Human EPB41 cDNA Clone Expression Plasmid – Cat# MBS1266926

EPB41 cDNA Clone – Erythrocyte Membrane Protein Band 4.1 (Elliptocytosis 1, Rh-Linked) (Human)

Name: EPB41 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1266926
Price: 820 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1266926

MBS1266926 is a cDNA clone targeting EPB41. More details

$820 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

EPB41, cDNA Clone

Full Product Name

EPB41 cDNA Clone

Product Gene Name

EPB41 cdna clone

Sequence

atgacaacag agaagagttt agtgactgag gccgaaaatt cacagcacca acagaaggaa gagggtgagg aagccataaa ctcaggccaa caagaacctc agcaggagga atcttgtcaa acagcagctg aaggagataa ttggtgtgaa cagaagctga aagcttctaa tggagacact cctacacatg aagacttgac caagaacaag gagcggacat cagaaagcag aggactttca cgactattct cctcgtttct caaaaggccc aaatctcagg tgtccgagga agaaggcaaa gaagtagagt cagataaaga aaaaggtgaa ggaggtcaga aagagataga atttggaacc agtcttgatg aagagatcat tttaaaggcc ccaattgcag ctcctgaacc ggaactcaaa acagacccat ctttggatct tcattcatta agcagtgcag aaacacagcc tgctcaggaa gaactcagag aagatccaga ttttgaaatt aaggaaggag aaggacttga agagtgctcc aaaatagaag taaaagaaga aagccctcaa tcaaaagcag aaacagaatt aaaagcttcc caaaaaccaa tcagaaaaca caggaacatg cactgcaagg tttctttgtt ggatgacaca gtttatgaat gtgttgtgga gaaacatgct aagggacaag atttgcttaa acgagtatgt gagcatctca atcttttgga agaagactat tttggtctag ccatttggga taacgcaacc tctaagacat ggctggattc cgccaaagaa ataaaaaagc aggttcgtgg tgtcccttgg aattttacat ttaatgtaaa gttttatcca cctgacccag cacagttaac agaagacata acaagatatt atttatgtct tcagcttcgg caggacatag ttgcaggacg tctgccctgt tcctttgcaa ccttagcatt attaggttct tacaccatcc agtctgaact gggagactac gacccagaac tccatggcgt ggattatgtt agtgatttta aactggcccc gaatcagacc aaggaacttg aagagaaggt catggaactg cataagtcat acaggtccat gactccagct caggctgact tggagtttct tgagaatgcc aaaaagttgt ctatgtatgg agttgatctt cataaagcaa aggacttgga aggagtagat atcatcctag gtgtctgctc tagtggcctt ctggtttaca aagataagct gagaattaac cgcttccctt ggcccaaagt gctgaagatt tcttataaac gtagtagctt tttcatcaag attcggcctg gagagcaaga gcagtatgaa agtaccatcg gattcaaact tcccagttac cgagcagcta agaaattatg gaaagtctgt gtagaacatc acacgttttt cagattgaca tctacagaca ccattcccaa aagcaaattt cttgcgctag gatccaaatt tcgatacagt ggccggactc aagctcagac caggcaagct agtgctctaa ttgacaggcc tgccccacac ttcgagcgta cagcaagtaa acgggcgtcc cggagcctcg atggagcagc agctgtcgat tcggcagacc gaagtcctcg gcccacttct gcacctgcca ttactcaggg tcaggttgca gaaggtggcg tcctagatgc ctctgctaaa aaaacagtgg tccctaaagc acagaaggaa acagtgaagg ctgaagtgaa aaaggaagac gagccacctg agcaagctga gccagagccc acagaagcat ggaaggtgga aaaaacccac atcgaggtga cagtacccac ctcaaatggt gaccaaacac agaaaaagag agaaagacta gatggtgaaa acatttatat cagacatagc aatttaatgt tggaggattt agacaagagt caagaggaga tcaaaaaaca tcatgccagc atcagtgagc tgaaaaagaa cttcatggag tctgtaccag aaccacggcc tagtgaatgg gataaacgct tatccactca ctcacccttc cgaactctta acatcaatgg gcaaatcccc acaggagaag gagtgagtac tttgtccaca tga

Molecular Weight

81,235 Da

OMIM

130500

Vector

Please Inquire

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of EPB41 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for EPB41. It may not necessarily be applicable to this product.

