Human IKZF3 cDNA Clone Expression Plasmid – Cat# MBS1274025

IKZF3 cDNA Clone – IKAROS Family Zinc Finger 3 (Aiolos) (Human)

Name: IKZF3 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1274025
Price: 400 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1274025

MBS1274025 is a cDNA clone targeting IKZF3. More details

$400 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

IKZF3, cDNA Clone

Full Product Name

IKZF3 cDNA Clone

Product Gene Name

IKZF3 cdna clone

Sequence

atggaagata tacaaacaaa tgcggaactg aaaagcactc aggagcagtc tgtgcccgca gaaagtgcag cggttttgaa tgactacagt ttaaccaaat ctcatgaaat ggaaaatgtg gacagtggag aaggcccagc caatgaagat gaagacatag gagatgattc aatgaaagtg aaagatgaat acagtgaaag agatgagaat gttttaaagt cagaacccat gggaaatgca gaagagcctg aaatccctta cagctattca agagaatata atgaatatga aaacattaag ttggagagac atgttgtctc attcgatagt agcaggccaa ccagtggaaa gatgaactgc gatgtgtgtg gattatcctg catcagcttc aatgtcttaa tggttcataa gcgaagccat actggtgaac gcccattcca gtgtaatcag tgtggggcat cttttactca gaaaggtaac ctcctccgcc acattaaact gcacacaggg gaaaaacctt ttaagtgtca cctctgcaac tatgcatgcc aaagaagaga tgcgctcacg gggcatctta ggacacattc tgtggagaaa ccctacaaat gtgagttttg tggaaggagt tacaagcaga gaagttccct tgaggagcac aaggagcgct gccgtacatt tcttcagagc actgacccag gggacactgc aagtgcggag gcaagacaca tcaaagcaga gatgggaagt gaaagagctc tcgtactgga cagattagca agcaatgtgg caaaacgaaa aagctcaatg cctcagaaat tcattggtga gaagcgccac tgctttgatg tcaactataa ttcaagttac atgtatgaga aagagagtga gctcatacag acccgcatga tggaccaagc catcaataac gccatcagct atcttggcgc cgaagccctg cgccccttgg tccagacacc gcctgctccc acctcggaga tggttccagt tatcagcagc atgtatccca tagccctcac ccgggctgag atgtcaaacg gtgcccctca agagctggaa aagaaaagca tccaccttcc agagaagagc gtgccttctg agagaggcct ctctcccaac aatagtggcc acgactccac ggacactgac agcaaccatg aagaacgcca gaatcacatc tatcagcaaa atcacatggt cctgtctcgg gcccgcaatg ggatgccact tctgaaggag gttccccgct cttacgaact cctcaagccc ccgcccatct gcccaagaga ctccgtcaaa gtgatcaaca aggaagggga ggtgatggat gtgtatcggt gtgaccactg ccgcgtcctc ttcctggact atgtgatgtt cacgattcac atgggctgcc acggcttccg tgaccctttc gagtgtaaca tgtgtggata tcgaagccat gatcggtatg agttctcgtc tcacatagcc agaggagaac acagagccct gctgaagtga

Molecular Weight

29,973 Da

OMIM

606221

Vector

pENTR223.1 or pUC

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of IKZF3 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for IKZF3. It may not necessarily be applicable to this product.

NCBI GI #

21595808

NCBI GeneID

22806

NCBI Accession #

BC032707

UniProt Secondary Accession #

Q69BL6; Q69BL7; Q69BL8; Q69BL9; Q69BM0; Q69BM1; Q69BM2; Q69BM3; Q69BM5; Q8N574; B4DVV5

UniProt Related Accession #

Q9UKT9

NCBI Official Full Name

Homo sapiens IKAROS family zinc finger 3 (Aiolos), mRNA

NCBI Official Synonym Full Names

IKAROS family zinc finger 3

NCBI Official Symbol

IKZF3

NCBI Official Synonym Symbols

AIO; AIOLOS; ZNFN1A3

UniProt Protein Name

Zinc finger protein Aiolos

UniProt Synonym Protein Names

Ikaros family zinc finger protein 3

Protein Family

Zinc finger protein

UniProt Gene Name

IKZF3

UniProt Synonym Gene Names

ZNFN1A3

UniProt Entry Name

IKZF3_HUMAN

NCBI Protein Information

zinc finger protein Aiolos

NCBI Summary for IKZF3

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012]

UniProt Comments for IKZF3

Aiolos: a transcription factor of the ikaros C2H2-type zinc-finger protein family. Plays an important role in the regulation of lymphocyte differentiation. Deletions in Aiolos have been observed in a subset of pre-B-cell acute lymphoblastic leukemia (B-ALL) cases. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: cytoplasm; nucleus; plasma membrane

Molecular Function: identical protein binding; protein binding; protein heterodimerization activity; protein homodimerization activity; sequence-specific DNA binding; transcription factor activity

Biological Process: mesoderm development; positive regulation of transcription from RNA polymerase II promoter; regulation of apoptosis; regulation of B cell differentiation; regulation of B cell proliferation; regulation of lymphocyte differentiation; regulation of transcription from RNA polymerase II promoter

Research Articles on IKZF3

1. Aiolos improved the survival of Nalm6 cells via PTEN and Aktdependent processes.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with IKZF3 cdna clone

Products by Pathway	Pathway Diagram
IL2-mediated Signaling Events Pathway antibodies	IL2-mediated Signaling Events Pathway Diagram

Diseases associated with IKZF3 cdna clone

Disease Name	Pubmed Publications
Neoplasms Antibodies	>17 publications with IKZF3 and Neoplasms
Lymphoma Antibodies	>8 publications with IKZF3 and Lymphoma
Inflammation Antibodies	>3 publications with IKZF3 and Inflammation
Precursor Cell Lymphoblastic Leukemia-Lymphoma Antibodies	>3 publications with IKZF3 and Precursor Cell Lymphoblastic Leukemia-Lymphoma
Breast Neoplasms Antibodies	>2 publications with IKZF3 and Breast Neoplasms
Hematologic Neoplasms Antibodies	>1 publications with IKZF3 and Hematologic Neoplasms
Carcinoma Antibodies	>1 publications with IKZF3 and Carcinoma
Neoplasms, Experimental Antibodies	>1 publications with IKZF3 and Neoplasms, Experimental
Leukemia, Myeloid, Acute Antibodies	>1 publications with IKZF3 and Leukemia, Myeloid, Acute
Leukemia, Myeloid Antibodies	>1 publications with IKZF3 and Leukemia, Myeloid

Organs/Tissues associated with IKZF3 cdna clone

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>37 publications with IKZF3 and Blood
Thymus Antibodies	>6 publications with IKZF3 and Thymus
Spleen Antibodies	>4 publications with IKZF3 and Spleen
Lung Antibodies	>3 publications with IKZF3 and Lung
Lymph Node Antibodies	>1 publications with IKZF3 and Lymph Node