Human ERBB4 cDNA Clone Expression Plasmid – Cat# MBS1277448

ERBB4 cDNA Clone – V-Erb-a Erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (Human)

Name: ERBB4 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1277448
Price: 1625 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1277448

MBS1277448 is a cDNA clone targeting ERBB4. More details

$1625 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +2 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ERBB4, cDNA Clone

Full Product Name

ERBB4 cDNA Clone

Product Gene Name

ERBB4 cdna clone

Sequence

atgaagccgg cgacaggact ttgggtctgg gtgagccttc tcgtggcggc ggggaccgtc cagcccagcg attctcagtc agtgtgtgca ggaacggaga ataaactgag ctctctctct gacctggaac agcagtaccg agccttgcgc aagtactatg aaaactgtga ggttgtcatg ggcaacctgg agataaccag cattgagcac aaccgggacc tctccttcct gcggtctgtt cgagaagtca caggctacgt gttagtggct cttaatcagt ttcgttacct gcctctggag aatttacgca ttattcgtgg gacaaaactt tatgaggatc gatatgcctt ggcaatattt ttaaactaca gaaaagatgg aaactttgga cttcaagaac ttggattaaa gaacttgaca gaaatcctaa atggtggagt ctatgtagac cagaacaaat tcctttgtta tgcagacacc attcattggc aagatattgt tcggaaccca tggccttcca acttgactct tgtgtcaaca aatggtagtt caggatgtgg acgttgccat aagtcctgta ctggccgttg ctggggaccc acagaaaatc attgccagac tttgacaagg acggtgtgtg cagaacaatg tgacggcaga tgctacggac cttacgtcag tgactgctgc catcgagaat gtgctggagg ctgctcagga cctaaggaca cagactgctt tgcctgcatg aatttcaatg acagtggagc atgtgttact cagtgtcccc aaacctttgt ctacaatcca accacctttc aactggagca caatttcaat gcaaagtaca catatggagc attctgtgtc aagaaatgtc cacataactt tgtggtagat tccagttctt gtgtgcgtgc ctgccctagt tccaagatgg aagtagaaga aaatgggatt aaaatgtgta aaccttgcac tgacatttgc ccaaaagctt gtgatggcat tggcacagga tcattgatgt cagctcagac tgtggattcc agtaacattg acaaattcat aaactgtacc aagatcaatg ggaatttgat ctttctagtc actggtattc atggggaccc ttacaatgca attgaagcca tagacccaga gaaactgaac gtctttcgga cagtcagaga gataacaggt ttcctgaaca tacagtcatg gccaccaaac atgactgact tcagtgtttt ttctaacctg gtgaccattg gtggaagagt actctatagt ggcctgtcct tgcttatcct caagcaacag ggcatcacct ctctacagtt ccagtccctg aaggaaatca gcgcaggaaa catctatatt actgacaaca gcaacctgtg ttattatcat accattaact ggacaacact cttcagcaca atcaaccaga gaatagtaat ccgggacaac agaaaagctg aaaattgtac tgctgaagga atggtgtgca accatctgtg ttccagtgat ggctgttggg gacctgggcc agaccaatgt ctgtcgtgtc gccgcttcag tagaggaagg atctgcatag agtcttgtaa cctctatgat ggtgaatttc gggagtttga gaatggctcc atctgtgtgg agtgtgaccc ccagtgtgag aagatggaag atggcctcct cacatgccat ggaccgggtc ctgacaactg tacaaagtgc tctcatttta aagatggccc aaactgtgtg gaaaaatgtc cagatggctt acagggggca aacagtttca ttttcaagta tgctgatcca gatcgggagt gccacccatg ccatccaaac tgcacccaag ggtgtaacgg tcccactagt catgactgca tttactaccc atggacgggc cattccactt taccacaaca tgctagaact cccctgattg cagctggagt aattggtggg ctcttcattc tggtcattgt gggtctgaca tttgctgttt atgttagaag gaagagcatc aaaaagaaaa gagccttgag aagattcttg gaaacagagt tggtggaacc attaactccc agtggcacag cacccaatca agctcaactt cgtattttga aagaaactga gctgaagagg gtaaaagtcc ttggctcagg tgcttttgga acggtttata aaggtatttg ggtacctgaa ggagaaactg tgaagattcc tgtggctatt aagattctta atgagacaac tggtcccaag gcaaatgtgg agttcatgga tgaagctctg atcatggcaa gtatggatca tccacaccta gtccggttgc tgggtgtgtg tctgagccca accatccagc tggttactca acttatgccc catggctgcc tgttggagta tgtccacgag cacaaggata acattggatc acaactgctg cttaactggt gtgtccagat agctaaggga atgatgtacc tggaagaaag acgactcgtt catcgggatt tggcagcccg taatgtctta gtgaaatctc caaaccatgt gaaaatcaca gattttgggc tagccagact cttggaagga gatgaaaaag agtacaatgc tgatggagga aagatgccaa ttaaatggat ggctctggag tgtatacatt acaggaaatt cacccatcag agtgacgttt ggagctatgg agttactata tgggaactga tgacctttgg aggaaaaccc tatgatggaa ttccaacgcg agaaatccct gatttattag agaaaggaga acgtttgcct cagcctccca tctgcactat tgacgtttac atggtcatgg tcaaatgttg gatgattgat gctgacagta gacctaaatt taaggaactg gctgctgagt tttcaaggat ggctcgagac cctcaaagat acctagttat tcagggtgat gatcgtatga agcttcccag tccaaatgac agcaagttct ttcagaatct cttggatgaa gaggatttgg aagatatgat ggatgctgag gagtacttgg tccctcaggc tttcaacatc ccacctccca tctatacttc cagagcaaga attgactcga ataggagtga aattggacac agccctcctc ctgcctacac ccccatgtca ggaaaccagt ttgtataccg agatggaggt tttgctgctg aacaaggagt gtctgtgccc tacagagccc caactagcac aattccagaa gctcctgtgg cacagggtgc tactgctgag atttttgatg actcctgctg taatggcacc ctacgcaagc cagtggcacc ccatgtccaa gaggacagta gcacccagag gtacagtgct gaccccaccg tgtttgcccc agaacggagc ccacgaggag agctggatga ggaaggttac atgactccta tgcgagacaa acccaaacaa gaatacctga atccagtgga ggagaaccct tttgtttctc ggagaaaaaa tggagacctt caagcattgg ataatcccga atatcacaat gcatccaatg gtccacccaa ggccgaggat gagtatgtga atgagccact gtacctcaac acctttgcca acaccttggg aaaagctgag tacctgaaga acaacatact gtcaatgcca gagaaggcca agaaagcgtt tgacaaccct gactactgga accacagcct gccacctcgg agcacccttc agcacccaga ctacctgcag gagtacagca caaaatattt ttataaacag aatgggcgga tccggcctat tgtggcagag aatcctgaat acctctctga gttctccctg aagccaggca ctgtgctgcc gcctccacct tacagacacc ggaatactgt ggtgtaa

