Human HEXB cDNA Clone Expression Plasmid – Cat# MBS1275912

HEXB cDNA Clone – Hexosaminidase B (Beta Polypeptide) (Human)

Name: HEXB cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1275912
Price: 650 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1275912

MBS1275912 is a cDNA clone targeting HEXB. More details

$650 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

HEXB, cDNA Clone

Full Product Name

HEXB cDNA Clone

Product Gene Name

HEXB cdna clone

Sequence

atggagctgt gcgggctggg gctgccccgg ccgcccatgc tgctggcgct gctgttggcg acactgctgg cggcgatgtt ggcgctgctg actcaggtgg cgctggtggt gcaggtggcg gaggcggctc gggccccgag cgtctcggcc aagccggggc cggcgctgtg gcccctgccg ctctcggtga agatgacccc gaacctgctg catctcgccc cggagaactt ctacatcagc cacagcccca attccacggc gggcccctcc tgcaccctgc tggaggaagc gtttcgacga tatcatggct atatttttgg tttctacaag tggcatcatg aacctgctga attccaggct aaaacccagg ttcagcaact tcttgtctca atcacccttc agtcagagtg tgatgctttc cccaacatat cttcagatga gtcttatact ttacttgtga aagaaccagt ggctgtcctt aaggccaaca gagtttgggg agcattacga ggtttagaga cctttagcca gttagtttat caagattctt atggaacttt caccatcaat gaatccacca ttattgattc tccaaggttt tctcacagag gaattttgat tgatacatcc agacattatc tgccagttaa gattattctt aaaactctgg atgccatggc ttttaataag tttaatgttc ttcactggca catagttgat gaccagtctt tcccatatca gagcatcact tttcctgagt taagcaataa aggaagctat tctttgtctc atgtttatac accaaatgat gtccgtatgg tgattgaata tgccagatta cgaggaattc gagtcctgcc agaatttgat acccctgggc atacactatc ttggggaaaa ggtcagaaag acctcctgac tccatgttac agtagacaaa acaagttgga ctcttttgga cctataaacc ctactctgaa tacaacatac agcttcctta ctacattttt caaagaaatt agtgaggtgt ttccagatca attcattcat ttgggaggag atgaagtgga atttaaatgt tgggaatcaa atccaaaaat tcaagatttc atgaggcaaa aaggctttgg cacagatttt aagaaactag aatctttcta cattcaaaag gttttggata ttattgcaac cataaacaag ggatccattg tctggcagga ggtttttgat gataaagcaa agcttgcgcc gggcacaata gttgaagtat ggaaagacag cgcatatcct gaggaactca gtagagtcac agcatctggc ttccctgtaa tcctttctgc tccttggtac ttagatttga ttagctatgg acaagattgg aggaaatact ataaagtgga acctcttgat tttggcggta ctcagaaaca gaaacaactt ttcattggtg gagaagcttg tctatgggga gaatatgtgg atgcaactaa cctcactcca agattatggc ctcgggcaag tgctgttggt gagagactct ggagttccaa agatgtcaga gatatggatg acgcctatga cagactgaca aggcaccgct gcaggatggt cgaacgtgga atagctgcac aacctcttta tgctggatat tgtaaccatg agaacatgta a

Molecular Weight

63,111 Da

OMIM

268800

Vector

Please Inquire

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of HEXB cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for HEXB. It may not necessarily be applicable to this product.

NCBI GI #

34782797

NCBI GeneID

3074

NCBI Accession #

BC017378

UniProt Related Accession #

P07686

NCBI Official Full Name

Homo sapiens hexosaminidase B (beta polypeptide), mRNA

NCBI Official Synonym Full Names

hexosaminidase subunit beta

NCBI Official Symbol

HEXB

NCBI Official Synonym Symbols

ENC-1AS; HEL-248; HEL-S-111

UniProt Protein Name

Beta-hexosaminidase subunit beta

UniProt Synonym Protein Names

Beta-N-acetylhexosaminidase subunit beta; Hexosaminidase subunit B

Protein Family

Beta-hexosaminidase

UniProt Gene Name

HEXB

UniProt Synonym Gene Names

Hexosaminidase subunit B; HCC-7

UniProt Entry Name

HEXB_HUMAN

NCBI Protein Information

beta-hexosaminidase subunit beta

NCBI Summary for HEXB

Hexosaminidase B is the beta subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Beta subunit gene mutations lead to Sandhoff disease (GM2-gangliosidosis type II). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

UniProt Comments for HEXB

HEXB: Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues. Defects in HEXB are the cause of GM2-gangliosidosis type 2 (GM2G2); also known as Sandhoff disease. GM2- gangliosidosis is an autosomal recessive lysosomal storage disease marked by the accumulation of GM2 gangliosides in the neuronal cells. GM2G2 is clinically indistinguishable from GM2- gangliosidosis type 1, presenting startle reactions, early blindness, progressive motor and mental deterioration, macrocephaly and cherry-red spots on the macula. Belongs to the glycosyl hydrolase 20 family.

