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FGFR1OP cDNA Clone – FGFR1 Oncogene Partner (Human)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1269232

MBS1269232 is a cDNA clone targeting FGFR1OP. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
FGFR1OP, cDNA Clone
Full Product Name
FGFR1OP cDNA Clone
Product Gene Name
FGFR1OP cdna clone
Sequence
atggcggcga cggcggccgc agtggtggcc gaggaggaca cggagctgcg ggacctgctg gtgcagacgc tggagaacag cggggtcctg aaccgcatca aggctgaact ccgagcagct gtgtttttag cactagagga gcaagaaaaa gtagagaaca aaactccttt agttaatgag agcctgagaa agtttttaaa taccaaagac ggtcgtttag tggctagtct tgttgcagaa tttcttcagt tttttaacct tgactttact ttggctgttt ttcaacctga aactagcaca ctgcaaggtc tcgaaggtcg agagaattta gcccgagatt taggtataat tgaagcagaa ggtactgtgg gtggaccctt attattagaa gtgatcaggc gctgtcaaca gaaagaaaaa gggccaacca ctggggaagg tgcacttgat ctatctgatg tacattctcc accaaagtca ccagagggaa aaacaagtgc acagacaaca ccaagtaaga aggccaatga tgaggccaat cagagtgata caagtgtctc cttgtcagaa cccaagagca aaagcagcct tcacttactg tcccatgaaa caaaaattgg atcttttcta agcaacagaa ctttagatgg caaagacaaa gctggccttt gtccagatga agatgatatg gaaggagatt ctttctttga tgatcccatt cctaagccag agaaaactta cggtttgagg aatgaaccta ggaagcaagc aggaagtctg gcctcgctct cggatgcacc ccccttaaaa agtggactca gctccctggc gggagcccct tctttaaaag actctgagag taaaagggga aatacagttt tgaaagatct gaaattgatc agtgataaaa ttggatcact tggattagga actggagaag atgatgacta tgttgatgat tttaatagta ccagccatcg ctcagagaaa agtgagataa gtattggtga agagatagaa gaagaccttt ctgtggaaat agatgacatc aataccagtg ataagcttga tgacctcaca caagatctga ctgtatccca gctcagtgat gttgcggatt atctggaaga tgttgcatag
Molecular Weight
16,106 Da
OMIM
605392
Vector
pENTR223.1 or pUC
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of FGFR1OP cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for FGFR1OP. It may not necessarily be applicable to this product.

NCBI GI #
40225858
NCBI GeneID
11116
NCBI Accession #
BC011902
UniProt Secondary Accession #
Q49AI0; Q5R3F6; Q96EW1; A8K1D1; B2R705
UniProt Related Accession #
O95684
NCBI Official Full Name
Homo sapiens FGFR1 oncogene partner, mRNA
NCBI Official Synonym Full Names
FGFR1 oncogene partner
NCBI Official Symbol
FGFR1OP
NCBI Official Synonym Symbols
FOP
UniProt Protein Name
FGFR1 oncogene partner
Protein Family
FGFR1 oncogene partner
UniProt Gene Name
FGFR1OP
UniProt Synonym Gene Names
FOP
UniProt Entry Name
FR1OP_HUMAN
NCBI Protein Information
FGFR1 oncogene partner

NCBI Summary for FGFR1OP

This gene encodes a largely hydrophilic centrosomal protein that is required for anchoring microtubules to subcellular structures. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. Alterations in this gene may also be associated with Crohn's disease, Graves' disease, and vitiligo. Alternatively spliced transcript variants that encode different proteins have been identified. [provided by RefSeq, Jul 2013]
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UniProt Comments for FGFR1OP

FOP: Required for anchoring microtubules to the centrosomes. A chromosomal aberration involving FGFR1OP may be a cause of stem cell myeloproliferative disorder (MPD). Translocation t(6;8)(q27;p11) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion proteins FGFR1OP-FGFR1 or FGFR1-FGFR1OP may exhibit constitutive kinase activity and be responsible for the transforming activity. Belongs to the FGFR1OP family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 6q27

Cellular Component: centrosome; cytosol; nucleus; perinuclear region of cytoplasm

Molecular Function: protein binding; protein homodimerization activity; protein kinase binding; protein tyrosine kinase inhibitor activity; protein-tyrosine kinase activity

Biological Process: G2/M transition of mitotic cell cycle; negative regulation of protein kinase activity; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell proliferation
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Research Articles on FGFR1OP

1. The rs151606 T>G was associated with an increased risk of lung cancer and rs12212247 T>C was associated with a decreased risk of lung cancer

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with FGFR1OP cdna clone

 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Centrosome Maturation Pathway antibodies  Centrosome Maturation Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G2/M Transition Pathway antibodies  G2/M Transition Pathway Diagram
 Loss Of Nlp From Mitotic Centrosomes Pathway antibodies  Loss Of Nlp From Mitotic Centrosomes Pathway Diagram
 Loss Of Proteins Required For Interphase Microtubule Organization From The Centrosome Pathway antibodies  Loss Of Proteins Required For Interphase Microtubule Organization From The Centrosome Pathway Diagram
 Mitotic G2-G2/M Phases Pathway antibodies  Mitotic G2-G2/M Phases Pathway Diagram
 Recruitment Of Mitotic Centrosome Proteins And Complexes Pathway antibodies  Recruitment Of Mitotic Centrosome Proteins And Complexes Pathway Diagram
 Signaling By FGFR In Disease Pathway antibodies  Signaling By FGFR In Disease Pathway Diagram

Diseases associated with FGFR1OP cdna clone

 Disease Name  Pubmed Publications
 Hyperplasia Antibodies  >3 publications with FGFR1OP and Hyperplasia
 Atrophy Antibodies  >2 publications with FGFR1OP and Atrophy
 Lung Neoplasms Antibodies  >1 publications with FGFR1OP and Lung Neoplasms
 Epstein-Barr Virus Infections Antibodies  >1 publications with FGFR1OP and Epstein-Barr Virus Infections
 Neoplasms, Experimental Antibodies  >1 publications with FGFR1OP and Neoplasms, Experimental
 Cell Transformation, Neoplastic Antibodies  >1 publications with FGFR1OP and Cell Transformation, Neoplastic
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