Human HLA-A cDNA Clone Expression Plasmid – Cat# MBS1269889

HLA-A cDNA Clone – Major Histocompatibility Complex, Class I, A (Human)

Name: HLA-A cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1269889
Price: 235 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1269889

MBS1269889 is a cDNA clone targeting HLA-A. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

HLA-A, cDNA Clone

Full Product Name

HLA-A cDNA Clone

Product Gene Name

HLA-A cdna clone

Sequence

atggccgtca tggcgccccg aaccctcgtc ctgctactct cgggggctct ggccctgacc cagacctggg cgggctctca ctccatgagg tatttcttca catccgtgtc ccggcccggc cgcggggagc cccgcttcat cgcagtgggc tacgtggacg acacgcagtt cgtgcggttc gacagcgacg ccgcgagcca gaggatggag ccgcgggcgc cgtggataga gcaggagggt ccggagtatt gggacgggga gacacggaaa gtgaaggccc actcacagac tcaccgagtg gacctgggga ccctgcgcgg ctactacaac cagagcgagg ccggttctca caccgtccag aggatgtatg gctgcgacgt ggggtcggac tggcgcttcc tccgcgggta ccaccagtac gcctacgacg gcaaggatta catcgccctg aaagaggacc tgcgcccttg gaccgcggcg gacatggcag ctcagaccac caagcacaag tgggaggcgg cccatgtggc ggagcagttg agagcctacc tggagggcac gtgcgtggag tggctccgca gatacctgga gaacgggaag gagacgctgc agcgcacgga cgcccccaaa acgcatatga ctcaccacgc tgtctctgac catgaagcca ccctgaggtg ctgggccctg agcttctacc ctgcggagat cacactgacc tggcagcggg atggggagga ccagacccag gacacggagc tcgtggagac caggcctgca ggggatggaa ccttccagaa gtgggcggct gtggtggtgc cttctggaca ggagcagaga tacacctgcc atgtgcagca tgagggtttg cccaagcccc tcaccctgag atgggagccg tcttcccagc ccaccatccc catcgtgggc atcattgctg gcctggttct ctttggagct gtgatcactg gagctgtggt cgctgctgtg atgtggagga ggaagagctc agatagaaaa ggagggagct actctcaggc tgcaagcagt gacagtgccc agggctctga tgtgtctctc acagcttgta aagtgtga

Molecular Weight

40,922 Da

OMIM

142800

Vector

pENTR223.1

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of HLA-A cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for HLA-A. It may not necessarily be applicable to this product.

NCBI GI #

37589079

NCBI GeneID

3105

NCBI Accession #

BC019236

UniProt Secondary Accession #

O19619; P06338; P10313; P30444; P30445; P30446; P30514; Q29680; Q29837; Q29899; Q95352

UniProt Related Accession #

P01892; P13746; P18462; P30443; P30447; P30453; P30455; P30456; P30457; P30459

NCBI Official Full Name

Homo sapiens major histocompatibility complex, class I, A, mRNA

NCBI Official Synonym Full Names

major histocompatibility complex, class I, A

NCBI Official Symbol

HLA-A

NCBI Official Synonym Symbols

HLAA

UniProt Protein Name

HLA class I histocompatibility antigen, A-2 alpha chain

UniProt Synonym Protein Names

MHC class I antigen A*2

Protein Family

HLA class I histocompatibility antigen

UniProt Gene Name

HLA-A

UniProt Synonym Gene Names

HLAA

UniProt Entry Name

1A02_HUMAN

NCBI Protein Information

HLA class I histocompatibility antigen, A-1 alpha chain

NCBI Summary for HLA-A

HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq, Jul 2008]

UniProt Comments for HLA-A

HLAA: Involved in the presentation of foreign antigens to the immune system. Belongs to the MHC class I family.

Protein type: Immunoglobulin superfamily; Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: cell surface; early endosome membrane; endoplasmic reticulum; Golgi apparatus; Golgi membrane; MHC class I protein complex; phagocytic vesicle membrane; plasma membrane

Molecular Function: beta-2-microglobulin binding; peptide antigen binding; protein binding

Biological Process: antigen processing and presentation; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; antigen processing and presentation of peptide antigen via MHC class I; regulation of immune response

Disease: Severe Cutaneous Adverse Reaction, Susceptibility To

Research Articles on HLA-A

1. Vitiligo risk associated with the MHC class I region thus derives from combined quantitative and qualitative phenomena: a SNP haplotype in a transcriptional regulator that induces gain-of-function, elevating expression of HLA-A RNA

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with HLA-A cdna clone

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Allograft Rejection Pathway antibodies	Allograft Rejection Pathway Diagram
Allograft Rejection Pathway antibodies	Allograft Rejection Pathway Diagram
Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway antibodies	Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway Diagram
Antigen Processing And Presentation Pathway antibodies	Antigen Processing And Presentation Pathway Diagram
Antigen Processing And Presentation Pathway antibodies	Antigen Processing And Presentation Pathway Diagram
Antigen Processing-Cross Presentation Pathway antibodies	Antigen Processing-Cross Presentation Pathway Diagram
Autoimmune Thyroid Disease Pathway antibodies	Autoimmune Thyroid Disease Pathway Diagram
Autoimmune Thyroid Disease Pathway antibodies	Autoimmune Thyroid Disease Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram

Organs/Tissues associated with HLA-A cdna clone

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>6994 publications with HLA-A and Blood
Kidney Antibodies	>1001 publications with HLA-A and Kidney
Bone Antibodies	>898 publications with HLA-A and Bone
Liver Antibodies	>454 publications with HLA-A and Liver
Skin Antibodies	>419 publications with HLA-A and Skin
Lung Antibodies	>367 publications with HLA-A and Lung
Lymph Antibodies	>190 publications with HLA-A and Lymph
Prostate Antibodies	>156 publications with HLA-A and Prostate
Embryonic Tissue Antibodies	>144 publications with HLA-A and Embryonic Tissue
Placenta Antibodies	>140 publications with HLA-A and Placenta