Protein type: Glycan Metabolism - other glycan degradation; Glycan Metabolism - glycosphingolipid biosynthesis - ganglio series; Glycan Metabolism - glycosphingolipid biosynthesis - globo series; EC 3.2.1.52; Hydrolase; Carbohydrate Metabolism - amino sugar and nucleotide sugar; Glycan Metabolism - glycosaminoglycan degradation

Chromosomal Location of Human Ortholog: 5q13

Cellular Component: azurophil granule; lysosomal lumen; membrane

Molecular Function: acetylglucosaminyltransferase activity; beta-N-acetylhexosaminidase activity; protein heterodimerization activity; protein homodimerization activity

Biological Process: chondroitin sulfate catabolic process; glycosphingolipid metabolic process; hyaluronan catabolic process; keratan sulfate catabolic process

Disease: Sandhoff Disease

Research Articles on HEXB

1. The absence of beta-N-acetyl-hexosaminidase activity does not alter the differentiation of i-DCs from HSCs, but it is critical for the activation of CD4(+)T cells because knock-down of HEXA or HEXB gene causes a loss of function of i-DCs.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with HEXB cdna clone

Products by Pathway	Pathway Diagram
Amino Sugar And Nucleotide Sugar Metabolism Pathway antibodies	Amino Sugar And Nucleotide Sugar Metabolism Pathway Diagram
Amino Sugar And Nucleotide Sugar Metabolism Pathway antibodies	Amino Sugar And Nucleotide Sugar Metabolism Pathway Diagram
CS/DS Degradation Pathway antibodies	CS/DS Degradation Pathway Diagram
Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway antibodies	Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
Glycosaminoglycan Degradation Pathway antibodies	Glycosaminoglycan Degradation Pathway Diagram
Glycosaminoglycan Degradation Pathway antibodies	Glycosaminoglycan Degradation Pathway Diagram
Glycosaminoglycan Metabolism Pathway antibodies	Glycosaminoglycan Metabolism Pathway Diagram
Glycosphingolipid Biosynthesis - Ganglio Series Pathway antibodies	Glycosphingolipid Biosynthesis - Ganglio Series Pathway Diagram
Glycosphingolipid Biosynthesis - Ganglio Series Pathway antibodies	Glycosphingolipid Biosynthesis - Ganglio Series Pathway Diagram

Diseases associated with HEXB cdna clone

Disease Name	Pubmed Publications
Sandhoff Disease Antibodies	>111 publications with HEXB and Sandhoff Disease
Brain Diseases Antibodies	>108 publications with HEXB and Brain Diseases
Liver Diseases Antibodies	>8 publications with HEXB and Liver Diseases
Kidney Diseases Antibodies	>7 publications with HEXB and Kidney Diseases
Neoplasms Antibodies	>6 publications with HEXB and Neoplasms
Inflammation Antibodies	>4 publications with HEXB and Inflammation
Nerve Degeneration Antibodies	>2 publications with HEXB and Nerve Degeneration
Hypertrophy Antibodies	>1 publications with HEXB and Hypertrophy
Fibrosis Antibodies	>1 publications with HEXB and Fibrosis
Necrosis Antibodies	>1 publications with HEXB and Necrosis

Organs/Tissues associated with HEXB cdna clone

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>44 publications with HEXB and Brain
Blood Antibodies	>17 publications with HEXB and Blood
Liver Antibodies	>13 publications with HEXB and Liver
Kidney Antibodies	>11 publications with HEXB and Kidney
Bone Antibodies	>8 publications with HEXB and Bone
Bone Marrow Antibodies	>5 publications with HEXB and Bone Marrow
Testis Antibodies	>5 publications with HEXB and Testis
Muscle Antibodies	>5 publications with HEXB and Muscle
Ovary Antibodies	>4 publications with HEXB and Ovary
Skin Antibodies	>3 publications with HEXB and Skin