Human HGS cDNA Clone Expression Plasmid – Cat# MBS1272904

HGS cDNA Clone – Hepatocyte Growth Factor-Regulated Tyrosine Kinase Substrate (Human)

Name: HGS cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1272904
Price: 880 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1272904

MBS1272904 is a cDNA clone targeting HGS. More details

$880 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

HGS, cDNA Clone

Full Product Name

HGS cDNA Clone

Product Gene Name

HGS cdna clone

Sequence

atggggcgag gcagcggcac cttcgagcgt ctcctagaca aggcgaccag ccagctcctg ttggagacag attgggagtc cattttgcag atctgcgacc tgatccgcca aggggacaca caagcaaaat atgctgtgaa ttccatcaag aagaaagtca acgacaagaa cccacacgtc gccttgtatg ccctggaggt catggaatct gtggtaaaga actgtggcca gacagttcat gatgaggtgg ccaacaagca gaccatggag gagctgaagg acctgctgaa gagacaagtg gaggtaaacg tccgtaacaa gatcctgtac ctgatccagg cctgggcgca tgccttccgg aacgagccca agtacaaggt ggtccaggac acctaccaga tcatgaaggt ggaggggcac gtctttccag aattcaaaga gagcgatgcc atgtttgctg ccgagagagc cccagactgg gtggacgctg aggaatgcca ccgctgcagg gtgcagttcg gggtgatgac ccgtaagcac cactgccggg cgtgtgggca gatattctgt ggaaagtgtt cttccaagta ctccaccatc cccaagtttg gcatcgagaa ggaggtgcgc gtgtgtgagc cctgctacga gcagctgaac aggaaagcgg agggaaaggc cacttccacc actgagctgc cccccgagta cctgaccagc cccctgtctc agcagtccca gctgcccccc aagagggacg agacggccct gcaggaggag gaggagctgc agctggccct ggcgctgtca cagtcagagg cggaggagaa ggagaggctg agacagaagt ccacgtacac ttcgtacccc aaggcggagc ccatgccctc ggcctcctca gcgccccccg ccagcagcct gtactcttca cctgtgaact cgtcggcgcc tctggctgag gacatcgacc ctgagctcgc acggtatctc aaccggaact actgggagaa gaagcaggag gaggctcgca agagccccac gccatctgcg cccgtgcccc tgacggagcc ggctgcacag cctggggaag ggcacgcagc ccccaccaac gtggtggaga accccctccc ggagacagac tctcagccca ttcctccctc tggtggcccc tttagtgagc cacagttcca caatggcgag tctgaggaga gccacgagca gttcctgaag gcgctgcaga acgccgtcac caccttcgtg aaccgcatga agagtaacca catgcggggc cgcagcatca ccaatgactc ggccgtgctc tcactcttcc agtccatcaa cggcatgcac ccgcagctgc tggagctgct caaccagctg gacgagcgca ggctgtacta tgaggggctg caggacaagc tggcacagat ccgcgatgcc cggggggcgc tgagtgccct gcgcgaagag caccgggaga agcttcgccg ggcagccgag gaggcagagc gccagcgcca gatccagctg gcccagaagc tggagataat gcggcagaag aagcaggagt acctggaggt gcagaggcag ctggccatcc agcgcctgca ggagcaggag aaggagcggc agatgcggct ggagcagcag aagcagacgg tccagatgcg cgcgcagatg cccgccttcc ccctgcccta cgcccagctc caggccatgc ccgcagccgg aggtgtgctc taccagccct cgggaccagc cagcttcccc agcaccttca gccctgccgg ctcggtggag ggctccccaa tgcacggcgt gtacatgagc cagccggccc ctgccgctgg cccctacccc agcatgccca gcactgcggc tgatcccagc atggtgagtg cctacatgta cccagcaggg gccactgggg cgcaggcggc cccccaggcc caggccggac ccaccgccag ccccgcttac tcatcctacc agcctactcc cacagcgggc taccagaacg tggcctccca ggccccacag agcctcccgg ccatctctca gcctccgcag tccagcacca tgggctacat ggggagccag tcagtctcca tgggctacca gccttacaac atgcagaatc tcatgaccac cctcccaagc caggatgcgt ctctgccacc ccagcagccc tacatcgcgg ggcagcagcc catgtaccag cagatggcac cctctggcgg tcccccccag cagcagcccc ccgtggccca gcaaccgcag gcacaggggc cgccggcaca gggcagcgag gcccagctca tttcattcga ctga

Molecular Weight

76,376 Da

OMIM

604375

Vector

Please Inquire

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of HGS cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for HGS. It may not necessarily be applicable to this product.

