Human HEPH cDNA Clone Expression Plasmid – Cat# MBS1274346

HEPH cDNA Clone – Hephaestin (Human)

Name: HEPH cDNA Clone; Hephaestin; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1274346
Price: 1445 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1274346

MBS1274346 is a cDNA clone targeting HEPH. More details

$1445 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

HEPH, cDNA Clone

Full Product Name

HEPH cDNA Clone

Product Gene Name

HEPH cdna clone

Sequence

atggagtcag gccacctcct ctgggctctg ctgttcatgc agtccttgtg gcctcaactg actgatggag ccactcgagt ctactacctg ggcatccggg atgtgcagtg gaactatgct cccaagggaa gaaatgtcat cacgaaccag cctctggaca gtgacatagt ggcttccagc ttcttaaagt ctgacaagaa ccggataggg ggaacctaca agaagaccat ctataaagaa tacaaggatg actcatacac agatgaagtg gcccagcctg cctggttggg cttcctgggg ccagtgttgc aggctgaagt gggggatgtc attcttattc acctgaagaa ttttgccact cgtccctata ccatccaccc tcatggtgtc ttctacgaga aggactctga aggttcccta tacccagatg gctcctctgg gccactgaaa gctgatgact ctgttccccc ggggggcagc catatctaca actggaccat tccagaaggc catgcaccca ccgatgctga cccagcgtgc ctcacctgga tctaccattc tcatgtagat gctccacgag acattgcaac tggcctaatt gggcctctca tcacctgtaa aagaggagcc ctggatggga actcccctcc tcaacgccag gatgtagacc atgatttctt cctcctcttc agtgtggtag atgagaacct cagctggcat ctcaatgaga acattgccac ttactgctca gatcctgctt cagtggacaa agaagatgag acatttcagg agagcaatag gatgcatgca atcaatggct ttgtttttgg gaatttacct gagctgaaca tgtgtgcaca gaaacgtgtg gcctggcact tgtttggcat gggcaatgaa attgatgtcc acacagcatt tttccatgga cagatgctga ctacccgtgg acaccacact gatgtggcta acatctttcc agccaccttt gtgactgctg agatggtgcc ctgggaacct ggtacctggt taattagctg ccaagtgaac agtcactttc gagatggcat gcaggcactc tacaaggtca agtcttgctc catggcccct cctgtggacc tgctcacagg caaagttcga cagtacttca ttgaggccca tgagattcaa tgggactatg gcccgatggg gcatgatggg agtactggga agaatttgag agagccaggc agtatctcag ataagttttt ccagaagagc tccagccgaa ttgggggcac ttactggaaa gtgcgatatg aagcctttca agatgagaca ttccaagaga agatgcattt ggaggaagat aggcatcttg gaatcctggg gccagtgatc cgggctgagg tgggtgacac cattcaggtg gtcttctaca accgtgcctc ccagccattc agcatgcagc cccatggggt cttttatgag aaagactatg aaggcactgt gtacaatgat ggctcatctt accctggctt ggttgccaag ccctttgaga aagtaacata ccgctggaca gtcccccctc atgccggtcc cactgctcag gatcctgctt gtctcacttg gatgtacttc tctgctgcag atcccataag agacacaaat tctggcctgg tgggcccgct gctggtgtgc agggctggtg ccttgggtgc agatggcaag cagaaagggg tggataaaga attctttctt ctcttcactg tgttggatga gaacaagagc tggtacagca atgccaatca agcagctgct atgttggatt tccgactgct ttcagaggat attgagggct tccaagactc caatcggatg catgccatta atgggtttct gttctctaac ctgcccaggc tggacatgtg caagggtgac acagtggcct ggcacctgct cggcctgggc acagagactg atgtgcatgg agtcatgttc cagggcaaca ctgtgcagct tcagggcatg aggaagggtg cagctatgct ctttcctcat acctttgtca tggccatcat gcagcctgac aaccttggga catttgagat ttattgccag gcaggcagcc atcgagaagc agggatgagg gcaatctata atgtctccca gtgtcctggc caccaagcca cccctcgcca acgctaccaa gctgcaagaa tctactatat catggcagaa gaagtagagt gggactattg ccctgaccgg agctgggaac gggaatggca caaccagtct gagaaggaca gttatggtta cattttcctg agcaacaagg atgggctcct gggttccaga tacaagaaag ctgtattcag ggaatacact gatggtacat tcaggatccc tcggccaagg actggaccag aagaacactt gggaatcttg ggtccactta tcaaaggtga agttggtgat atcctgactg tggtattcaa gaataatgcc agccgcccct actctgtgca tgctcatgga gtgctagaat ctactactgt ctggccactg gctgctgagc ctggtgaggt ggtcacttat cagtggaaca tcccagagag gtctggccct gggcccaatg actctgcttg tgtttcctgg atctattatt ctgcagtgga tcccatcaag gacatgtata gtggcctggt ggggcccttg gctatctgcc aaaagggcat cctggagccc catggaggac ggagtgacat ggatcgggaa tttgcattgt tgttcttgat ttttgatgaa aataagtctt ggtatttgga ggaaaatgtg gcaacccatg ggtcccagga tccaggcagt attaacctac aggatgaaac tttcttggag agcaataaaa tgcatgcaat caatgggaaa ctctatgcca accttagggg tcttaccatg taccaaggag aacgagtggc ctggtacatg ctggccatgg gccaagatgt ggatctacac accatccact ttcatgcaga gagcttcctc tatcggaatg gcgagaacta ccgggcagat gtggtggatc tgttcccagg gacttttgag gttgtggaga tggtggccag caaccctggg acatggctga tgcactgcca tgtgactgac catgtccatg ctggcatgga gaccctcttc actgtttttt ctcgaacaga acacttaagc cctctcaccg tcatcaccaa agagactgaa aaagcagtgc cccccagaga cattgaagaa ggcaatgtga agatgctggg catgcagatc cccataaaga atgttgagat gctggcctct gttttggttg ccattagtgt cacccttctg ctcgttgttc tggctcttgg tggagtggtt tggtaccaac atcgacagag aaagctacga cgcaatagga ggtccatcct ggatgacagc ttcaagcttc tgtctttcaa acagtaa

