 publications with EIF2B2 and Necrosis

Organs/Tissues associated with EIF2B2 cdna clone

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >11 publications with EIF2B2 and Brain
 Vascular Antibodies  >1 publications with EIF2B2 and Vascular
 Muscle Antibodies  >1 publications with EIF2B2 and Muscle
 Liver Antibodies  >1 publications with EIF2B2 and Liver
 Mammary Gland Antibodies  >1 publications with EIF2B2 and Mammary Gland
 Mouth Antibodies  >1 publications with EIF2B2 and Mouth
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