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FCGR2B cDNA Clone – Of IgG, Low Affinity Iib, Receptor (CD32) (Human)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1271516

MBS1271516 is a cDNA clone targeting FCGR2B. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
FCGR2B, cDNA Clone
Full Product Name
FCGR2B cDNA Clone
Product Gene Name
FCGR2B cdna clone
Sequence
ATGGGAATCC TGTCATTCTT ACCTGTCCTT GCCACTGAGA GTGACTGGGC TGACTGCAAG TCCCCCCAGC CTTGGGGTCA TATGCTTCTG TGGACAGCTG TGCTATTCCT GGCTCCTGTT GCTGGGACAC CTGCAGCTCC CCCAAAGGCT GTGCTGAAAC TCGAGCCCCA GTGGATCAAC GTGCTCCAGG AGGACTCTGT GACTCTGACA TGCCGGGGGA CTCACAGCCC TGAGAGCGAC TCCATTCAGT GGTTCCACAA TGGGAATCTC ATTCCCACCC ACACGCAGCC CAGCTACAGG TTCAAGGCCA ACAACAATGA CAGCGGGGAG TACACGTGCC AGACTGGCCA GACCAGCCTC AGCGACCCTG TGCATCTGAC TGTGCTTTCT GAGTGGCTGG TGCTCCAGAC CCCTCACCTG GAGTTCCAGG AGGGAGAAAC CATCGTGCTG AGGTGCCACA GCTGGAAGGA CAAGCCTCTG GTCAAGGTCA CATTCTTCCA GAATGGAAAA TCCAAGAAAT TTTCCCGTTC GGATCCCAAC TTCTCCATCC CACAAGCAAA CCACAGTCAC AGTGGTGATT ACCACTGCAC AGGAAACATA GGCTACACGC TGTACTCATC CAAGCCTGTG ACCATCACTG TCCAAGCTCC CAGCTCTTCA CCGATGGGGA TCATTGTGGC TGTGGTCACT GGGACTGCTG TAGCGGCCAT TGTTGCTGCT GTAGTGGCCT TGATCTACTG CAGGAAAAAG CGGATTTCAG CCAATCCCAC TAATCCTGAT GAGGCTGACA AAGTTGGGGC TGAGAACACA ATCACCTATT CACTTCTCAT GCACCCGGAT GCTCTGGAAG AGCCTGATGA CCAGAACCGT ATTTAG
Molecular Weight
33,450 Da
OMIM
152700
Vector
pENTR223.1 or pUC
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of FCGR2B cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for FCGR2B. It may not necessarily be applicable to this product.

NCBI GI #
146327027
NCBI GeneID
2213
NCBI Accession #
BC141826
UniProt Secondary Accession #
O95649; Q53X85; Q5VXA9; Q8NIA1; A6H8N3
UniProt Related Accession #
P31994
NCBI Official Full Name
Homo sapiens Fc fragment of IgG, low affinity IIb, receptor (CD32), mRNA
NCBI Official Synonym Full Names
Fc fragment of IgG receptor IIb
NCBI Official Symbol
FCGR2B
NCBI Official Synonym Symbols
CD32; FCG2; CD32B; FCGR2; IGFR2
UniProt Protein Name
Low affinity immunoglobulin gamma Fc region receptor II-b
UniProt Synonym Protein Names
CDw32; Fc-gamma RII-b; Fc-gamma-RIIb; FcRII-b; CD_antigen: CD32
Protein Family
Low affinity immunoglobulin gamma Fc region receptor
UniProt Gene Name
FCGR2B
UniProt Synonym Gene Names
CD32; FCG2; IGFR2; IgG Fc receptor II-b; Fc-gamma-RIIb; FcRII-b
UniProt Entry Name
FCG2B_HUMAN
NCBI Protein Information
low affinity immunoglobulin gamma Fc region receptor II-b

NCBI Summary for FCGR2B

The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
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UniProt Comments for FCGR2B

FCGR2B: a transmembrane receptor for the Fc region of complexed or aggregated immunoglobulin gamma (IgG). Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down modulation of previous state of cell activation triggered via antigen receptors on B cells, T cells or via another Fc receptor. Three splice-variant isoforms have been observed.

Protein type: Cell surface; Membrane protein, integral; Oncoprotein

Chromosomal Location of Human Ortholog: 1q23

Cellular Component: plasma membrane

Molecular Function: protein binding

Biological Process: immune response; regulation of immune response; signal transduction

Disease: Malaria, Susceptibility To; Systemic Lupus Erythematosus
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Research Articles on FCGR2B

1. LPS activation of TLR4 significantly increased MARCH3 expression and that siRNA against MARCH3 prevented the decrease in FcgammaRIIb following LPS treatment.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with FCGR2B cdna clone

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BCR Signaling Pathway antibodies  BCR Signaling Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 Fc-epsilon Receptor I Signaling In Mast Cells Pathway antibodies  Fc-epsilon Receptor I Signaling In Mast Cells Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram

Diseases associated with FCGR2B cdna clone

 Disease Name  Pubmed Publications
 Autoimmune Diseases Antibodies  >113 publications with FCGR2B and Autoimmune Diseases
 Lupus Erythematosus, Systemic Antibodies  >62 publications with FCGR2B and Lupus Erythematosus, Systemic
 Inflammation Antibodies  >45 publications with FCGR2B and Inflammation
 Neoplasms Antibodies  >23 publications with FCGR2B and Neoplasms
 Kidney Diseases Antibodies  >22 publications with FCGR2B and Kidney Diseases
 Nervous System Diseases Antibodies  >14 publications with FCGR2B and Nervous System Diseases
 Necrosis Antibodies  >13 publications with FCGR2B and Necrosis
 Brain Diseases Antibodies  >5 publications with FCGR2B and Brain Diseases
 Liver Diseases Antibodies  >3 publications with FCGR2B and Liver Diseases
 Malaria Antibodies  >3 publications with FCGR2B and Malaria

Organs/Tissues associated with FCGR2B cdna clone

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >157 publications with FCGR2B and Blood
 Spleen Antibodies  >25 publications with FCGR2B and Spleen
 Bone Marrow Antibodies  >17 publications with FCGR2B and Bone Marrow
 Lymph Node Antibodies  >16 publications with FCGR2B and Lymph Node
 Kidney Antibodies  >14 publications with FCGR2B and Kidney
 Lung Antibodies  >8 publications with FCGR2B and Lung
 Brain Antibodies  >8 publications with FCGR2B and Brain
 Liver Antibodies  >5 publications with FCGR2B and Liver
 Connective Tissue Antibodies  >2 publications with FCGR2B and Connective Tissue
 Skin Antibodies  >2 publications with FCGR2B and Skin
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