Molecular Weight

100,624 Da

OMIM

300167

Vector

Please Inquire

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of HEPH cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for HEPH. It may not necessarily be applicable to this product.

NCBI GI #

15079444

NCBI GeneID

9843

NCBI Accession #

BC011561

UniProt Secondary Accession #

O75180; Q6UW45; Q9C058; B1AJX8; D3DVT7; E9PHN8

UniProt Related Accession #

Q9BQS7

NCBI Official Full Name

Homo sapiens hephaestin, mRNA

NCBI Official Synonym Full Names

hephaestin

NCBI Official Symbol

HEPH

NCBI Official Synonym Symbols

CPL

UniProt Protein Name

Hephaestin

Protein Family

Hephaestin

UniProt Gene Name

HEPH

UniProt Synonym Gene Names

KIAA0698

UniProt Entry Name

HEPH_HUMAN

NCBI Protein Information

hephaestin

NCBI Summary for HEPH

This gene encodes a member of the multicopper oxidase protein family. The encoded protein is involved in the transport of dietary iron from epithelial cells of the intestinal lumen into the circulatory system, and may be involved in copper transport and homeostasis. In mouse, defects in this gene can lead to severe microcytic anemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

UniProt Comments for HEPH

HEPH: May function as a ferroxidase for ferrous (II) to ferric ion (III) conversion and may be involved in copper transport and homeostasis. Implicated in iron homeostasis and may mediate iron efflux associated to ferroportin 1. Belongs to the multicopper oxidase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Oxidoreductase; Membrane protein, integral; EC 1.-.-.-

Chromosomal Location of Human Ortholog: Xq11-q12

Cellular Component: basolateral plasma membrane; intracellular; plasma membrane

Molecular Function: copper ion binding; ferrous iron binding; ferroxidase activity

Biological Process: cellular iron ion homeostasis; iron ion transport

Research Articles on HEPH

1. This review describes function of hephaestin as ferroxidase is essential for iron binding to apotransferrin in the lamina propria of the intestinal mucosa, a process that is important for further transport of iron to the liver by the portal vein.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with HEPH cdna clone

Products by Pathway	Pathway Diagram
Iron Uptake And Transport Pathway antibodies	Iron Uptake And Transport Pathway Diagram
Metal Ion SLC Transporters Pathway antibodies	Metal Ion SLC Transporters Pathway Diagram
Mineral Absorption Pathway antibodies	Mineral Absorption Pathway Diagram
Mineral Absorption Pathway antibodies	Mineral Absorption Pathway Diagram
SLC-mediated Transmembrane Transport Pathway antibodies	SLC-mediated Transmembrane Transport Pathway Diagram
Transmembrane Transport Of Small Molecules Pathway antibodies	Transmembrane Transport Of Small Molecules Pathway Diagram
Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway antibodies	Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway Diagram

Diseases associated with HEPH cdna clone

Disease Name	Pubmed Publications
Disease Models, Animal Antibodies	>11 publications with HEPH and Disease Models, Animal
Brain Diseases Antibodies	>7 publications with HEPH and Brain Diseases
Nervous System Diseases Antibodies	>6 publications with HEPH and Nervous System Diseases
Liver Diseases Antibodies	>6 publications with HEPH and Liver Diseases
Carcinoma Antibodies	>4 publications with HEPH and Carcinoma
Neoplasms Antibodies	>3 publications with HEPH and Neoplasms
Cardiovascular Diseases Antibodies	>3 publications with HEPH and Cardiovascular Diseases
Gastrointestinal Diseases Antibodies	>3 publications with HEPH and Gastrointestinal Diseases
Drug Toxicity Antibodies	>3 publications with HEPH and Drug Toxicity
Heart Diseases Antibodies	>2 publications with HEPH and Heart Diseases

Organs/Tissues associated with HEPH cdna clone

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>30 publications with HEPH and Liver
Eye Antibodies	>6 publications with HEPH and Eye
Muscle Antibodies	>5 publications with HEPH and Muscle
Heart Antibodies	>4 publications with HEPH and Heart
Spleen Antibodies	>4 publications with HEPH and Spleen
Embryonic Tissue Antibodies	>3 publications with HEPH and Embryonic Tissue
Stomach Antibodies	>2 publications with HEPH and Stomach
Bone Antibodies	>1 publications with HEPH and Bone
Pancreas Antibodies	>1 publications with HEPH and Pancreas
Bone Marrow Antibodies	>1 publications with HEPH and Bone Marrow