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IMPACT cDNA Clone – Protein IMPACT

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS200967

IMPACT belongs to the IMPACT family and contains 1 RWD domain. It is translational regulator that ensures constant high levels of translation under amino acid starvation and acts by interacting with GCN1/GCN1L1, thereby preventing activation of GCN2 protein… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
IMPACT, cDNA Clone
Full Product Name
IMPACT
Product Gene Name
IMPACT cdna clone
Product Synonym Names
RWDD5
Sequence
Nucleotide Sequence: ATGGCTGAGG GGGACGCAGG GAGCGACCAG AGGCAGAATG AGGAAATTGA AGCAATGGCA GCCATTTATG GCGAGGAGTG GTGTGTCATT GATGACTGTG CCAAAATATT TTGTATTAGA ATTAGCGACG ATATAGATGA CCCCAAATGG ACACTTTGCT TGCAGGTGAT GCTGCCGAAT GAATACCCAG GTACAGCTCC ACCTATCTAC CAGTTGAATG CTCCTTGGCT TAAAGGGCAA GAACGTGCGG ATTTATCAAA TAGCCTTGAG GAAATATATA TTCAGAATAT CGGTGAAAGT ATTCTTTACC TGTGGGTGGA GAAAATAAGA GATGTTCTTA TACAAAAATC TCAGATGACA GAACCAGGCC CAGATGTAAA GAAGAAAACT GAAGAGGAAG ATGTTGAATG TGAAGATGAT CTCATTTTAG CATGTCAGCC GGAAAGTTCG GTTAAAGCAT TGGATTTTGA TATCAGTGAA ACTCGGACAG AAGTAGAAGT AGAAGAATTA CCTCCGATTG ATCATGGCAT TCCTATTACA GACCGAAGAA GTACTTTTCA GGCACACTTG GCTCCAGTGG TTTGTCCCAA ACAGGTGAAA ATGGTTCTTT CCAAATTGTA TGAGAATAAG AAAATAGCTA GTGCCACCCA CAACATCTAT GCCTACAGAA TATATTGTGA GGATAAACAG ACCTTCTTAC AGGATTGTGA GGATGATGGG GAAACAGCAG CTGGTGGGCG TCTTCTTCAT CTCATGGAGA TTTTGAATGT GAAGAATGTC ATGGTGGTAG TATCACGCTG GTATGGAGGG ATTCTGCTAG GACCAGATCG CTTTAAACAT ATCAACAACT GTGCCAGAAA CATACTAGTG GAAAAGAACT ACACAAATTC ACCTGAGGAG TCATCTAAGG CTTTGGGAAA GAACAAAAAA GTAAGAAAAG ACAAGAAGAG GAATGAACAT TAA

Translati on Sequence: MAEGDAGSDQ RQNEEIEAMA AIYGEEWCVI DDCAKIFCIR ISDDIDDPKW TLCLQVMLPN EYPGTAPPIY QLNAPWLKGQ ERADLSNSLE EIYIQNIGES ILYLWVEKIR DVLIQKSQMT EPGPDVKKKT EEEDVECEDD LILACQPESS VKALDFDISE TRTEVEVEEL PPIDHGIPIT DRRSTFQAHL APVVCPKQVK MVLSKLYENK KIASATHNIY AYRIYCEDKQ TFLQDCEDDG ETAAGGRLLH LMEILNVKNV MVVVSRWYGG ILLGPDRFKH INNCARNILV EKNYTNSPEE SSKALGKNKK VRKDKKRNEH
Form/Format
Lyophilized
Preparation and Storage
Store the plasmid at -20 degree C.
OMIM
615319
3D Structure
ModBase 3D Structure for Q9P2X3
Species
Human
Chromosome Location
18q11.2-q12.1
OMIM Reference Number
615319
cDNA Size
963bp
Vector Description
This shuttle vector contains the complete ORF. It is inseted BamH I to Xho I. The gene insert contains multiple cloning sites which can be used to easily cut and transfer the gene and recombination site into your expression vector.
Vector
(puc19-derived cloning vector)
Preparation Before Usage
1. Centrifuge at 7000rpm for 1 minute. 2. Carefully open the vial and add 100ul of sterile water to dissolve the DNA. Each tube contains approximately 10ug of lyophilized plasmid.

