EIF4E cDNA Clone – Eukaryotic Translation Initiation Factor 4e (Human)

The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

EIF4E: a protein of the eukaryotic initiation factor 4E family. Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Phosphorylation increases the ability of the protein to bind to mRNA caps and to form the EIF4F complex.

Protein type: Translation; Translation initiation

Chromosomal Location of Human Ortholog: 4q23

Cellular Component: cytoplasm; cytosol; eukaryotic translation initiation factor 4F complex; mRNA cap complex; perinuclear region of cytoplasm; stress granule

Molecular Function: enzyme binding; eukaryotic initiation factor 4G binding; protein binding; RNA cap binding; translation initiation factor activity

Biological Process: G1/S transition of mitotic cell cycle; mRNA export from nucleus; negative regulation of autophagy; poly(A) tail shortening; positive regulation of mitotic cell cycle; regulation of translation; RNA export from nucleus; translational initiation

Disease: Autism, Susceptibility To, 19