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FMO4 cDNA Clone – Flavin Containing Monooxygenase 4 (Human)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1278118

MBS1278118 is a cDNA clone targeting FMO4. More details

$400 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
FMO4, cDNA Clone
Full Product Name
FMO4 cDNA Clone
Product Gene Name
FMO4 cdna clone
Sequence
atggccaaga aagttgcagt gattggagct ggtgtgagtg gcctctcctc catcaaatgc tgtgtggatg aggacctgga gcccacctgc tttgagagaa gtgatgacat tgggggatta tggaagttta ctgaatcttc caaagatggg atgaccaggg tctataagtc attagtgaca aatgtctgta aggaaatgtc atgttacagt gacttccctt tccacgaaga ttatcctaat ttcatgaacc atgaaaaatt ttgggactat ctccaagaat ttgctgagca ctttgacctc ctgaaataca ttcagtttaa gaccactgtg tgcagcataa cgaagcgtcc agacttctcc gaaactggtc agtgggatgt tgtcacagag acagagggca agcaaaatag agctgtcttt gatgctgtta tggtttgcac tggacatttc ctgaatcccc atttaccttt ggaagccttt cctggaattc ataagtttaa aggtcagatc ctgcatagtc aagagtacaa gatcccagaa ggctttcagg gcaaacgcgt cttggtgatt ggtcttggga acactggagg agacattgct gtggaactca gtcgaacggc agctcaggta cttctcagta ctagaactgg tacctgggtt cttgggcgct cttcagattg gggctatcct tataatatga tggttacaag aagatgctgt agttttattg cacaagttct gccttcacgt tttctaaact ggattcaaga aaggaagttg aataagagat ttaatcatga ggattatgga ttaagtatta ccaaagggaa aaaagcaaaa ttcattgtga atgatgagct gccaaactgt atcctctgtg gggcaatcac tatgaaaacc agcgtgattg aatttacaga aacctctgct gtctttgaag atgggacagt ggaagaaaac attgatgttg tgatcttcac tacaggatat acattttctt ttccattttt tgaagaacct cttaaaagcc tctgtacaaa gaagatattt ctatacaagc aagtctttcc cttaaaccta gagagagcga cattagccat catcggcctt atcggcctta aaggatccat cttatcaggc acagagctcc aagcacgatg ggtcacaaga gtattcaaag gactctgtaa gatacctcca tcccaaaaat tgatgatgga ggctactgaa aaggaacagc tcattaaaag gggagtgttt aaagacacca gcaaagacaa atttgactac attgcctaca tggatgatat cgctgcctgc ataggcacaa agcccagcat cccacttctg ttcctcaagg atcccagact agcttgggaa gttttctttg gaccatgtac tccttatcag taccgcctca tgggccctgg aaaatgggat ggagccagaa atgccatcct gacccagtgg gacagaacat tgaaaccttt aaaaactcga attgtccctg attcctccaa gcctgcctcc atgtcacatt atttaaaagc ctggggggca cctgtcctac ttgcctctct tctacttatc tgtaaatctt cacttttctt gaaattggtg agagataaac tacaggacag aatgtcccct tacctagtaa gtctttggcg aggatga
Molecular Weight
63,343 Da
OMIM
136131
Vector
pENTR223.1 or pUC
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of FMO4 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for FMO4. It may not necessarily be applicable to this product.

NCBI GI #
33877166
NCBI GeneID
2329
NCBI Accession #
BC002780
UniProt Secondary Accession #
Q53XR0
UniProt Related Accession #
P31512
NCBI Official Full Name
Homo sapiens flavin containing monooxygenase 4, mRNA
NCBI Official Synonym Full Names
flavin containing monooxygenase 4
NCBI Official Symbol
FMO4
NCBI Official Synonym Symbols
FMO2
UniProt Protein Name
Dimethylaniline monooxygenase [N-oxide-forming] 4
UniProt Synonym Protein Names
Dimethylaniline oxidase 4; Hepatic flavin-containing monooxygenase 4; FMO 4
Protein Family
Dimethylaniline monooxygenase
UniProt Gene Name
FMO4
UniProt Synonym Gene Names
FMO2; FMO 4
UniProt Entry Name
FMO4_HUMAN
NCBI Protein Information
dimethylaniline monooxygenase [N-oxide-forming] 4

NCBI Summary for FMO4

Metabolic N-oxidation of diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man. This results in a small subpopulation with reduced TMA N-oxidation capacity and causes fish odor syndrome (Trimethylaminuria). Three forms of the enzyme are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. [provided by RefSeq, Jan 2015]
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UniProt Comments for FMO4

FMO4: This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Belongs to the FMO family.

Protein type: Xenobiotic Metabolism - drug metabolism - cytochrome P450; Oxidoreductase; EC 1.14.13.8; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q24.3

Molecular Function: flavin-containing monooxygenase activity

Biological Process: drug metabolic process
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Research Articles on FMO4

1. Observational study of gene-disease association. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with FMO4 cdna clone

 Products by Pathway  Pathway Diagram
 Catalytic Cycle Of Mammalian FMOs Pathway antibodies  Catalytic Cycle Of Mammalian FMOs Pathway Diagram
 Drug Metabolism - Cytochrome P450 Pathway antibodies  Drug Metabolism - Cytochrome P450 Pathway Diagram
 Drug Metabolism - Cytochrome P450 Pathway antibodies  Drug Metabolism - Cytochrome P450 Pathway Diagram
 Metapathway Biotransformation antibodies  Metapathway Biotransformation Diagram

Diseases associated with FMO4 cdna clone

 Disease Name  Pubmed Publications
 Drug Toxicity Antibodies  >51 publications with FMO4 and Drug Toxicity
 Liver Diseases Antibodies  >22 publications with FMO4 and Liver Diseases
 Neoplasms Antibodies  >13 publications with FMO4 and Neoplasms
 Nervous System Diseases Antibodies  >9 publications with FMO4 and Nervous System Diseases
 Disease Models, Animal Antibodies  >9 publications with FMO4 and Disease Models, Animal
 Necrosis Antibodies  >7 publications with FMO4 and Necrosis
 Drug-Induced Liver Injury Antibodies  >7 publications with FMO4 and Drug-Induced Liver Injury
 Mental Disorders Antibodies  >5 publications with FMO4 and Mental Disorders
 Liver Neoplasms Antibodies  >5 publications with FMO4 and Liver Neoplasms
 Brain Diseases Antibodies  >5 publications with FMO4 and Brain Diseases

Organs/Tissues associated with FMO4 cdna clone

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >382 publications with FMO4 and Liver
 Lung Antibodies  >90 publications with FMO4 and Lung
 Kidney Antibodies  >72 publications with FMO4 and Kidney
 Brain Antibodies  >34 publications with FMO4 and Brain
 Intestine Antibodies  >16 publications with FMO4 and Intestine
 Muscle Antibodies  >6 publications with FMO4 and Muscle
 Embryonic Tissue Antibodies  >5 publications with FMO4 and Embryonic Tissue
 Skin Antibodies  >3 publications with FMO4 and Skin
 Nerve Antibodies  >3 publications with FMO4 and Nerve
 Testis Antibodies  >2 publications with FMO4 and Testis
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