Human EIF4G2 cDNA Clone Expression Plasmid – Cat# MBS1272984

EIF4G2 cDNA Clone – Eukaryotic Translation Initiation Factor 4 Gamma, 2 (Human)

Name: EIF4G2 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1272984
Price: 800 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1272984

MBS1272984 is a cDNA clone targeting EIF4G2. More details

$800 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

EIF4G2, cDNA Clone

Full Product Name

EIF4G2 cDNA Clone

Product Gene Name

EIF4G2 cdna clone

Sequence

ATGTTGGGAA ACATCAAATT CATTGGAGAG CTTGGCAAGC TTGATCTTAT TCACGAATCT ATCCTTCATA AGTGCATCAA AACACTTTTG GAAAAGAAGA AGAGAGTCCA ACTCAAAGAT ATGGGAGAGG ATTTGGAGTG CCTCTGTCAG ATAATGAGGA CAGTGGGACC TAGATTAGAC CATGAACGAG CCAAGTCCTT AATGGATCAG TACTTTGCCC GAATGTGCTC CTTGATGTTA AGTAAGGAAT TGCCAGCAAG GATTCGTTTC CTGCTGCAGG ATACCGTAGA GTTGCGAGAA CACCATTGGG TTCCTCGCAA GGCTTTTCTT GACAATGGAC CAAAGACGAT CAATCAAATT CGTCAAGATG CAGTAAAAGA TCTAGGGGTG TTTATTCCTG CTCCTATGGC TCAAGGGATG AGAAGTGACT TCTTTCTGGA GGGACCGTTC ATGCCACCCA GGATGAAAAT GGATAGGGAC CCACTTGGAG GACTTGCTGA TATGTTTGGA CAAATGCCAG GTAGCGGAAT TGGTACTGGT CCAGGAGTTA TCCAGGATAG ATTTTCACCC ACCATGGGAC GTCATCGTTC AAATCAACTC TTCAATGGCC ATGGGGGACA CATCATGCCT CCCACACAAT CGCAGTTTGG AGAGATGGGA GGCAAGTTTA TGAAAAGCCA GGGGCTAAGC CAGCTCTACC ATAACCAGAG TCAGGGACTC TTATCCCAGC TGCAAGGACA GTCGAAGGAT ATGCCACCTC GGTTTTCTAA GAAAGGACAG CTTAATGCAG ATGAGATTAG CCTGAGGCCT GCTCAGTCGT TCCTAATGAA TAAAAATCAA GTGCCAAAGC TTCAGCCCCA GATAACTATG ATTCCTCCTA GTGCACAACC ACCACGCACT CAAACACCAC CTCTGGGACA GACACCTCAG CTTGGTCTCA AAACTAATCC ACCACTTATC CAGGAAAAGC CTGCCAAGAC CAGCAAAAAG CCACCACCGT CAAAGGAAGA ACTCCTTAAA CTAACTGAAA CTGTTGTGAC TGAATATCTA AATAGTGGAA ATGCAAATGA GGCTGTCAAT GGTGTAAGAG AAATGAGGGC TCCTAAACAC TTTCTTCCTG AGATGTTAAG CAAAGTAATC ATCCTGTCAC TAGATAGAAG CGATGAAGAT AAAGAAAAAG CAAGTTCTTT GATCAGTTTA CTCAAACAGG AAGGGATAGC CACAAGTGAC AACTTCATGC AGGCTTTCCT GAATGTATTG GACCAGTGTC CCAAACTGGA GGTTGACATC CCTTTGGTGA AATCCTATTT AGCACAGTTT GCAGCTCGTG CCATCATTTC AGAGCTGGTG AGCATTTCAG AACTAGCTCA ACCACTAGAA AGTGGCACCC ATTTTCCTCT CTTTCTACTT TGTCTTCAGC AGTTAGCTAA ATTACAAGAT CGAGAATGGT TAACAGAACT TTTTCAACAA AGCAAGGTCA ATATGCAGAA AATGCTCCCA GAAATTGATC AGAATAAGGA CCGCATGTTG GAGATTTTGG AAGGAAAGGG ACTGAGTTTC TTATTCCCAC TCCTCAAATT GGAGAAGGAA CTGTTGAAGC AAATAAAGTT GGATCCATCC CCTCAAACCA TATATAAATG GATTAAAGAT AACATCTCTC CCAAACTTCA TGTAGATAAA GGATTTGTGA ACATCTTAAT GACTAGCTTC TTACAGTACA TTTCTAGTGA AGTAAACCCC CCCAGCGATG AAACAGATTC ATCCTCTGCT CCTTCCAAAG AACAGTTAGA GCAGGAAAAA CAACTACTAC TATCTTTCAA GCCAGTAATG CAGAAATTTC TTCATGATCA CGTTGATCTA CAAGTCAGTG CCCTGTATGC TCTCCAGGTG CACTGCTATA ACAGCAACTT CCCAAAAGGC ATGTTACTTC GCTTTTTTGT GCACTTCTAT GACATGGAAA TTATTGAAGA AGAAGCTTTC TTGGCTTGGA AAGAAGATAT AACCCAAGAG TTTCCGGGAA AAGGCAAGGC TTTGTTCCAG GTGAATCAGT GGCTAACCTG GTTAGAAACT GCTGAAGAAG AAGAATCAGA GGAAGAAGCT GACTAA

Molecular Weight

98,150 Da

OMIM

602325

Vector

Please Inquire

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of EIF4G2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for EIF4G2. It may not necessarily be applicable to this product.

