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ELMO1 cDNA Clone – Engulfment and Cell Motility 1 (Human)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1277063

MBS1277063 is a cDNA clone targeting ELMO1. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ELMO1, cDNA Clone
Full Product Name
ELMO1 cDNA Clone
Product Gene Name
ELMO1 cdna clone
Sequence
ATGCCGCCAC CCGCGGACAT CGTCAAGGTG GCCATAGAAT GGCCGGGCGC CTACCCCAAA CTCATGGAAA TTGATCAGAA AAAACCACTG TCTGCAATAA TAAAGGAAGT CTGTGATGGG TGGTCTCTTG CCAACCATGA ATATTTTGCA CTCCAGCATG CCGATAGTTC AAACTTCTAT ATCACAGAAA AGAACCGCAA TGAGATAAAA AATGGCACTA TCCTTCGATT AACCACATCT CCAGCTCAGA ACGCCCAGCA GCTCCATGAA CGAATCCAGT CCTCGAGTAT GGATGCCAAG CTGGAAGCCC TGAAGGACTT GGCCAGCCTC TCCCGGGATG TCACGTTTGC CCAGGAGTTT ATAAACCTGG ACGGTATCTC TCTCCTCACG CAGATGGTAG AGAGCGGCAC TGAGCGATAC CAGAAATTGC AGAAGATCAT GAAGCCTTGC TTTGGAGACA TGCTGTCCTT CACCCTGACG GCCTTCGTTG AGCTGATGGA CCATGGCATA GTGTCCTGGG ATACATTTTC GGTGGCGTTC ATTAAGAAGA TAGCAAGTTT TGTGAACAAG TCAGCCATAG ACATCTCGAT CCTGCAGCGG TCCTTGGCCA TTTTGGAGTC GATGGTGCTC AATAGCCATG ACCTCTACCA GAAAGTGGCG CAGGAGATCA CCATCGGCCA GCTCATTCCA CACCTGCAAG GGTCAGATCA AGAAATCCAA ACCTATACTA TTGCAGTGAT TAATGCGCTT TTCCTGAAGG CTCCTGATGA GAGGAGGCAG GAGATGGCGA ATATTTTGGC TCAGAAGCAA CTGCGTTCCA TCATTTTAAC ACATGTCATC CGAGCCCAGC GGGCCATCAA CAATGAGATG GCGCACCAGC TGTATGTTCT ACAAGTGCTC ACCTTTAACC TCCTGGAAGA CAGGATGATG ACCAAAATGG ACCCCCAGGA CCAGGCTCAG AGGGACATCA TATTTGAACT TCGAAGAATT GCTTTTGATG CTGAGTCTGA ACCTAACAAC AGCAGTGGCA GCATGGAGAA ACGCAAGTCC ATGTACACGC GAGATTATAA GAAGCTTGGG TTCATTAATC ATGTCAACCC TGCCATGGAC TTCACGCAGA CTCCACCTGG GATGTTGGCT CTGGACAACA TGCTGTACTT TGCCAAGCAC CACCAAGATG CCTACATCCG GATTGTGCTT GAGAACAGTA GTCGAGAAGA CAAGCATGAA TGTCCCTTTG GCCGCAGTAG TATAGAGCTG ACCAAGATGC TATGTGAGAT CTTGAAAGTG GGCGAGTTGC CTAGTGAGAC CTGCAACGAC TTCCACCCGA TGTTCTTCAC CCACGACAGA TCCTTTGAGG AGTTTTTCTG CATCTGTATC CAGCTCCTGA ACAAGACATG GAAGGAAATG AGGGCAACTT CTGAAGACTT CAACAAGGTA ATGCAGGTGG TGAAGGAGCA GGTTATGAGA GCACTTACAA CCAAGCCTAG CTCCCTGGAC CAGTTCAAGA GCAAACTGCA GAACCTGAGC TACACTGAGA TCCTGAAAAT CCGCCAGTCC GAGAGGATGA ACCAGGAAGA TTTCCAGTCC CGCCCGATTT TGGAACTAAA GGAGAAGATT CAGCCAGAAA TCTTAGAGCT GATCAAACAG CAACGCCTGA ACCGCCTTGT GGAAGGGACC TGCTTTAGGA AACTCAATGC CCGGCGGAGG CAAGACAAGT TTTGGTATTG TCGGCTTTCG CCAAATCACA AAGTCCTGCA TTACGGAGAC TTAGAAGAGA GTCCTCAGGG AGAAGTGCCC CACGATTCCT TGCAGGACAA ACTGCCGGTG GCAGATATCA AAGCCGTGGT GACGGGAAAG GACTGCCCTC ATATGAAAGA GAAAGGTGCC CTTAAACAAA ACAAGGAGGT GCTTGAACTC GCTTTCTCCA TCTTGTATGA CTCAAACTGC CAACTGAACT TCATCGCTCC TGACAAGCAT GAGTACTGTA TCTGGACGGA TGGACTGAAT GCGCTACTCG GGAAGGACAT GATGAGCGAC CTGACGCGGA ATGACCTGGA CACCCTGCTC AGCATGGAAA TCAAGCTCCG CCTCCTGGAC CTGGAAAACA TCCAGATCCC TGACGCACCT CCGCCGATTC CCAAGGAGCC CAGCAACTAT GACTTCGTCT ATGACTGTAA CTGA
Molecular Weight
49,915 Da
OMIM
606420
Vector
pENTR223.1
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of ELMO1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ELMO1. It may not necessarily be applicable to this product.