NCBI GI #

24657822

NCBI GeneID

2035

NCBI Accession #

BC039079

UniProt Secondary Accession #

P11176; Q14245; Q5TB35; Q5VXN8; Q8IXV9; Q9Y578; Q9Y579; B1ALH8; B1ALH9; D3DPM9; D3DPN0

UniProt Related Accession #

P11171

NCBI Official Full Name

Homo sapiens erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked), mRNA

NCBI Official Synonym Full Names

erythrocyte membrane protein band 4.1

NCBI Official Symbol

EPB41

NCBI Official Synonym Symbols

HE; EL1; 4.1R

UniProt Protein Name

Protein 4.1

UniProt Synonym Protein Names

4.1R; Band 4.1; EPB4.1

Protein Family

Cytoskeletal protein

UniProt Gene Name

EPB41

UniProt Synonym Gene Names

E41P; P4.1

UniProt Entry Name

41_HUMAN

NCBI Protein Information

protein 4.1

NCBI Summary for EPB41

The protein encoded by this gene, together with spectrin and actin, constitute the red cell membrane cytoskeletal network. This complex plays a critical role in erythrocyte shape and deformability. Mutations in this gene are associated with type 1 elliptocytosis (EL1). Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Oct 2009]

UniProt Comments for EPB41

EPB41: Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Defects in EPB41 are the cause of elliptocytosis type 1 (EL1). EL1 is a Rhesus-linked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant, hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape. Defects in EPB41 are a cause of hereditary pyropoikilocytosis (HPP). HPP is an autosomal recessive hematologic disorder characterized by hemolytic anemia, microspherocytosis, poikilocytosis, and an unusual thermal sensitivity of red cells. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 1p33-p32

Cellular Component: cell junction; cortical cytoskeleton; cytoplasm; plasma membrane; protein complex; spectrin

Molecular Function: phosphatidylinositol binding; protein binding; spectrin binding; structural constituent of cytoskeleton

Biological Process: actomyosin structure organization and biogenesis; blood circulation; positive regulation of protein binding

Disease: Elliptocytosis 1; Pyropoikilocytosis, Hereditary

Research Articles on EPB41

1. The 4.1R, 4.1N and 4.1B are all expressed at the lateral membrane as well as cytoplasm of epithelial cells, suggesting a potentially redundant role of these proteins.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with EPB41 cdna clone

Products by Pathway	Pathway Diagram
Syndecan-2-mediated Signaling Events Pathway antibodies	Syndecan-2-mediated Signaling Events Pathway Diagram
Tight Junction Pathway antibodies	Tight Junction Pathway Diagram
Tight Junction Pathway antibodies	Tight Junction Pathway Diagram

Diseases associated with EPB41 cdna clone

Disease Name	Pubmed Publications
Anemia, Hemolytic Antibodies	>3 publications with EPB41 and Anemia, Hemolytic
Anemia Antibodies	>3 publications with EPB41 and Anemia
Elliptocytosis 1 Antibodies	>3 publications with EPB41 and Elliptocytosis 1
Neoplasms Antibodies	>2 publications with EPB41 and Neoplasms

Organs/Tissues associated with EPB41 cdna clone

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>9 publications with EPB41 and Blood
Brain Antibodies	>2 publications with EPB41 and Brain
Muscle Antibodies	>1 publications with EPB41 and Muscle
Heart Antibodies	>1 publications with EPB41 and Heart
Uncharacterized Tissue Antibodies	>1 publications with EPB41 and Uncharacterized Tissue
Prostate Antibodies	>1 publications with EPB41 and Prostate