NCBI GI #

13097722

NCBI GeneID

9146

NCBI Accession #

BC003565

UniProt Secondary Accession #

Q9NR36

UniProt Related Accession #

O14964

NCBI Official Full Name

Homo sapiens hepatocyte growth factor-regulated tyrosine kinase substrate, mRNA

NCBI Official Synonym Full Names

hepatocyte growth factor-regulated tyrosine kinase substrate

NCBI Official Symbol

HGS

NCBI Official Synonym Symbols

HRS

UniProt Protein Name

Hepatocyte growth factor-regulated tyrosine kinase substrate

UniProt Synonym Protein Names

Hrs

Protein Family

Hepatocyte growth factor-regulated tyrosine kinase substrate

UniProt Gene Name

HGS

UniProt Synonym Gene Names

HRS

UniProt Entry Name

HGS_HUMAN

NCBI Protein Information

hepatocyte growth factor-regulated tyrosine kinase substrate

NCBI Summary for HGS

The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation. [provided by RefSeq, Dec 2010]

UniProt Comments for HGS

Hrs: a zinc finger protein which is rapidly tyrosine phosphorylated in cells stimulated with various growth factors. Hrs mRNA is expressed in all the human adult and fetal tissues tested.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17q25

Cellular Component: cytoplasm; cytosol; early endosome; endosome; intracellular membrane-bound organelle

Molecular Function: protein binding; protein domain specific binding

Biological Process: autophagy; endosome transport; membrane invagination; negative regulation of cell proliferation; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of JAK-STAT cascade; protein targeting to lysosome; regulation of MAP kinase activity; regulation of protein catabolic process; signal transduction

Research Articles on HGS

1. detailed analysis of the subcellular localization and functional significance of Hrs in macropinocytosis-mediated entry of Kaposi's Sarcoma-Associated Herpesvirus

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with HGS cdna clone

Products by Pathway	Pathway Diagram
CXCR4-mediated Signaling Events Pathway antibodies	CXCR4-mediated Signaling Events Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
EGFR Downregulation Pathway antibodies	EGFR Downregulation Pathway Diagram
ESCRT-0 Complex Pathway antibodies	ESCRT-0 Complex Pathway Diagram
Endocytosis Pathway antibodies	Endocytosis Pathway Diagram
Endocytosis Pathway antibodies	Endocytosis Pathway Diagram
Endosomal Sorting Complex Required For Transport (ESCRT) Pathway antibodies	Endosomal Sorting Complex Required For Transport (ESCRT) Pathway Diagram
Internalization Of ErbB1 Pathway antibodies	Internalization Of ErbB1 Pathway Diagram
Membrane Trafficking Pathway antibodies	Membrane Trafficking Pathway Diagram
Phagosome Pathway antibodies	Phagosome Pathway Diagram

Diseases associated with HGS cdna clone

Disease Name	Pubmed Publications
Necrosis Antibodies	>30 publications with HGS and Necrosis
Drug Toxicity Antibodies	>29 publications with HGS and Drug Toxicity
Nervous System Diseases Antibodies	>22 publications with HGS and Nervous System Diseases
Death Antibodies	>22 publications with HGS and Death
Immune System Diseases Antibodies	>22 publications with HGS and Immune System Diseases
Liver Diseases Antibodies	>19 publications with HGS and Liver Diseases
Kidney Diseases Antibodies	>18 publications with HGS and Kidney Diseases
Inflammation Antibodies	>16 publications with HGS and Inflammation
Poisoning Antibodies	>13 publications with HGS and Poisoning
Heart Diseases Antibodies	>9 publications with HGS and Heart Diseases

Organs/Tissues associated with HGS cdna clone

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>82 publications with HGS and Blood
Muscle Antibodies	>54 publications with HGS and Muscle
Brain Antibodies	>43 publications with HGS and Brain
Kidney Antibodies	>31 publications with HGS and Kidney
Liver Antibodies	>26 publications with HGS and Liver
Bone Antibodies	>21 publications with HGS and Bone
Nerve Antibodies	>17 publications with HGS and Nerve
Heart Antibodies	>13 publications with HGS and Heart
Lung Antibodies	>11 publications with HGS and Lung
Skin Antibodies	>10 publications with HGS and Skin