Human HEXA cDNA Clone Expression Plasmid – Cat# MBS1265985

HEXA cDNA Clone – Hexosaminidase A (Alpha Polypeptide) (Human)

Name: HEXA cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1265985
Price: 400 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1265985

MBS1265985 is a cDNA clone targeting HEXA. More details

$400 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

HEXA, cDNA Clone

Full Product Name

HEXA cDNA Clone

Product Gene Name

HEXA cdna clone

Sequence

atgacaagtt ccaggctttg gttttcgctg ctgctggcgg cagcgttcgc aggacgggcg acggccctct ggccctggcc tcagaacttc caaacctccg accagcgcta cgtcctttac ccgaacaact ttcaattcca gtacgatgtc agctcggccg cgcagcccgg ctgctcagtc ctcgacgagg ccttccagcg ctatcgtgac ctgcttttcg gttccgggtc ttggccccgt ccttacctca cagggaaacg gcatacactg gagaagaatg tgttggttgt ctctgtagtc acacctggat gtaaccagct tcctactttg gagtcagtgg agaattatac cctgaccata aatgatgacc agtgtttact cctctctgag actgtctggg gagctctccg aggtctggag acttttagcc agcttgtttg gaaatctgct gagggcacat tctttatcaa caagactgag attgaggact ttccccgctt tcctcaccgg ggcttgctgt tggatacatc tcgccattac ctgccactct ctagcatcct ggacactctg gatgtcatgg cgtacaataa attgaacgtg ttccactggc atctggtaga tgatccttcc ttcccatatg agagcttcac ttttccagag ctcatgagaa aggggtccta caaccctgtc acccacatct acacagcaca ggatgtgaag gaggtcattg aatacgcacg gctccggggt atccgtgtgc ttgcagagtt tgacactcct ggccacactt tgtcctgggg accaggtatc cctggattac tgactccttg ctactctggg tctgagccct ctggcacctt tggaccagtg aatcccagtc tcaataatac ctatgagttc atgagcacat tcttcttaga agtcagctct gtcttcccag atttttatct tcatcttgga ggagatgagg ttgatttcac ctgctggaag tccaacccag agatccagga ctttatgagg aagaaaggct tcggtgagga cttcaagcag ctggagtcct tctacatcca gacgctgctg gacatcgtct cttcttatgg caagggctat gtggtgtggc aggaggtgtt tgataataaa gtaaagattc agccagacac aatcatacag gtgtggcgag aggatattcc agtgaactat atgaaggagc tggaactggt caccaaggcc ggcttccggg cccttctctc tgccccctgg tacctgaacc gtatatccta tggccctgac tggaaggatt tctacgtagt ggaacccctg gcatttgaag gtacccctga gcagaaggct ctggtgattg gtggagaggc ttgtatgtgg ggagaatatg tggacaacac aaacctggtc cccaggctct ggcccagagc aggggctgtt gccgaaaggc tgtggagcaa caagttgaca tctgacctga catttgccta tgaacgtttg tcacacttcc gctgtgagtt gctgaggcga ggtgtccagg cccaacccct caatgtaggc ttctgtgagc aggagtttga acagacctga

Molecular Weight

19,326 Da

OMIM

272800

Vector

pUC

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of HEXA cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for HEXA. It may not necessarily be applicable to this product.

NCBI GI #

39644935

NCBI GeneID

3073

NCBI Accession #

BC018927

UniProt Secondary Accession #

Q53HS8; Q6AI32; B4DKE7; E7ENH7

UniProt Related Accession #

P06865

NCBI Official Full Name

Homo sapiens hexosaminidase A (alpha polypeptide), mRNA

NCBI Official Synonym Full Names

hexosaminidase subunit alpha

NCBI Official Symbol

HEXA

NCBI Official Synonym Symbols

TSD

UniProt Protein Name

Beta-hexosaminidase subunit alpha

UniProt Synonym Protein Names

Beta-N-acetylhexosaminidase subunit alpha; Hexosaminidase subunit A; N-acetyl-beta-glucosaminidase subunit alpha

Protein Family

Beta-hexosaminidase

UniProt Gene Name

HEXA

UniProt Synonym Gene Names

Hexosaminidase subunit A

UniProt Entry Name

HEXA_HUMAN

NCBI Protein Information

beta-hexosaminidase subunit alpha

NCBI Summary for HEXA

This gene encodes a member of the glycosyl hydrolase 20 family of proteins. The encoded preproprotein is proteolytically processed to generate the alpha subunit of the lysosomal enzyme beta-hexosaminidase. This enzyme, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Mutations in this gene lead to an accumulation of GM2 ganglioside in neurons, the underlying cause of neurodegenerative disorders termed the GM2 gangliosidoses, including Tay-Sachs disease (GM2-gangliosidosis type I). Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]

