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FRS3 cDNA Clone – Fibroblast Growth Factor Receptor Substrate 3 (Human)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1278673

MBS1278673 is a cDNA clone targeting FRS3. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
FRS3, cDNA Clone
Full Product Name
FRS3 cDNA Clone
Product Gene Name
FRS3 cdna clone
Sequence
atggggagct gctgcagctg cctgaacaga gacagcgttc cagacaacca ccccaccaag ttcaaggtga caaatgtgga tgatgagggg gtggagctgg gctctggggt gatggagctg acgcagagtg agctggtgct gcacctgcat cggcgtgagg ccgtccgctg gccttatctc tgcttgcggc gctatggcta cgactccaac ctcttctcct ttgagagtgg ccgccgatgt cagacaggcc agggaatatt tgcatttaag tgttcccggg ctgaggaaat cttcaacctc cttcaggatc tgatgcagtg caacagcatc aatgtgatgg aagagcctgt catcatcacc cgcaatagcc accccgctga gcttgacctc cctcgagccc cccagccacc caatgctcta ggctacactg tctccagctt ttccaatggc tgccctggag agggcccacg attctcagct ccccggcggc tctcgacaag cagcctgcgg cacccctcgc ttggggaaga gtccacccat gccctcattg ctcctgatga gcagtcccac acctatgtca acacaccggc cagtgaagat gaccaccgca ggggccgcca ctgcctgcag cccctgcctg agggtcaggc acccttcctc ccgcaggccc ggggacctga ccaacgggac ccacaggtgt tcttgcagcc aggccaggtg aagtttgtgt tgggcccgac ccctgctcgg cggcacatgg tgaagtgcca gggcctctgt cccagcctgc atgacccccc acaccacaat aataacaatg aggccccttc tgagtgtcca gcccagccca agtgcaccta cgagaacgtc accggggggc tgtggcgagg ggctggctgg agactgagcc cagaggagcc gggctggaat ggccttgccc accgccgggc cgccctgctg cactatgaga acctgccccc actgccccct gtgtgggaaa gccaagccca gcagctggga ggggaggctg gggatgatgg ggactcgagg gatgggctca caccctcttc caatggcttc cctgatggtg aggaggacga gaccccactg cagaagccca ccagcacccg ggccgccatc cgcagccacg gcagctttcc tgtgccactg acccgccgcc gcggctcccc aagggtcttc aactttgatt tccgccggcc ggggcccgag cccccaaggc agcttaacta catccaggtg gagctaaagg gctggggtgg agaccgccct aaggggcccc agaacccctc gagcccccaa gcccccatgc ccaccaccca ccctgcccga agctcagact cctacgccgt gattgacctc aaaaagaccg tggccatgtc caacctgcag agagctctgc cccgagacga tggcaccgcc aggaaaaccc ggcacaacag caccgacctg cctctgtag
Molecular Weight
54,462 Da
OMIM
607744
Vector
pENTR223.1 or pUC
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of FRS3 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for FRS3. It may not necessarily be applicable to this product.

NCBI GI #
14714909
NCBI GeneID
10817
NCBI Accession #
BC010611
UniProt Secondary Accession #
Q5T3D5
UniProt Related Accession #
O43559
NCBI Official Full Name
Homo sapiens fibroblast growth factor receptor substrate 3, mRNA
NCBI Official Synonym Full Names
fibroblast growth factor receptor substrate 3
NCBI Official Symbol
FRS3
NCBI Official Synonym Symbols
SNT2; FRS2B; SNT-2; FRS2beta; FRS2-beta
UniProt Protein Name
Fibroblast growth factor receptor substrate 3
UniProt Synonym Protein Names
FGFR-signaling adaptor SNT2; Suc1-associated neurotrophic factor target 2; SNT-2
Protein Family
Fibroblast growth factor receptor substrate
UniProt Gene Name
FRS3
UniProt Synonym Gene Names
FGFR substrate 3; SNT-2
UniProt Entry Name
FRS3_HUMAN
NCBI Protein Information
fibroblast growth factor receptor substrate 3

NCBI Summary for FRS3

This gene encodes a substrate for the fibroblast growth factor receptor. The encoded protein is found in the peripheral plasma membrane and links fibroblast growth factor receptor stimulation to activators of Ras. The encoded protein down-regulates extracellular regulated kinase 2 through direct binding. [provided by RefSeq, Jul 2013]
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UniProt Comments for FRS3

FRS3: Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 6p21.1

Cellular Component: plasma membrane

Molecular Function: fibroblast growth factor receptor binding; identical protein binding; protein binding; Ras guanyl-nucleotide exchange factor activity

Biological Process: fibroblast growth factor receptor signaling pathway; MAPKKK cascade; signal transduction
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Research Articles on FRS3

1. Mechanisms by which FRS2beta acts as a feedback inhibitor of EGFR family members and suggest a role for FRS2beta as a tumor suppressor.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with FRS3 cdna clone

 Products by Pathway  Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Downstream Signaling Of Activated FGFR Pathway antibodies  Downstream Signaling Of Activated FGFR Pathway Diagram
 FRS2-mediated Cascade Pathway antibodies  FRS2-mediated Cascade Pathway Diagram
 Neurotrophic Factor-mediated Trk Receptor Signaling Pathway antibodies  Neurotrophic Factor-mediated Trk Receptor Signaling Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By FGFR Pathway antibodies  Signaling By FGFR Pathway Diagram
 Signaling By FGFR In Disease Pathway antibodies  Signaling By FGFR In Disease Pathway Diagram

Diseases associated with FRS3 cdna clone

 Disease Name  Pubmed Publications
 Pregnancy Complications Antibodies  >1 publications with FRS3 and Pregnancy Complications
 Neural Tube Defects Antibodies  >1 publications with FRS3 and Neural Tube Defects

Organs/Tissues associated with FRS3 cdna clone

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4 publications with FRS3 and Brain
 Embryonic Tissue Antibodies  >3 publications with FRS3 and Embryonic Tissue
 Intestine Antibodies  >1 publications with FRS3 and Intestine
 Lung Antibodies  >1 publications with FRS3 and Lung
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