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FKBP3 cDNA Clone – Peptidyl-Prolyl Cis-Trans Isomerase FKBP3

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS200525

FK506 binding protein 3 (FKBP3), also known as FKBP25, is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. FKBP3 associates with transcriptional… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
FKBP3, cDNA Clone
Full Product Name
FKBP3
Product Gene Name
FKBP3 cdna clone
Product Synonym Names
FKBP-25; FKBP-3; FKBP25; PPIase
Sequence
Nucleotide Sequence: ATGGCGGCGG CCGTTCCACA GCGGGCGTGG ACCGTGGAGC AGCTGCGCAG TGAGCAGCTG CCCAAGAAGG ACATTATCAA GTTTCTGCAG GAACACGGTT CAGATTCGTT TCTTGCAGAA CATAAATTAT TAGGAAACAT TAAAAATGTG GCCAAGACAG CTAACAAGGA CCACTTGGTT ACAGCCTATA ACCATCTTTT TGAAACTAAG CGTTTTAAGG GTACTGAAAG TATAAGTAAA GTGTCTGAGC AAGTAAAAAA TGTGAAGCTT AATGAAGATA AACCCAAAGA AACCAAGTCT GAAGAGACCC TGGATGAGGG TCCACCAAAA TATACTAAAT CTGTTCTGAA AAAGGGAGAT AAAACCAACT TTCCCAAAAA GGGAGATGTT GTTCACTGCT GGTATACAGG AACACTACAA GATGGGACTG TTTTTGATAC TAATATTCAA ACAAGTGCAA AGAAGAAGAA AAATGCCAAG CCTTTAAGTT TTAAGGTCGG AGTAGGCAAA GTTATCAGAG GATGGGATGA AGCTCTCTTG ACTATGAGTA AAGGAGAAAA GGCTCGACTG GAGATTGAAC CAGAATGGGC TTACGGAAAG AAAGGACAGC CTGATGCCAA AATTCCACCA AATGCAAAAC TCACTTTTGA AGTGGAATTA GTGGATATTG ATTGA
< br>Transla tion Sequence: MAAAVPQRAW TVEQLRSEQL PKKDIIKFLQ EHGSDSFLAE HKLLGNIKNV AKTANKDHLV TAYNHLFETK RFKGTESISK VSEQVKNVKL NEDKPKETKS EETLDEGPPK YTKSVLKKGD KTNFPKKGDV VHCWYTGTLQ DGTVFDTNIQ TSAKKKKNAK PLSFKVGVGK VIRGWDEALL TMSKGEKARL EIEPEWAYGK KGQPDAKIPP NAKLTFEVEL VDID
Form/Format
Lyophilized
Preparation and Storage
Store the plasmid at -20 degree C.
OMIM
186947
3D Structure
ModBase 3D Structure for Q00688
Species
Human
Chromosome Location
14q21.2
OMIM Reference Number
186947
cDNA Size
675bp
Vector Description
This shuttle vector contains the complete ORF. It is inseted BamH I to Xho I. The gene insert contains multiple cloning sites which can be used to easily cut and transfer the gene and recombination site into your expression vector.
Vector
(puc19-derived cloning vector)
Preparation Before Usage
1. Centrifuge at 7000rpm for 1 minute. 2. Carefully open the vial and add 100ul of sterile water to dissolve the DNA. Each tube contains approximately 10ug of lyophilized plasmid.

Product Categories/Family for FKBP3 cdna clone

Heat Shock Proteins; Epigenomics (Transcription & Translation)

Other Notes

Small volumes of FKBP3 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FKBP3 purchase

MBS200525 is a cDNA clone targeting FKBP3.

Additional Details

NCBI/Uniprot data below describe general gene information for FKBP3. It may not necessarily be applicable to this product.

NCBI GI #
4503727
NCBI GeneID
2287
NCBI Accession #
NP_002004.1
UniProt Primary Accession #
Q00688
UniProt Related Accession #
Q00688
GenBank Nucleotide #
NM_002013.3
NCBI Official Full Name
peptidyl-prolyl cis-trans isomerase FKBP3
NCBI Official Synonym Full Names
FKBP prolyl isomerase 3
NCBI Official Symbol
FKBP3
NCBI Official Synonym Symbols
FKBP-3; FKBP25; PPIase; FKBP-25
UniProt Protein Name
Peptidyl-prolyl cis-trans isomerase FKBP3
UniProt Synonym Protein Names
25 kDa FK506-binding protein; 25 kDa FKBP; FKBP-25; FK506-binding protein 3; FKBP-3; Immunophilin FKBP25; Rapamycin-selective 25 kDa immunophilin; Rotamase
Protein Family
FK506-binding protein
UniProt Gene Name
FKBP3
UniProt Synonym Gene Names
FKBP25; PPIase FKBP3; 25 kDa FKBP; FKBP-25; FKBP-3
UniProt Entry Name
FKBP3_HUMAN
NCBI Protein Information
peptidyl-prolyl cis-trans isomerase FKBP3

NCBI Summary for FKBP3

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin. [provided by RefSeq, Sep 2008]
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UniProt Comments for FKBP3

FKBP3: FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins. Belongs to the FKBP-type PPIase family.

Protein type: EC 5.2.1.8; Isomerase

Chromosomal Location of Human Ortholog: 14q21.2

Cellular Component: endoplasmic reticulum membrane; nucleus

Molecular Function: protein binding; peptidyl-prolyl cis-trans isomerase activity; FK506 binding; receptor activity

Biological Process: protein peptidyl-prolyl isomerization
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Research Articles on FKBP3

1. Results demonstrate that FKBP25 is a novel microtubule-associated protein that engages both nucleic acids and microtubules, and that these interactions are controlled by carefully timed phosphorylation events to ensure proper cell division and genome segregation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with FKBP3 cdna clone

 Reference Product  PubMed Publications
 HDAC1 cdna clone  >1 publications with FKBP3 and HDAC1

Pathways associated with FKBP3 cdna clone

 Products by Pathway  Pathway Diagram
 Integrated Pancreatic Cancer Pathway antibodies  Integrated Pancreatic Cancer Pathway Diagram
 Signaling Events Mediated By HDAC Class I Pathway antibodies  Signaling Events Mediated By HDAC Class I Pathway Diagram

Diseases associated with FKBP3 cdna clone

 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >1 publications with FKBP3 and Immune System Diseases
 Liver Diseases Antibodies  >1 publications with FKBP3 and Liver Diseases
 Inflammation Antibodies  >1 publications with FKBP3 and Inflammation

Organs/Tissues associated with FKBP3 cdna clone

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4 publications with FKBP3 and Brain
 Liver Antibodies  >2 publications with FKBP3 and Liver
 Ovary Antibodies  >1 publications with FKBP3 and Ovary
 Eye Antibodies  >1 publications with FKBP3 and Eye
 Testis Antibodies  >1 publications with FKBP3 and Testis
 Heart Antibodies  >1 publications with FKBP3 and Heart
 Blood Antibodies  >1 publications with FKBP3 and Blood
 Muscle Antibodies  >1 publications with FKBP3 and Muscle
 Embryonic Tissue Antibodies  >1 publications with FKBP3 and Embryonic Tissue
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