Product Categories/Family for IMPACT cdna clone

Epigenomics (Transcription & Translation)

Other Notes

Small volumes of IMPACT cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IMPACT purchase

MBS200967 is a cDNA clone targeting IMPACT.

Additional Details

NCBI/Uniprot data below describe general gene information for IMPACT. It may not necessarily be applicable to this product.

NCBI GI #
8923819
NCBI Accession #
NP_060909.1
UniProt Primary Accession #
Q9P2X3
GenBank Nucleotide #
NM_018439.3
NCBI Official Full Name
protein IMPACT
UniProt Protein Name
Protein IMPACT
UniProt Synonym Protein Names
Imprinted and ancient gene protein homolog
Protein Family
Protein
UniProt Gene Name
IMPACT
UniProt Entry Name
IMPCT_HUMAN

UniProt Comments for IMPACT

IMPACT: Translational regulator that ensures constant high levels of translation under amino acid starvation. Acts by interacting with GCN1/GCN1L1, thereby preventing activation of GCN2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis. Belongs to the IMPACT family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 18q11.2-q12.1

Cellular Component: cytoplasm

Biological Process: negative regulation of protein amino acid phosphorylation; regulation of translational initiation
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IMPACT cdna clone

 Reference Product  PubMed Publications
 LARGE cdna clone  >42448 publications with IMPACT and LARGE
 STS cdna clone  >427 publications with IMPACT and STS
 ATIC cdna clone  >6 publications with IMPACT and ATIC
 FXYD5 cdna clone  >4 publications with IMPACT and FXYD5
 BTG3 cdna clone  >2 publications with IMPACT and BTG3
 HADH cdna clone  >1 publications with IMPACT and HADH
 MAN2C1 cdna clone  >1 publications with IMPACT and MAN2C1
 ROM1 cdna clone  >1 publications with IMPACT and ROM1
 GCN1L1 cdna clone  >1 publications with IMPACT and GCN1L1

Diseases associated with IMPACT cdna clone

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >51142 publications with IMPACT and Nervous System Diseases
 Heart Diseases Antibodies  >26310 publications with IMPACT and Heart Diseases
 Inflammation Antibodies  >14199 publications with IMPACT and Inflammation
 Hypertension Antibodies  >12578 publications with IMPACT and Hypertension
 Kidney Diseases Antibodies  >10415 publications with IMPACT and Kidney Diseases
 Liver Diseases Antibodies  >10258 publications with IMPACT and Liver Diseases
 Neoplasm Metastasis Antibodies  >6224 publications with IMPACT and Neoplasm Metastasis
 Necrosis Antibodies  >6126 publications with IMPACT and Necrosis
 Lung Neoplasms Antibodies  >5769 publications with IMPACT and Lung Neoplasms
 Prostatic Diseases Antibodies  >5146 publications with IMPACT and Prostatic Diseases

Organs/Tissues associated with IMPACT cdna clone

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >31706 publications with IMPACT and Brain
 Heart Antibodies  >30950 publications with IMPACT and Heart
 Vascular Antibodies  >21392 publications with IMPACT and Vascular
 Bone Antibodies  >19511 publications with IMPACT and Bone
 Lung Antibodies  >17115 publications with IMPACT and Lung
 Liver Antibodies  >17067 publications with IMPACT and Liver
 Kidney Antibodies  >16109 publications with IMPACT and Kidney
 Muscle Antibodies  >14887 publications with IMPACT and Muscle
 Skin Antibodies  >10157 publications with IMPACT and Skin
 Eye Antibodies  >6788 publications with IMPACT and Eye
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