Human GRM3 cDNA Clone Expression Plasmid – Cat# MBS1265725

GRM3 cDNA Clone – Glutamate Receptor, Metabotropic 3 (Human)

Name: GRM3 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1265725
Price: 980 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1265725

MBS1265725 is a cDNA clone targeting GRM3. More details

$980 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GRM3, cDNA Clone

Full Product Name

GRM3 cDNA Clone

Product Gene Name

GRM3 cdna clone

Sequence

atgaagatgt tgacaagact gcaagttctt accttagctt tgttttcaaa gggattttta ctctctttag gggaccataa ctttctaagg agagagatta aaatagaagg tgaccttgtt ttagggggcc tgtttcctat taacgaaaaa ggcactggaa ctgaagaatg tgggcgaatc aatgaagacc gagggattca acgcctggaa gccatgttgt ttgctattga tgaaatcaac aaagatgatt acttgctacc aggagtgaag ttgggtgttc acatttttga tacatgttca agggatacct atgcattgga gcaatcactg gagtttgtca gggcatcttt gacaaaagtg gatgaagctg agtatatgtg tcctgatgga tcctatgcca ttcaagaaaa catcccactt ctcattgcag gggtcattgg tggctcttat agcagtgttt ccatacaggt ggcaaacctg ctgcggctct tccagatccc tcagatcagc tacgcatcca ccagcgccaa actcagtgat aagtcgcgct atgattactt tgccaggacc gtgccccccg acttctacca ggccaaagcc atggctgaga tcttgcgctt cttcaactgg acctacgtgt ccacagtagc ctccgagggt gattacgggg agacagggat cgaggccttc gagcaggaag cccgcctgcg caacatctgc atcgctacgg cggagaaggt gggccgctcc aacatccgca agtcctacga cagcgtgatc cgagaactgt tgcagaagcc caacgcgcgc gtcgtggtcc tcttcatgcg cagcgacgac tcgcgggagc tcattgcagc cgccagccgc gccaatgcct ccttcacctg ggtggccagc gacggctggg gcgcgcagga gagcatcatc aagggcagcg agcatgtggc ctacggcgcc atcaccctgg agctggcctc ccagcctgtc cgccagttcg accgctactt ccagagcctc aacccctaca acaaccaccg caacccctgg ttccgggact tctgggagca aaagtttcag tgcagcctcc agaacaaacg caaccacagg cgcgtctgcg acaagcacct ggccatcgac agcagcaact acgagcaaga gtccaagatc atgtttgtgg tgaacgcggt gtatgccatg gcccacgctt tgcacaaaat gcagcgcacc ctctgtccca acactaccaa gctttgtgat gctatgaaga tcctggatgg gaagaagttg tacaaggatt acttgctgaa aatcaacttc acggctccat tcaacccaaa taaagatgca gatagcatag tcaagtttga cacttttgga gatggaatgg ggcgatacaa cgtgttcaat ttccaaaatg taggtggaaa gtattcctac ttgaaagttg gtcactgggc agaaacctta tcgctagatg tcaactctat ccactggtcc cggaactcag tccccacttc ccagtgcagc gacccctgtg cccccaatga aatgaagaat atgcaaccag gggatgtctg ctgctggatt tgcatcccct gtgaacccta cgaatacctg gctgatgagt ttacctgtat ggattgtggg tctggacagt ggcccactgc agacctaact ggatgctatg accttcctga ggactacatc aggtgggaag acgcctgggc cattggccca gtcaccattg cctgtctggg ttttatgtgt acatgcatgg ttgtaactgt ttttatcaag cacaacaaca cacccttggt caaagcatcg ggccgagaac tctgctacat cttattgttt ggggttggcc tgtcatactg catgacattc ttcttcattg ccaagccatc accagtcatc tgtgcattgc gccgactcgg gctggggagt tccttcgcta tctgttactc agccctgctg accaagacaa actgcattgc ccgcatcttc gatggggtca agaatggcgc tcagaggcca aaattcatca gccccagttc tcaggttttc atctgcctgg gtctgatcct ggtgcaaatt gtgatggtgt ctgtgtggct catcctggag gccccaggca ccaggaggta tacccttgca gagaagcggg aaacagtcat cctaaaatgc aatgtcaaag attccagcat gttgatctct cttacctacg atgtgatcct ggtgatctta tgcactgtgt acgccttcaa aacgcggaag tgcccagaaa atttcaacga agctaagttc ataggtttta ccatgtacac cacgtgcatc atctggttgg ccttcctccc tatattttat gtgacatcaa gtgactacag agtgcagacg acaaccatgt gcatctctgt cagcctgagt ggctttgtgg tcttgggctg tttgtttgca cccaaggttc acatcatcct gtttcaaccc cagaagaatg ttgtcacaca cagactgcac ctcaacaggt tcagtgtcag tggaactggg accacatact ctcagtcctc tgcaagcacg tatgtgccaa cggtgtgcaa tgggcgggaa gtcctcgact ccaccacctc atctctgtga

