Human EYA2 cDNA Clone Expression Plasmid – Cat# MBS1272638

EYA2 cDNA Clone – Eyes Absent Homolog 2 (Drosophila) (Human)

Name: EYA2 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1272638
Price: 400 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1272638

MBS1272638 is a cDNA clone targeting EYA2. More details

$400 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

EYA2, cDNA Clone

Full Product Name

EYA2 cDNA Clone

Product Gene Name

EYA2 cdna clone

Sequence

atggtagaac tagtgatctc acccagcctc actgtaaaca gcgattgtct ggataaactg aagtttaacc gtgctgacgc tgctgtgtgg actctgagtg acagacaagg catcaccaaa tcggcccccc tgagagtgtc ccagctcttc tccagatctt gcccacgtgt cctcccccgc cagccttcca cagccatggc agcctacggc cagacgcagt acagtgcggg gatccagcag gctaccccct atacagctta cccacctcca gcacaagcct atggaatccc ttccttcagc acctcaccca ctggacagag cccatacacc taccagatgc acggcacaac agggttctat caaggaggaa atggactggg caacgcagcc ggtttcggga gtgtgcacca ggactatcct tcctaccccg gcttccccca gagccagtac ccccagtatt acggctcatc ctacaaccct ccctacgtcc cggccagcag catctgccct tcgcccctct ccacgtccac ctacgtcctc caggaggcat ctcacaacgt ccccaaccag agttccgagt cacttgctgg tgaatacaac acacacaatg gaccttccac accagcgaaa gagggagaca cagacaggcc gcaccgggcc tccgacggga agctccgagg ccggtctaag aggagcagtg acccgtcccc ggcaggggac aatgagattg agcgtgtgtt cgtgtgggac ttggatgaga caataattat ttttcactcc ttactcacgg ggacatttgc atccagatac gggaaggaca ccacgacgtc cgtgcgcatt ggccttatga tggaagagat gatcttcaac cttgcagata cacatctgtt cttcaatgac ctggaggatt gtgaccagat ccacgttgat gacgtctcat cagatgacaa tggccaagat ttaagcacat acaacttctc cgctgacggc ttccacagtt cggccccagc agccaacctg tgcctgggct ctggcgtgca cggcggcgtg gactggatga ggaagctggc cttccgctac cggcgggtga aggagatgta caatacctac aagaacaacg ttggtgggtt gataggcact cccaaaaggg agacctggct acagctccga gctgagctgg aagctctcac agacctctgg ctgacccact ccctgaaggc actaaacctc atcaactccc ggcccaactg tgtcaatgtg ctggtcacca ccactcaact aattcctgcc ctggccaaag tcctgctata tggcctgggg tctgtgtttc ctattgagaa catctacagt gcaaccaaga cagggaagga gagctgcttc gagaggataa tgcagagatt cggcagaaaa gctgtctacg tggtgatcgg tgatggtgtg gaagaggagc aaggagcgaa aaagcacaac atgcctttct ggcggatatc ctgccacgca gacctggagg cactgaggca cgccctggag ctggagtatt tatag

Molecular Weight

50,533 Da

OMIM

601654

Vector

pENTR223.1 or pUC

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of EYA2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for EYA2. It may not necessarily be applicable to this product.

NCBI GI #

33871141

NCBI GeneID

2139

NCBI Accession #

BC008803

UniProt Secondary Accession #

Q5JSW8; Q86U84; Q96CV6; Q96H97; Q99503; Q99812; Q9BWF6; Q9H4S3; Q9H4S9; Q9NPZ4; Q9UIX7

UniProt Related Accession #

O00167

NCBI Official Full Name

Homo sapiens eyes absent homolog 2 (Drosophila), mRNA

NCBI Official Synonym Full Names

EYA transcriptional coactivator and phosphatase 2

NCBI Official Symbol

EYA2

NCBI Official Synonym Symbols

EAB1

UniProt Protein Name

Eyes absent homolog 2

Protein Family

Eyes absent

UniProt Gene Name

EYA2

UniProt Synonym Gene Names

EAB1

UniProt Entry Name

EYA2_HUMAN

NCBI Protein Information

eyes absent homolog 2

NCBI Summary for EYA2

This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may be post-translationally modified and may play a role in eye development. A similar protein in mice can act as a transcriptional activator. Alternative splicing results in multiple transcript variants, but the full-length natures of all of these variants have not yet been determined. [provided by RefSeq, Jul 2009]

UniProt Comments for EYA2

EYA2: Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1. Seems to coactivate SIX2, SIX4 and SIX5. Together with SIX1 and DACH2 seem to be involved in myogenesis. May be involved in development of the eye. Interaction with GNAZ and GNAI2 prevents nuclear translocation and transcriptional activity. Belongs to the HAD-like hydrolase superfamily. EYA family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein phosphatase, tyrosine (non-receptor); EC 3.1.3.48; Cell development/differentiation; Apoptosis

Chromosomal Location of Human Ortholog: 20q13.1

Cellular Component: nucleoplasm

Molecular Function: magnesium ion binding; protein binding; protein tyrosine phosphatase activity

Biological Process: histone dephosphorylation; mesodermal cell fate specification

Research Articles on EYA2

1. SIX1 and EYA are often co-overexpressed in tumors, and the SIX1-EYA2 interaction has been shown to be critical for metastasis in a breast cancer model.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with EYA2 cdna clone

Disease Name	Pubmed Publications
Congenital Abnormalities Antibodies	>6 publications with EYA2 and Congenital Abnormalities
Eye Abnormalities Antibodies	>4 publications with EYA2 and Eye Abnormalities
Hypertrophy Antibodies	>3 publications with EYA2 and Hypertrophy
Nervous System Diseases Antibodies	>3 publications with EYA2 and Nervous System Diseases
Necrosis Antibodies	>3 publications with EYA2 and Necrosis
Eye Diseases Antibodies	>2 publications with EYA2 and Eye Diseases
Heart Diseases Antibodies	>2 publications with EYA2 and Heart Diseases
Drug Toxicity Antibodies	>2 publications with EYA2 and Drug Toxicity
Fibrosis Antibodies	>2 publications with EYA2 and Fibrosis
Inflammation Antibodies	>2 publications with EYA2 and Inflammation