NCBI GI #
115527628
NCBI GeneID
9844
NCBI Accession #
BC114341
UniProt Secondary Accession #
Q29R79; Q6ZTJ0; Q96PB0; Q9H0I1; A4D1X6
UniProt Related Accession #
Q92556
NCBI Official Full Name
Homo sapiens engulfment and cell motility 1, mRNA
NCBI Official Synonym Full Names
engulfment and cell motility 1
NCBI Official Symbol
ELMO1
NCBI Official Synonym Symbols
CED12; CED-12; ELMO-1
UniProt Protein Name
Engulfment and cell motility protein 1
UniProt Synonym Protein Names
Protein ced-12 homolog
Protein Family
Engulfment and cell motility protein
UniProt Gene Name
ELMO1
UniProt Synonym Gene Names
KIAA0281
UniProt Entry Name
ELMO1_HUMAN
NCBI Protein Information
engulfment and cell motility protein 1

NCBI Summary for ELMO1

This gene encodes a member of the engulfment and cell motility protein family. These proteins interact with dedicator of cytokinesis proteins to promote phagocytosis and cell migration. Increased expression of this gene and dedicator of cytokinesis 1 may promote glioma cell invasion, and single nucleotide polymorphisms in this gene may be associated with diabetic nephropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
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UniProt Comments for ELMO1

ELMO1: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 7p14.1

Cellular Component: cytoplasm; cytosol; membrane; plasma membrane

Molecular Function: guanyl-nucleotide exchange factor activity; protein binding; SH3 domain binding

Biological Process: actin cytoskeleton organization and biogenesis; cell motility; phagocytosis, engulfment; Rac protein signal transduction; regulation of defense response to virus by virus; vascular endothelial growth factor receptor signaling pathway
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Research Articles on ELMO1

1. ELMO1 is expressed in rheumatoid arthritis synovium, promotes cell migration and invasion, and regulates Rac1 activity, thereby mediating rheumatoid arthritis pathogenicity.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with ELMO1 cdna clone

 Products by Pathway  Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway antibodies  Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway Diagram
 HIV Infection Pathway antibodies  HIV Infection Pathway Diagram
 Host Interactions Of HIV Factors Pathway antibodies  Host Interactions Of HIV Factors Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram

Diseases associated with ELMO1 cdna clone

 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >15 publications with ELMO1 and Kidney Diseases
 Neoplasms Antibodies  >6 publications with ELMO1 and Neoplasms
 Proteinuria Antibodies  >5 publications with ELMO1 and Proteinuria
 Immune System Diseases Antibodies  >5 publications with ELMO1 and Immune System Diseases
 Renal Insufficiency Antibodies  >4 publications with ELMO1 and Renal Insufficiency
 Brain Diseases Antibodies  >2 publications with ELMO1 and Brain Diseases
 Vascular Diseases Antibodies  >2 publications with ELMO1 and Vascular Diseases
 Nervous System Diseases Antibodies  >2 publications with ELMO1 and Nervous System Diseases
 Neoplasms, Experimental Antibodies  >1 publications with ELMO1 and Neoplasms, Experimental
 Ovarian Neoplasms Antibodies  >1 publications with ELMO1 and Ovarian Neoplasms

Organs/Tissues associated with ELMO1 cdna clone

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >11 publications with ELMO1 and Kidney
 Brain Antibodies  >10 publications with ELMO1 and Brain
 Blood Antibodies  >8 publications with ELMO1 and Blood
 Testis Antibodies  >3 publications with ELMO1 and Testis
 Lung Antibodies  >2 publications with ELMO1 and Lung
 Lymph Antibodies  >1 publications with ELMO1 and Lymph
 Lymph Node Antibodies  >1 publications with ELMO1 and Lymph Node
 Muscle Antibodies  >1 publications with ELMO1 and Muscle
 Thymus Antibodies  >1 publications with ELMO1 and Thymus
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