NCBI GI #

40850977

NCBI GeneID

1982

NCBI Accession #

BC065276

UniProt Secondary Accession #

O60877; P78404; Q0VH00; Q0VH01; Q2NKW9; Q49A79; Q53EU1; Q58EZ2; Q8NI71; Q96C16

UniProt Related Accession #

P78344

NCBI Official Full Name

Homo sapiens eukaryotic translation initiation factor 4 gamma, 2, mRNA

NCBI Official Synonym Full Names

eukaryotic translation initiation factor 4 gamma 2

NCBI Official Symbol

EIF4G2

NCBI Official Synonym Symbols

P97; AAG1; DAP5; NAT1

UniProt Protein Name

Eukaryotic translation initiation factor 4 gamma 2

UniProt Synonym Protein Names

Death-associated protein 5; DAP-5; p97

Protein Family

Eukaryotic translation initiation factor

UniProt Gene Name

EIF4G2

UniProt Synonym Gene Names

eIF-4-gamma 2; eIF-4G 2; eIF4G 2; DAP-5

UniProt Entry Name

IF4G2_HUMAN

NCBI Protein Information

eukaryotic translation initiation factor 4 gamma 2

NCBI Summary for EIF4G2

Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008]

UniProt Comments for EIF4G2

EIF4G2: a general repressor of translation by forming translationally inactive complexes. Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Interacts with the protein kinases Mnk1 and -2. Binds EIF4A and EIF3. Cleaved by some caspases and viral proteases.

Protein type: RNA-binding; Translation initiation; Translation

Chromosomal Location of Human Ortholog: 11p15

Cellular Component: cell-cell adherens junction; cytosol; eukaryotic translation initiation factor 4F complex; membrane

Molecular Function: protein binding; translation factor activity, nucleic acid binding; translation initiation factor activity

Biological Process: cell cycle arrest; cell death; regulation of translational initiation

Research Articles on EIF4G2

1. Knockdown of EIF4G2 recapitulated the effects of mir-139, whereas restoring EIF4G2 expression rescued the mir-139 phenotype. elevated miR-139-5p expression is associated with a favorable outcome in acute myeloid leukemia.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with EIF4G2 cdna clone

Products by Pathway	Pathway Diagram
Antiviral Mechanism By IFN-stimulated Genes Pathway antibodies	Antiviral Mechanism By IFN-stimulated Genes Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
Diurnally Regulated Genes With Circadian Orthologs Pathway antibodies	Diurnally Regulated Genes With Circadian Orthologs Pathway Diagram
ISG15 Antiviral Mechanism Pathway antibodies	ISG15 Antiviral Mechanism Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Interferon Signaling Pathway antibodies	Interferon Signaling Pathway Diagram
RNA Transport Pathway antibodies	RNA Transport Pathway Diagram
RNA Transport Pathway antibodies	RNA Transport Pathway Diagram
Viral Myocarditis Pathway antibodies	Viral Myocarditis Pathway Diagram
EIF4F Complex Pathway antibodies	EIF4F Complex Pathway Diagram

Diseases associated with EIF4G2 cdna clone

Disease Name	Pubmed Publications
Neoplasms Antibodies	>6 publications with EIF4G2 and Neoplasms
Carcinoma Antibodies	>2 publications with EIF4G2 and Carcinoma
Cell Transformation, Neoplastic Antibodies	>1 publications with EIF4G2 and Cell Transformation, Neoplastic
Liver Neoplasms Antibodies	>1 publications with EIF4G2 and Liver Neoplasms
Carcinoma, Hepatocellular Antibodies	>1 publications with EIF4G2 and Carcinoma, Hepatocellular
Inflammation Antibodies	>1 publications with EIF4G2 and Inflammation
Necrosis Antibodies	>1 publications with EIF4G2 and Necrosis

Organs/Tissues associated with EIF4G2 cdna clone

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>3 publications with EIF4G2 and Blood
Mouth Antibodies	>3 publications with EIF4G2 and Mouth
Muscle Antibodies	>2 publications with EIF4G2 and Muscle
Bladder Antibodies	>1 publications with EIF4G2 and Bladder
Connective Tissue Antibodies	>1 publications with EIF4G2 and Connective Tissue
Kidney Antibodies	>1 publications with EIF4G2 and Kidney
Liver Antibodies	>1 publications with EIF4G2 and Liver
Lung Antibodies	>1 publications with EIF4G2 and Lung
Ganglia Antibodies	>1 publications with EIF4G2 and Ganglia
Adipose Tissue Antibodies	>1 publications with EIF4G2 and Adipose Tissue