Human IFNAR1 cDNA Clone Expression Plasmid – Cat# MBS1272848

IFNAR1 cDNA Clone – Interferon (Alpha, Beta and Omega) Receptor 1 (Human)

Name: IFNAR1 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1272848
Price: 235 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1272848

MBS1272848 is a cDNA clone targeting IFNAR1. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

IFNAR1, cDNA Clone

Full Product Name

IFNAR1 cDNA Clone

Product Gene Name

IFNAR1 cdna clone

Sequence

atgatggtcg tcctcctggg cgcgacgacc ctagtgctcg tcgccgtggc gccatgggtg ttgtccgcag ccgcaggtgg aaaaaatcta aaatctcctc aaaaagtaga ggtcgacatc atagatgaca actttatcct gaggtggaac aggagcgatg agtctgtcgg gaatgtgact ttttcattcg attatcaaaa aactgggatg gataattgga taaaattgtc tgggtgtcag aatattacta gtaccaaatg caacttttct tcactcaagc tgaatgttta tgaagaaatt aaattgcgta taagagcaga aaaagaaaac acttcttcat ggtatgaggt tgactcattt acaccatttc gcaaagctca gattggtcct ccagaagtac atttagaagc tgaagataag gcaatagtga tacacatctc tcctggaaca aaagatagtg ttatgtgggc tttggatggt ttaagcttta catatagctt agttatctgg aaaaactctt caggtgtaga agaaaggatt gaaaatattt attccagaca taaaatttat aaactctcac cagagactac ttattgtcta aaagttaaag cagcactact tacgtcatgg aaaattggtg tctatagtcc agtacattgt ataaagacca cagttgaaaa tgaactacct ccaccagaaa atatagaagt cagtgtccaa aatcagaact atgttcttaa atgggattat acatatgcaa acatgacctt tcaagttcag tggctccacg cctttttaaa aaggaatcct ggaaaccatt tgtataaatg gaaacaaata cctgactgtg aaaatgtcaa aactacccag tgtgtctttc ctcaaaacgt tttccaaaaa ggaatttacc ttctccgcgt acaagcatct gatggaaata acacatcttt ttggtctgaa gagataaagt ttgatactga aatacaagct ttcctacttc ctccagtctt taacattaga tcccttagtg attcattcca tatctatatc ggtgctccaa aacagtctgg aaacacgcct gtgatccagg attatccact gatttatgaa attatttttt gggaaaacac ttcaaatgct gagagaaaaa ttatcgagaa aaaaactgat gttacagttc ctaatttgaa accactgact gtatattgtg tgaaagccag agcacacacc atggatgaaa agctgaataa aagcagtgtt tttagtgacg ctgtatgtga gaaaacaaaa ccaggaaata cctctaaaat ttggcttata gttggaattt gtattgcatt atttgctctc ccgtttgtca tttatgctgc gaaagtcttc ttgagatgca tcaattatgt cttctttcca tcacttaaac cttcttccag tatagatgag tatttctctg aacagccatt gaagaatctt ctgctttcaa cttctgagga acaaatcgaa aaatgtttca taattgaaaa tataagcaca attgctacag tagaagaaac taatcaaact gatgaagatc ataaaaaata cagttcccaa actagccaag attcaggaaa ttattctaat gaagatgaaa gcgaaagtaa aacaagtgaa gaactacagc aggactttgt atga

Molecular Weight

56,046 Da

OMIM

107450

Vector

pENTR223.1

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of IFNAR1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for IFNAR1. It may not necessarily be applicable to this product.