UniProt Comments for HEXA

HEXA: Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues. The form B is active against certain oligosaccharides. The form S has no measurable activity. Defects in HEXA are the cause of GM2-gangliosidosis type 1 (GM2G1); also known as Tay-Sachs disease. GM2- gangliosidosis is an autosomal recessive lysosomal storage disease marked by the accumulation of GM2 gangliosides in the neuronal cells. GM2G1 is characterized by GM2 gangliosides accumulation in the absence of HEXA activity, leading to neurodegeneration and, in the infantile form, death in early childhood. GM2G1 has an increased incidence among Ashkenazi Jews and French Canadians in eastern Quebec. It exists in several forms: infantile (most common and most severe), juvenile and adult (late onset). Belongs to the glycosyl hydrolase 20 family.

Protein type: Glycan Metabolism - glycosphingolipid biosynthesis - globo series; Carbohydrate Metabolism - amino sugar and nucleotide sugar; Hydrolase; Glycan Metabolism - glycosaminoglycan degradation; EC 3.2.1.52; Glycan Metabolism - other glycan degradation; Glycan Metabolism - glycosphingolipid biosynthesis - ganglio series

Chromosomal Location of Human Ortholog: 15q24.1

Cellular Component: azurophil granule; lysosomal lumen; membrane

Molecular Function: acetylglucosaminyltransferase activity; beta-N-acetylhexosaminidase activity; protein heterodimerization activity

Biological Process: chondroitin sulfate catabolic process; glycosaminoglycan biosynthetic process; glycosphingolipid metabolic process; hyaluronan catabolic process; keratan sulfate catabolic process

Disease: Tay-sachs Disease

Research Articles on HEXA

1. reports a new missense mutation in the HEXA gene in two German siblings with late-onset Tay-Sachs disease and prominent psychiatric symptoms

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with HEXA cdna clone

Products by Pathway	Pathway Diagram
Amino Sugar And Nucleotide Sugar Metabolism Pathway antibodies	Amino Sugar And Nucleotide Sugar Metabolism Pathway Diagram
Amino Sugar And Nucleotide Sugar Metabolism Pathway antibodies	Amino Sugar And Nucleotide Sugar Metabolism Pathway Diagram
CS/DS Degradation Pathway antibodies	CS/DS Degradation Pathway Diagram
Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway antibodies	Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
Glycosaminoglycan Degradation Pathway antibodies	Glycosaminoglycan Degradation Pathway Diagram
Glycosaminoglycan Degradation Pathway antibodies	Glycosaminoglycan Degradation Pathway Diagram
Glycosaminoglycan Metabolism Pathway antibodies	Glycosaminoglycan Metabolism Pathway Diagram
Glycosphingolipid Biosynthesis - Ganglio Series Pathway antibodies	Glycosphingolipid Biosynthesis - Ganglio Series Pathway Diagram
Glycosphingolipid Biosynthesis - Ganglio Series Pathway antibodies	Glycosphingolipid Biosynthesis - Ganglio Series Pathway Diagram

Diseases associated with HEXA cdna clone

Disease Name	Pubmed Publications
Tay-Sachs Disease Antibodies	>126 publications with HEXA and Tay-Sachs Disease
Drug Toxicity Antibodies	>88 publications with HEXA and Drug Toxicity
Neoplasms Antibodies	>70 publications with HEXA and Neoplasms
Hepatitis Antibodies	>54 publications with HEXA and Hepatitis
Liver Diseases Antibodies	>37 publications with HEXA and Liver Diseases
Carcinoma Antibodies	>32 publications with HEXA and Carcinoma
Inflammation Antibodies	>30 publications with HEXA and Inflammation
Necrosis Antibodies	>27 publications with HEXA and Necrosis
Poisoning Antibodies	>21 publications with HEXA and Poisoning
Death Antibodies	>21 publications with HEXA and Death

Organs/Tissues associated with HEXA cdna clone

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>297 publications with HEXA and Blood
Liver Antibodies	>147 publications with HEXA and Liver
Brain Antibodies	>114 publications with HEXA and Brain
Kidney Antibodies	>68 publications with HEXA and Kidney
Lung Antibodies	>41 publications with HEXA and Lung
Intestine Antibodies	>39 publications with HEXA and Intestine
Testis Antibodies	>18 publications with HEXA and Testis
Stomach Antibodies	>16 publications with HEXA and Stomach
Eye Antibodies	>14 publications with HEXA and Eye
Placenta Antibodies	>13 publications with HEXA and Placenta