Molecular Weight

143,968 Da

OMIM

600543

Vector

Please Inquire

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of ERBB4 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ERBB4. It may not necessarily be applicable to this product.

NCBI GI #

85566879

NCBI GeneID

2066

NCBI Accession #

BC112199

UniProt Secondary Accession #

Q2M1W1; Q59EW4; B7ZLD7; B7ZLE2; B7ZLE3

UniProt Related Accession #

Q15303

NCBI Official Full Name

Homo sapiens v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian), mRNA

NCBI Official Synonym Full Names

erb-b2 receptor tyrosine kinase 4

NCBI Official Symbol

ERBB4

NCBI Official Synonym Symbols

HER4; ALS19; p180erbB4

UniProt Protein Name

Receptor tyrosine-protein kinase erbB-4

UniProt Synonym Protein Names

Proto-oncogene-like protein c-ErbB-4; Tyrosine kinase-type cell surface receptor HER4; p180erbB4

Protein Family

Receptor tyrosine-protein kinase

UniProt Gene Name

ERBB4

UniProt Synonym Gene Names

HER4; 4ICD; E4ICD

UniProt Entry Name

ERBB4_HUMAN

NCBI Protein Information

receptor tyrosine-protein kinase erbB-4

NCBI Summary for ERBB4

This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

UniProt Comments for ERBB4

HER4: a receptor tyrosine kinase of the EGFR family. Specifically binds and is activated by neuregulins, NRG- 2, NRG-3, heparin-binding EGF-like growth factor, betacellulin and NTAK. Heterodimerizes and signals with other EGF receptors. Interaction with these factors induces cell differentiation. Not activated by EGF, TGF-A, and amphiregulin. Interacts with PDZ domains of DLG2, DLG3, DLG4 and the syntrophin SNTB2. Interacts with WWOX. May act as a tumor suppressor: overexpressed in head and neck cancer , but downregulated in renal cancer, papillary carcinoma, high-grade gliomas and invasive breast cancer. 3 alternatively-spliced isoforms of the human protein have been reported.