Molecular Weight

60,749 Da

OMIM

601115

Vector

Please Inquire

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of GRM3 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GRM3. It may not necessarily be applicable to this product.

NCBI GI #

27552882

NCBI GeneID

2913

NCBI Accession #

BC041407

UniProt Secondary Accession #

Q2PNZ6; Q75MV4; Q75N17; Q86YG6; Q8TBH9

UniProt Related Accession #

Q14832

NCBI Official Full Name

Homo sapiens glutamate receptor, metabotropic 3, mRNA

NCBI Official Synonym Full Names

glutamate metabotropic receptor 3

NCBI Official Symbol

GRM3

NCBI Official Synonym Symbols

GLUR3; mGlu3; GPRC1C; MGLUR3

UniProt Protein Name

Metabotropic glutamate receptor 3

Protein Family

Metabotropic glutamate receptor

UniProt Gene Name

GRM3

UniProt Synonym Gene Names

GPRC1C; MGLUR3; mGluR3

UniProt Entry Name

GRM3_HUMAN

NCBI Protein Information

metabotropic glutamate receptor 3

NCBI Summary for GRM3

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Jul 2008]

UniProt Comments for GRM3

mGluR3: metabotropic glutamate receptor 3, a G-protein coupled receptor for glutamate. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity.

Protein type: GPCR, family 3; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 7q21.1-q21.2

Cellular Component: integral to plasma membrane; plasma membrane; presynaptic membrane

Molecular Function: G-protein coupled receptor activity; glutamate receptor activity

Biological Process: metabotropic glutamate receptor, adenylate cyclase inhibiting pathway; negative regulation of adenylate cyclase activity; regulation of synaptic transmission, glutamatergic; synaptic transmission

Research Articles on GRM3

1. Significant association was found between rs12704290 in GRM3 gene and schizophrenia(SCZ). A three-SNP LD spanning GRM3Delta4 splice site was significantly associated with SCZ. Interaction between the LD block and cognitive function was found in SCZ patients.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with GRM3 cdna clone

Products by Pathway	Pathway Diagram
Class C/3 (Metabotropic Glutamate/pheromone Receptors) Pathway antibodies	Class C/3 (Metabotropic Glutamate/pheromone Receptors) Pathway Diagram
Cocaine Addiction Pathway antibodies	Cocaine Addiction Pathway Diagram
Cocaine Addiction Pathway antibodies	Cocaine Addiction Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
GPCRs, Class C Metabotropic Glutamate, Pheromone Pathway antibodies	GPCRs, Class C Metabotropic Glutamate, Pheromone Pathway Diagram
Glutamatergic Synapse Pathway antibodies	Glutamatergic Synapse Pathway Diagram
Glutamatergic Synapse Pathway antibodies	Glutamatergic Synapse Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram

Diseases associated with GRM3 cdna clone

Disease Name	Pubmed Publications
Schizophrenia Antibodies	>50 publications with GRM3 and Schizophrenia
Cognition Disorders Antibodies	>10 publications with GRM3 and Cognition Disorders
Memory Disorders Antibodies	>5 publications with GRM3 and Memory Disorders
Melanoma Antibodies	>3 publications with GRM3 and Melanoma
Brain Diseases Antibodies	>2 publications with GRM3 and Brain Diseases
Neurobehavioral Manifestations Antibodies	>2 publications with GRM3 and Neurobehavioral Manifestations
Learning Disorders Antibodies	>2 publications with GRM3 and Learning Disorders
Growth Disorders Antibodies	>2 publications with GRM3 and Growth Disorders
Alcoholism Antibodies	>2 publications with GRM3 and Alcoholism
Poisoning Antibodies	>1 publications with GRM3 and Poisoning

Organs/Tissues associated with GRM3 cdna clone

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>35 publications with GRM3 and Brain
Vascular Antibodies	>2 publications with GRM3 and Vascular
Kidney Antibodies	>1 publications with GRM3 and Kidney