Human FLT3 cDNA Clone Expression Plasmid – Cat# MBS1278881

FLT3 cDNA Clone – Fms-Related Tyrosine Kinase 3 (Human)

Name: FLT3 cDNA Clone; Fms-Related Tyrosine Kinase 3; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1278881
Price: 400 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1278881

MBS1278881 is a cDNA clone targeting FLT3. More details

$400 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

FLT3, cDNA Clone

Full Product Name

FLT3 cDNA Clone

Product Gene Name

FLT3 cdna clone

Sequence

ATGCCGGCGT TGGCGCGCGA CGGCGGCCAG CTGCCGCTGC TCGTTGTTTT TTCTGCAATG ATATTTGGGA CTATTACAAA TCAAGATCTG CCTGTGATCA AGTGTGTTTT AATCAATCAT AAGAACAATG ATTCATCAGT GGGGAAGTCA TCATCATATC CCATGGTATC AGAATCCCCG GAAGACCTCG GGTGTGCGTT GAGACCCCAG AGCTCAGGGA CAGTGTACGA AGCTGCCGCT GTGGAAGTGG ATGTATCTGC TTCCATCACA CTGCAAGTGC TGGTCGATGC CCCAGGGAAC ATTTCCTGTC TCTGGGTCTT TAAGCACAGC TCCCTGAATT GCCAGCCACA TTTTGATTTA CAAAACAGAG GAGTTGTTTC CATGGTCATT TTGAAAATGA CAGAAACCCA AGCTGGAGAA TACCTACTTT TTATTCAGAG TGAAGCTACC AATTACACAA TATTGTTTAC AGTGAGTATA AGAAATACCC TGCTTTACAC ATTAAGAAGA CCTTACTTTA GAAAAATGGA AAACCAGGAC GCCCTGGTCT GCATATCTGA GAGCGTTCCA GAGCCGATCG TGGAATGGGT GCTTTGCGAT TCACAGGGGG AAAGCTGTAA AGAAGAAAGT CCAGCTGTTG TTAAAAAGGA GGAAAAAGTG CTTCATGAAT TATTTGGGAC GGACATAAGG TGCTGTGCCA GAAATGAACT GGGCAGGGAA TGCACCAGGC TGTTCACAAT AGATCTAAAT CAAACTCCTC AGACCACATT GCCACAATTA TTTCTTAAAG TAGGGGAACC CTTATGGATA AGGTGCAAAG CTGTTCATGT GAACCATGGA TTCGGGCTCA CCTGGGAATT AGAAAACAAA GCACTCGAGG AGGGCAACTA CTTTGAGATG AGTACCTATT CAACAAACAG AACTATGATA CGGATTCTGT TTGCTTTTGT ATCATCAGTG GCAAGAAACG ACACCGGATA CTACACTTGT TCCTCTTCAA AGCATCCCAG TCAATCAGCT TTGGTTACCA TCGTAGAAAA GGGATTTATA AATGCTACCA ATTCAAGTGA AGATTATGAA ATTGACCAAT ATGAAGAGTT TTGTTTTTCT GTCAGGTTTA AAGCCTACCC ACAAATCAGA TGTACGTGGA CCTTCTCTCG AAAATCATTT CCTTGTGAGC AAAAGGGTCT TGATAACGGA TACAGCATAT CCAAGTTTTG CAATCATAAG CACCAGCCAG GAGAATATAT ATTCCATGCA GAAAATGATG ATGCCCAATT TACCAAAATG TTCACGCTGA ATATAAGAAG GAAACCTCAA GTGCTCGCAG AAGCATCGGC AAGTCAGGCG TCCTGTTTCT CGGATGGATA CCCATTACCA TCTTGGACCT GGAAGAAGTG TTCAGACAAG TCTCCCAACT GCACAGAAGA GATCACAGAA GGAGTCTGGA ATAGAAAGGC TAACAGAAAA GTGTTTGGAC AGTGGGTGTC GAGCAGTACT CTAAACATGA GTGAAGCCAT AAAAGGGTTC CTGGTCAAGT GCTGTGCATA CAATTCCCTT GGCACATCTT GTGAGACGAT CCTTTTAAAC TCTCCAGGCC CCTTCCCTTT CATCCAAGAC AACATCTCAT TCTATGCAAC AATTGGTGTT TGTCTCCTCT TCATTGTCGT TTTAACCCTG CTAATTTGTC ACAAGTACAA AAAGCAATTT AGGTATGAAA GCCAGCTACA GATGGTACAG GTGACCGGCT CCTCAGATAA TGAGTACTTC TACGTTGATT TCAGAGAATA A

Molecular Weight

108,378 Da

OMIM

136351

Vector

pENTR223.1 or pUC

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of FLT3 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for FLT3. It may not necessarily be applicable to this product.