Protein type: Kinase, protein; Membrane protein, integral; EC 2.7.10.1; Protein kinase, tyrosine (receptor); Protein kinase, TK; TK group; EGFR family

Chromosomal Location of Human Ortholog: 2q33.3-q34

Cellular Component: basolateral plasma membrane; cytosol; extracellular region; mitochondrial matrix; mitochondrion; nucleoplasm; nucleus; plasma membrane; receptor complex

Molecular Function: epidermal growth factor receptor binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein binding; protein homodimerization activity; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity; transmembrane receptor protein tyrosine kinase activity

Biological Process: cell migration; cell proliferation; central nervous system morphogenesis; embryonic pattern specification; heart development; lactation; MAPKKK cascade; mitochondrial fragmentation during apoptosis; negative regulation of cell proliferation; nervous system development; neural crest cell migration; olfactory bulb interneuron differentiation; peptidyl-tyrosine phosphorylation; phosphoinositide-mediated signaling; positive regulation of cardiac muscle cell proliferation; positive regulation of cell proliferation; positive regulation of protein amino acid phosphorylation; positive regulation of transcription, DNA-dependent; positive regulation of tyrosine phosphorylation of Stat5 protein; protein amino acid autophosphorylation; regulation of cell migration; regulation of phosphoinositide 3-kinase cascade; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway

Disease: Amyotrophic Lateral Sclerosis 19

Research Articles on ERBB4

1. nuclear HER4 seem to be co-located with estrogen receptors, however, we did not find support for overall HER4 expression in independently predicting response of tamoxifen treatment in breast cancer

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with ERBB4 cdna clone

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Calcium Signaling Pathway antibodies	Calcium Signaling Pathway Diagram
Calcium Signaling Pathway antibodies	Calcium Signaling Pathway Diagram
Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies	Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
DAP12 Interactions Pathway antibodies	DAP12 Interactions Pathway Diagram
DAP12 Signaling Pathway antibodies	DAP12 Signaling Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
Downregulation Of ERBB4 Signaling Pathway antibodies	Downregulation Of ERBB4 Signaling Pathway Diagram
Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies	Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram
Downstream Signal Transduction Pathway antibodies	Downstream Signal Transduction Pathway Diagram

Diseases associated with ERBB4 cdna clone

Disease Name	Pubmed Publications
Neoplasms Antibodies	>257 publications with ERBB4 and Neoplasms
Carcinoma Antibodies	>90 publications with ERBB4 and Carcinoma
Nervous System Diseases Antibodies	>56 publications with ERBB4 and Nervous System Diseases
Heart Diseases Antibodies	>33 publications with ERBB4 and Heart Diseases
Adenocarcinoma Antibodies	>32 publications with ERBB4 and Adenocarcinoma
Neoplasms, Experimental Antibodies	>30 publications with ERBB4 and Neoplasms, Experimental
Brain Diseases Antibodies	>29 publications with ERBB4 and Brain Diseases
Necrosis Antibodies	>24 publications with ERBB4 and Necrosis
Lung Neoplasms Antibodies	>24 publications with ERBB4 and Lung Neoplasms
Lung Diseases Antibodies	>23 publications with ERBB4 and Lung Diseases

Organs/Tissues associated with ERBB4 cdna clone

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>209 publications with ERBB4 and Brain
Heart Antibodies	>83 publications with ERBB4 and Heart
Muscle Antibodies	>75 publications with ERBB4 and Muscle
Lung Antibodies	>57 publications with ERBB4 and Lung
Embryonic Tissue Antibodies	>46 publications with ERBB4 and Embryonic Tissue
Mammary Gland Antibodies	>33 publications with ERBB4 and Mammary Gland
Kidney Antibodies	>21 publications with ERBB4 and Kidney
Pancreas Antibodies	>13 publications with ERBB4 and Pancreas
Uterus Antibodies	>11 publications with ERBB4 and Uterus
Ovary Antibodies	>8 publications with ERBB4 and Ovary