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HPGDS cDNA Clone – Hematopoietic Prostaglandin D Synthase

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS200632

Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. The enzyme catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this enzyme can be… More details

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Product Overview

Online Datasheet in PDF
Product Name
HPGDS, cDNA Clone
Full Product Name
HPGDS
Product Gene Name
HPGDS cdna clone
Product Synonym Names
GSTS; GSTS1; GSTS1-1; PGD2; PGDS
Sequence
Nucleotide Sequence: ATGCCAAACT ACAAACTCAC TTATTTTAAT ATGAGGGGGA GAGCAGAAAT TATTCGTTAC ATATTTGCTT ATTTGGACAT ACAGTATGAA GACCACAGAA TAGAACAAGC TGACTGGCCT GAAATCAAAT CAACTCTCCC ATTTGGAAAA ATCCCCATTT TGGAAGTTGA TGGACTTACT CTTCACCAGA GCCTAGCAAT AGCAAGATAT TTGACCAAAA ACACAGATTT GGCTGGAAAC ACAGAAATGG AACAATGTCA TGTTGATGCT ATTGTGGACA CTCTGGATGA TTTCATGTCA TGTTTTCCTT GGGCAGAGAA AAAGCAAGAT GTGAAAGAGC AGATGTTCAA TGAGCTGCTC ACGTATAATG CGCCTCATCT TATGCAAGAC TTGGACACAT ATTTAGGGGG GAGAGAATGG CTTATTGGTA ACTCTGTAAC TTGGGCAGAC TTCTACTGGG AGATTTGCAG TACCACACTT TTGGTCTTTA AGCCTGACCT GTTAGACAAC CATCCAAGGC TGGTGACTTT ACGGAAGAAA GTCCAAGCCA TTCCTGCCGT CGCTAACTGG ATAAAACGAA GGCCCCAAAC CAAACTCTAG

Tr anslation Sequence: MPNYKLTYFN MRGRAEIIRY IFAYLDIQYE DHRIEQADWP EIKSTLPFGK IPILEVDGLT LHQSLAIARY LTKNTDLAGN TEMEQCHVDA IVDTLDDFMS CFPWAEKKQD VKEQMFNELL TYNAPHLMQD LDTYLGGREW LIGNSVTWAD FYWEICSTTL LVFKPDLLDN HPRLVTLRKK VQAIPAVANW IKRRPQTKL
Form/Format
Lyophilized
Preparation and Storage
Store the plasmid at -20 degree C.
OMIM
602598
3D Structure
ModBase 3D Structure for O60760
Species
Human
Chromosome Location
4q22.3
OMIM Reference Number
602598
cDNA Size
600bp
Vector Description
This shuttle vector contains the complete ORF. It is inseted BamH I to Xho I. The gene insert contains multiple cloning sites which can be used to easily cut and transfer the gene and recombination site into your expression vector.
Vector
(puc19-derived cloning vector)
Preparation Before Usage
1. Centrifuge at 7000rpm for 1 minute. 2. Carefully open the vial and add 100ul of sterile water to dissolve the DNA. Each tube contains approximately 10ug of lyophilized plasmid.

Product Categories/Family for HPGDS cdna clone

Signal Transduction

Other Notes

Small volumes of HPGDS cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HPGDS purchase

MBS200632 is a cDNA clone targeting HPGDS.

Additional Details

NCBI/Uniprot data below describe general gene information for HPGDS. It may not necessarily be applicable to this product.

NCBI GI #
7657457
NCBI GeneID
27306
NCBI Accession #
NP_055300.1
UniProt Primary Accession #
O60760
UniProt Related Accession #
O60760
GenBank Nucleotide #
NM_014485.2
NCBI Official Full Name
hematopoietic prostaglandin D synthase
NCBI Official Synonym Full Names
hematopoietic prostaglandin D synthase
NCBI Official Symbol
HPGDS
NCBI Official Synonym Symbols
GSTS; PGD2; PGDS; GSTS1; GSTS1-1
UniProt Protein Name
Hematopoietic prostaglandin D synthase
UniProt Synonym Protein Names
GST class-sigma; Glutathione S-transferase (EC:2.5.1.18); Glutathione-dependent PGD synthase; Glutathione-requiring prostaglandin D synthase; Prostaglandin-H2 D-isomerase
Protein Family
Hematopoietic prostaglandin D synthase
UniProt Gene Name
HPGDS
UniProt Synonym Gene Names
GSTS; PGDS; PTGDS2; H-PGDS
UniProt Entry Name
HPGDS_HUMAN
NCBI Protein Information
hematopoietic prostaglandin D synthase

UniProt Comments for HPGDS

Ptgds2: Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide. Belongs to the GST superfamily. Sigma family.

