Human GIT2 cDNA Clone Expression Plasmid – Cat# MBS1270251

GIT2 cDNA Clone – G Protein-Coupled Receptor Kinase Interacting Arfgap 2 (Human)

Name: GIT2 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1270251
Price: 235 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1270251

MBS1270251 is a cDNA clone targeting GIT2. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GIT2, cDNA Clone

Full Product Name

GIT2 cDNA Clone

Product Gene Name

GIT2 cdna clone

Sequence

atgagtggaa gacgtaaagc taatccacag gataaagtac atcccaataa agcggaattc atcagagcca agtatcagat gttagcgttc gtccatcgct tgccctgccg ggatgacgat agtgtgactg ccaaagatct tagcaagcaa ctccattcga gcgtgagaac agggaatctt gaaacctgtt tgagactgtt atctttagga gcacaagcca acttctttca tcctgaaaaa ggaaacaccc cactccatgt tgcctccaaa gcagggcaga ttttacaggc tgaattattg gcagtatatg gagcagaccc aggcacacag gattctagtg ggaaaactcc cgttgattat gcaaggcaag gagggcacca tgagctggca gagcgcctcg tggaaataca gtatgagcta acggacagac tagccttcta tctctgtggc aggaaaccag atcacaaaaa tggacagcac tttataatac ctcaaatggc agacagcagc ctggatttgt ctgaattggc aaaagctgct aagaagaaac ttcaatctct aagtaatcat ttgtttgaag aacttgccat ggatgtgtac gatgaagttg acaggcgaga gacggatgca gtctggcttg ccacgcaaaa ccacagcgcc ctggtaaccg agacaacggt cgtccccttt cttccggtca atcctgagta ctcatcaaca cgaaatcagg gcagacagaa gttagctcgg ttcaacgccc atgagtttgc cacgctggtc attgacattc tcagtgacgc caagaggaga cagcagggca gttctctctc gggttcaaaa gacaatgtgg agctcatact gaaaaccatc aataaccagc acagcgttga gagtcaagac aacgatcagc ccgactatga cagcgtggca tcagacgaag acacagattt ggaaaccact gcaagcaaaa caaaccggca gaagagccta gattcagatt tatcagatgg accagtcact gtacaggaat ttatggaggt caaaaacgct ctagtggctt ctgaggccaa gatacagcag ctaatgaagg catccaggct ggagaagcag aacagcacac ctgagagtga ctacgacaac actcccaacg acatggagcc agatggcatg gggtcaagcc gaaagggacg gcaaagaagt atggtgtggc caggggatgg cttggtacca gacacagcag aaccccatgt ggccccaagc cccactctcc ctagcaccga agatgtcatc aggaagactg aacagatcac caaaaacata caggagctct taagagcagc ccaagaaaat aaacatgaca gttatattcc ctgctcagag aggatacacg tagctgttac agaaatggca gcattattcc ccaaaaaacc caagtctgat atggtgagga cttcccttcg tttactgacg tccagtgcct accgactgca gtcagagtgc aagaagaccc tcccagggga ccccggctca cccacagacg ttcagctggt cacgcagcag gtcatccagt gtgcgtacga catcgccaag gctgccaagc agctggttac catcaccacc aaagagaaca acaactga

Molecular Weight

70,183 Da

OMIM

608564

Vector

pENTR223.1

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of GIT2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GIT2. It may not necessarily be applicable to this product.

NCBI GI #

40226310

NCBI GeneID

9815

NCBI Accession #

BC014223

UniProt Secondary Accession #

Q86U59; Q96CI2; Q9BV91; Q9Y5V2

UniProt Related Accession #

Q14161

NCBI Official Full Name

Homo sapiens G protein-coupled receptor kinase interacting ArfGAP 2, mRNA

NCBI Official Synonym Full Names

GIT ArfGAP 2

NCBI Official Symbol

GIT2

NCBI Official Synonym Symbols

PKL; CAT2; CAT-2

UniProt Protein Name

ARF GTPase-activating protein GIT2

UniProt Synonym Protein Names

Cool-interacting tyrosine-phosphorylated protein 2; CAT-2; CAT2; G protein-coupled receptor kinase-interactor 2; GRK-interacting protein 2

Protein Family

ARF GTPase-activating protein

UniProt Gene Name

GIT2

UniProt Synonym Gene Names

KIAA0148; ARF GAP GIT2; CAT-2; CAT2

UniProt Entry Name

GIT2_HUMAN

NCBI Protein Information

ARF GTPase-activating protein GIT2

NCBI Summary for GIT2

This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding. [provided by RefSeq, Sep 2008]

UniProt Comments for GIT2

GIT2: possesses ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. Interacts with G protein-coupled receptor kinases. Associates with paxillin. Also interacts with PIX exchange factors. Regulates Golgi and actin cytoskeletal organization. Important in integrin-mediated cell adhesion. Ten alternatively spliced isoforms have been described and additional isoforms seem to exist. Contains 1 Arf-GAP domain and 3 ANK repeats.

Protein type: GAPs, ARF; Motility/polarity/chemotaxis; GAPs

Chromosomal Location of Human Ortholog: 12q24.1

Cellular Component: focal adhesion; nucleoplasm

Molecular Function: protein binding

Biological Process: regulation of G-protein coupled receptor protein signaling pathway

Research Articles on GIT2

1. GIT2 plays an important role in MRE11/ATM/H2AX-mediated DNA damage responses.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with GIT2 cdna clone

Products by Pathway	Pathway Diagram
Endocytosis Pathway antibodies	Endocytosis Pathway Diagram
Endocytosis Pathway antibodies	Endocytosis Pathway Diagram
Integrin-mediated Cell Adhesion Pathway antibodies	Integrin-mediated Cell Adhesion Pathway Diagram
Signaling Events Mediated By Focal Adhesion Kinase Pathway antibodies	Signaling Events Mediated By Focal Adhesion Kinase Pathway Diagram

Diseases associated with GIT2 cdna clone

Disease Name	Pubmed Publications
Neoplasms Antibodies	>3 publications with GIT2 and Neoplasms
Pancreatic Neoplasms Antibodies	>1 publications with GIT2 and Pancreatic Neoplasms
Learning Disorders Antibodies	>1 publications with GIT2 and Learning Disorders
Inflammation Antibodies	>1 publications with GIT2 and Inflammation