NCBI GI #

23273564

NCBI GeneID

2322

NCBI Accession #

BC036028

UniProt Secondary Accession #

Q13414; A0AVG9; B7ZLT7; B7ZLT8; F5H0A0

UniProt Related Accession #

P36888

NCBI Official Full Name

Homo sapiens fms-related tyrosine kinase 3, mRNA

NCBI Official Synonym Full Names

fms related tyrosine kinase 3

NCBI Official Symbol

FLT3

NCBI Official Synonym Symbols

FLK2; STK1; CD135; FLK-2

UniProt Protein Name

Receptor-type tyrosine-protein kinase FLT3

UniProt Synonym Protein Names

FL cytokine receptor; Fetal liver kinase-2; FLK-2; Fms-like tyrosine kinase 3; FLT-3; Stem cell tyrosine kinase 1; STK-1; CD_antigen: CD135

Protein Family

Receptor-type tyrosine-protein kinase

UniProt Gene Name

FLT3

UniProt Synonym Gene Names

CD135; FLK2; STK1; FLK-2; FLT-3; STK-1

UniProt Entry Name

FLT3_HUMAN

NCBI Protein Information

receptor-type tyrosine-protein kinase FLT3

NCBI Summary for FLT3

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015]

UniProt Comments for FLT3

FLT3: a receptor tyrosine kinase of the PDGFR family that binds the FL cytokine. FLT3 -/- mice have an impaired developmental capacity of primitive hematopoietic progenitor cells of all lineages with the greatest impact on lymphopoietic precursors. Activating mutations found in one third of cases of acute myeloid leukemia (AML), as well as in acute lymphoblastic leukemia, acute promyelocytic leukemia and myelodysplastic syndrome. Inhibitors: Sutent and PKC412.

Protein type: Oncoprotein; EC 2.7.10.1; Membrane protein, integral; Protein kinase, TK; Kinase, protein; Protein kinase, tyrosine (receptor); TK group; PDGFR family

Chromosomal Location of Human Ortholog: 13q12

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; protein homodimerization activity; transmembrane receptor protein tyrosine kinase activity; vascular endothelial growth factor receptor activity

Biological Process: B cell differentiation; cytokine and chemokine mediated signaling pathway; hemopoiesis; leukocyte homeostasis; lymphocyte proliferation; myeloid progenitor cell differentiation; peptidyl-tyrosine phosphorylation; positive regulation of cell proliferation; positive regulation of MAP kinase activity; positive regulation of MAPKKK cascade; positive regulation of phosphoinositide 3-kinase activity; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of tyrosine phosphorylation of STAT protein; pro-B cell differentiation; protein amino acid autophosphorylation; regulation of apoptosis; transmembrane receptor protein tyrosine kinase signaling pathway

Disease: Leukemia, Acute Lymphoblastic

Research Articles on FLT3

1. Molecular docking studies suggest the involvement of Leu616, Asp698, Cys694 and Cys828 residues in binding of G-11 to FLT3. The ability of G-11 to cause selective cytotoxicity and induce differentiation in cancer cells could be clinically relevant

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with FLT3 cdna clone

Products by Pathway	Pathway Diagram
Acute Myeloid Leukemia Pathway antibodies	Acute Myeloid Leukemia Pathway Diagram
Acute Myeloid Leukemia Pathway antibodies	Acute Myeloid Leukemia Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Hematopoietic Cell Lineage Pathway antibodies	Hematopoietic Cell Lineage Pathway Diagram
Hematopoietic Cell Lineage Pathway antibodies	Hematopoietic Cell Lineage Pathway Diagram
Pathways In Cancer antibodies	Pathways In Cancer Diagram
Transcriptional Misregulation In Cancer Pathway antibodies	Transcriptional Misregulation In Cancer Pathway Diagram
Transcriptional Misregulation In Cancer Pathway antibodies	Transcriptional Misregulation In Cancer Pathway Diagram

Diseases associated with FLT3 cdna clone

Disease Name	Pubmed Publications
Neoplasms Antibodies	>1794 publications with FLT3 and Neoplasms
Leukemia, Myeloid, Acute Antibodies	>1496 publications with FLT3 and Leukemia, Myeloid, Acute
Bone Marrow Diseases Antibodies	>264 publications with FLT3 and Bone Marrow Diseases
Cell Transformation, Neoplastic Antibodies	>137 publications with FLT3 and Cell Transformation, Neoplastic
Leukemia, Promyelocytic, Acute Antibodies	>127 publications with FLT3 and Leukemia, Promyelocytic, Acute
Necrosis Antibodies	>113 publications with FLT3 and Necrosis
Neoplasms, Experimental Antibodies	>92 publications with FLT3 and Neoplasms, Experimental
Carcinoma Antibodies	>85 publications with FLT3 and Carcinoma
Inflammation Antibodies	>69 publications with FLT3 and Inflammation
Leukemia, Myelogenous, Chronic, BCR-ABL Positive Antibodies	>66 publications with FLT3 and Leukemia, Myelogenous, Chronic, BCR-ABL Positive

Organs/Tissues associated with FLT3 cdna clone

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>1624 publications with FLT3 and Blood
Bone Marrow Antibodies	>970 publications with FLT3 and Bone Marrow
Lung Antibodies	>78 publications with FLT3 and Lung
Thymus Antibodies	>66 publications with FLT3 and Thymus
Brain Antibodies	>58 publications with FLT3 and Brain
Kidney Antibodies	>36 publications with FLT3 and Kidney
Intestine Antibodies	>18 publications with FLT3 and Intestine
Testis Antibodies	>5 publications with FLT3 and Testis
Stomach Antibodies	>2 publications with FLT3 and Stomach
Bladder Antibodies	>2 publications with FLT3 and Bladder