Protein type: EC 2.5.1.18; Lipid Metabolism - arachidonic acid; EC 5.3.99.2; Isomerase

Chromosomal Location of Human Ortholog: 4q22.3

Cellular Component: cytoplasm; cytosol

Molecular Function: prostaglandin-D synthase activity; protein homodimerization activity; glutathione transferase activity; magnesium ion binding; calcium ion binding

Biological Process: xenobiotic metabolic process; cyclooxygenase pathway; arachidonic acid metabolic process; locomotory behavior; signal transduction; prostaglandin metabolic process
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Research Articles on HPGDS

1. we have utilized a broad-scaled affinity proteomics approach to identify three proteins (CCL5, HPGDS, and NPSR1) with altered plasma levels in asthmatic children compared to healthy controls, representing the first evaluation of HPGDS and NPSR1 in plasma.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with HPGDS cdna clone

 Reference Product  PubMed Publications
 PTGS2 cdna clone  >12 publications with HPGDS and PTGS2
 PTGS1 cdna clone  >7 publications with HPGDS and PTGS1
 PTGDS cdna clone  >3 publications with HPGDS and PTGDS
 AKR1C3 cdna clone  >2 publications with HPGDS and AKR1C3
 PTGIS cdna clone  >1 publications with HPGDS and PTGIS
 PTGES2 cdna clone  >1 publications with HPGDS and PTGES2
 TBXAS1 cdna clone  >1 publications with HPGDS and TBXAS1
 PTGES cdna clone  >1 publications with HPGDS and PTGES

Pathways associated with HPGDS cdna clone

 Products by Pathway  Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 C20 Prostanoid Biosynthesis Pathway antibodies  C20 Prostanoid Biosynthesis Pathway Diagram
 C20 Prostanoid Biosynthesis Pathway antibodies  C20 Prostanoid Biosynthesis Pathway Diagram
 Defective AHCY Causes Hypermethioninemia With S-adenosylhomocysteine Hydrolase Deficiency (HMAHCHD) Pathway antibodies  Defective AHCY Causes Hypermethioninemia With S-adenosylhomocysteine Hydrolase Deficiency (HMAHCHD) Pathway Diagram
 Defective GCLC Causes Hemolytic Anemia Due To Gamma-glutamylcysteine Synthetase Deficiency (HAGGSD) Pathway antibodies  Defective GCLC Causes Hemolytic Anemia Due To Gamma-glutamylcysteine Synthetase Deficiency (HAGGSD) Pathway Diagram
 Defective GGT1 Causes Glutathionuria (GLUTH) Pathway antibodies  Defective GGT1 Causes Glutathionuria (GLUTH) Pathway Diagram
 Defective GSS Causes Glutathione Synthetase Deficiency (GSS Deficiency) Pathway antibodies  Defective GSS Causes Glutathione Synthetase Deficiency (GSS Deficiency) Pathway Diagram

Diseases associated with HPGDS cdna clone

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >14 publications with HPGDS and Inflammation
 Nervous System Diseases Antibodies  >6 publications with HPGDS and Nervous System Diseases
 Disease Models, Animal Antibodies  >5 publications with HPGDS and Disease Models, Animal
 Necrosis Antibodies  >2 publications with HPGDS and Necrosis
 Cardiovascular Diseases Antibodies  >2 publications with HPGDS and Cardiovascular Diseases
 Prenatal Exposure Delayed Effects Antibodies  >1 publications with HPGDS and Prenatal Exposure Delayed Effects
 Neoplasms, Experimental Antibodies  >1 publications with HPGDS and Neoplasms, Experimental
 Cell Transformation, Neoplastic Antibodies  >1 publications with HPGDS and Cell Transformation, Neoplastic
 Breast Neoplasms Antibodies  >1 publications with HPGDS and Breast Neoplasms
 Edema Antibodies  >1 publications with HPGDS and Edema

Organs/Tissues associated with HPGDS cdna clone

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >7 publications with HPGDS and Blood
 Brain Antibodies  >6 publications with HPGDS and Brain
 Connective Tissue Antibodies  >1 publications with HPGDS and Connective Tissue
 Placenta Antibodies  >1 publications with HPGDS and Placenta
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