NCBI GI #

18255501

NCBI GeneID

3454

NCBI Accession #

BC021825

UniProt Secondary Accession #

Q53GW9; Q53H11; Q6PKD7; Q7M4L2; Q8WTZ2; B2R6L9; B4DNT3; D3DSF0

UniProt Related Accession #

P17181

NCBI Official Full Name

Homo sapiens interferon (alpha, beta and omega) receptor 1, mRNA

NCBI Official Synonym Full Names

interferon alpha and beta receptor subunit 1

NCBI Official Symbol

IFNAR1

NCBI Official Synonym Symbols

AVP; IFRC; IFNAR; IFNBR; IFN-alpha-REC

UniProt Protein Name

Interferon alpha/beta receptor 1

UniProt Synonym Protein Names

Cytokine receptor class-II member 1; Cytokine receptor family 2 member 1; CRF2-1; Type I interferon receptor 1

Protein Family

Interferon alpha/beta receptor

UniProt Gene Name

IFNAR1

UniProt Synonym Gene Names

IFNAR; IFN-R-1; IFN-alpha/beta receptor 1; CRF2-1

UniProt Entry Name

INAR1_HUMAN

NCBI Protein Information

interferon alpha/beta receptor 1

NCBI Summary for IFNAR1

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. [provided by RefSeq, Jul 2008]

UniProt Comments for IFNAR1

IFNAR1: receptor for interferons alpha and beta. Belongs to the type II cytokine family of receptors. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves. Tyk2 tyrosine kinase is essential for stable cell surface expression of IFNAR1. Present in all tissues and even on the surface of most IFN-resistant cells.

Protein type: Receptor, cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 21q22.11

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: interferon-alpha/beta binding; interferon-alpha/beta receptor activity; protein binding

Biological Process: JAK-STAT cascade; response to lipopolysaccharide; response to virus

Research Articles on IFNAR1

1. data illustrate a lipid G-protein coupled receptor (GPCR)-IFNAR1 regulatory loop that balances effective and detrimental immune responses and elevated endogenous S1PR1 signaling

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with IFNAR1 cdna clone

Products by Pathway	Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Downstream Signaling In Naive CD8+ T Cells Pathway antibodies	Downstream Signaling In Naive CD8+ T Cells Pathway Diagram
Hepatitis B Pathway antibodies	Hepatitis B Pathway Diagram
Hepatitis C Pathway antibodies	Hepatitis C Pathway Diagram
Hepatitis C Pathway antibodies	Hepatitis C Pathway Diagram
Herpes Simplex Infection Pathway antibodies	Herpes Simplex Infection Pathway Diagram
Herpes Simplex Infection Pathway antibodies	Herpes Simplex Infection Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram

Diseases associated with IFNAR1 cdna clone

Disease Name	Pubmed Publications
Virus Diseases Antibodies	>83 publications with IFNAR1 and Virus Diseases
Neoplasms Antibodies	>44 publications with IFNAR1 and Neoplasms
Liver Diseases Antibodies	>42 publications with IFNAR1 and Liver Diseases
Inflammation Antibodies	>40 publications with IFNAR1 and Inflammation
Necrosis Antibodies	>20 publications with IFNAR1 and Necrosis
Carcinoma, Hepatocellular Antibodies	>10 publications with IFNAR1 and Carcinoma, Hepatocellular
Cardiovascular Diseases Antibodies	>7 publications with IFNAR1 and Cardiovascular Diseases
Drug Toxicity Antibodies	>5 publications with IFNAR1 and Drug Toxicity
Kidney Diseases Antibodies	>5 publications with IFNAR1 and Kidney Diseases
Fever Antibodies	>4 publications with IFNAR1 and Fever

Organs/Tissues associated with IFNAR1 cdna clone

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>98 publications with IFNAR1 and Blood
Liver Antibodies	>38 publications with IFNAR1 and Liver
Bone Antibodies	>34 publications with IFNAR1 and Bone
Bone Marrow Antibodies	>32 publications with IFNAR1 and Bone Marrow
Lung Antibodies	>22 publications with IFNAR1 and Lung
Brain Antibodies	>18 publications with IFNAR1 and Brain
Spleen Antibodies	>17 publications with IFNAR1 and Spleen
Lymph Node Antibodies	>10 publications with IFNAR1 and Lymph Node
Lymph Antibodies	>10 publications with IFNAR1 and Lymph
Skin Antibodies	>9 publications with IFNAR1 and Skin