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INTS6 cDNA Clone – Integrator Complex Subunit 6 (Human)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1273989

MBS1273989 is a cDNA clone targeting INTS6. More details

$630 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
INTS6, cDNA Clone
Full Product Name
INTS6 cDNA Clone
Product Gene Name
INTS6 cdna clone
Sequence
atgcccatct tactgttcct gatagacacg tctgcctcta tgaaccagcg cagccatctg ggcaccacct acctggacac ggccaaaggc gcggtagaga ccttcatgaa gctccgtgcc cgggaccctg ccagcagagg agacaggtat atgctggtca ctttcgaaga gccgccctat gctatcaagg ctggatggaa agaaaaccat gcaacgttta tgaatgaatt gaaaaacctt caggctgaag gacttacgac tcttggccaa tccctaagga cagcttttga tttattaaat ttaaatagat tagtaactgg catagacaac tatgggcagg gaagaaaccc ttttttcttg gagccagcaa taattatcac aattactgat gggagcaagt tgactaccac cagtggagtc caggatgagc ttcatttacc tcttaattct cctttgcctg gaagtgaatt gaccaaggaa ccttttcgtt gggatcagag actctttgca ttagtgttgc ggttgcctgg caccatgtca gtagaatcag aacagttgac aggtgtgcct ttagatgact ctgcaatcac accaatgtgt gaagtgacag gcggccgttc atattctgtg tgttctccaa gaatgcttaa tcagtgtctg gagtccttgg tgcagaaagt acaaagtggg gtggtaataa actttgaaaa agcaggacca gatccttccc ctgtagaaga tgggcagcca gatatatcaa ggccttttgg atctcagcct tggcatagct gtcacaaact catatatgtc agaccaaatc ctaaaactgg ggttcctata ggtcattggc ctgttccaga gtctttttgg ccagatcaaa attcgccaac actaccacct cgtacatctc atcctgtagt gaagttttcc tgtacagact gtgaaccaat ggttattgat aaacttcctt ttgacaaata tgagttggaa ccttcaccac tgactcaatt tatcctggaa aggaaatctc ctcaaacatg ttggcaggtg tacgtgagca atagtgcaaa atacagtgaa cttggtcatc cttttggtta cttgaaagcc agtacagcac tgaactgtgt caacttattt gtgatgcctt acaattatcc agtccttctt cccctcttag atgacttgtt taaagtgcat aaagcaaaac caacattgaa gtggagacag tcatttgaaa gttatttgaa gacaatgcct ccctactatc ttgggccctt gaagaaagct gttaggatga tgggagcacc taacctaata gcagacagta tggaatatgg acttagttac agtgtcattt catacctcaa aaaactgagt caacaggcca aaatagaatc tgatcgagtc attggatctg taggcaaaaa agtagtacag gagactggaa taaaagtccg gagccgatca catggtttat caatggcata taggaaagat tttcaacaac tcctccaggg aatttcagag gatgtccctc acagactgct agaccttaat atgaaggaat acactgggtt ccaagttgct ttgctgaata aggatttgaa gccacagaca tttagaaatg cttatgacat accaagacga aatcttttgg atcacttaac aagaatgaga tctaatcttt tgaagagcac tcgcagattt ctgaaaggac aggacgaaga tcaagtgcac agtgttccta tagcacaaat ggggaactac caggaatacc tcaagcaagt accttctcca ctaagagaac ttgatcctga tcagccacga aggttgcata catttggcaa cccctttaag ctggataaga agggtatgat gatagatgaa gcagatgaat ttgtggctgg acctcaaaat aaacataaac gacccggaga accaaatatg caagggatcc ctaaaagacg tcggtgtatg tctccactac taagaggcag acagcagaat cctgttgtaa acaatcatat tgggggaaaa ggaccacctg cacctacaac tcaagcacag ccagatctta ttaaacctct tcctcttcat aaaatttcag aaaccactaa tgattcgata atacatgatg tggttgaaaa tcatgttgca gaccaacttt catcagacat tacaccaaat gctatggata cggaattttc agcatcttct ccagccagtt tactggaacg gccaaccaat catatggagg ctcttggtca tgaccattta ggaaccaatg acctcactgt tggtggattt ttagaaaatc atgaggagcc aagagataaa gaacaatgtg ctgaagagaa cataccagca tcttcactca acaaaggaaa gaaattgatg cattgcagaa gccatgaaga ggtcaatact gaactaaaag cacaaataat gaaagagatc cgaaagccag gaagaaaata tgaaagaatc ttcactttac tgaagcatgt gcaaggcagt ttacaaacaa gactaatatt tttacaaaat gtcattaaag aagcatcaag gtttaaaaaa cgaatgctaa tagaacaact ggagaacttc ttggatgaaa ttcatcgaag agccaatcag atcaaccata ttaatagcaa ttaa
Molecular Weight
98,987 Da
OMIM
604331
Vector
pENTR223.1 or pUC
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of INTS6 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for INTS6. It may not necessarily be applicable to this product.

NCBI GI #
24980820
NCBI GeneID
26512
NCBI Accession #
BC039829
UniProt Secondary Accession #
Q0P664; Q6PJP4; Q9UFK0; Q9Y5M9
UniProt Related Accession #
Q9UL03
NCBI Official Full Name
Homo sapiens integrator complex subunit 6, mRNA
NCBI Official Synonym Full Names
integrator complex subunit 6
NCBI Official Symbol
INTS6
NCBI Official Synonym Symbols
HDB; INT6; DBI-1; DDX26; DICE1; DDX26A; Notchl2
UniProt Protein Name
Integrator complex subunit 6
UniProt Synonym Protein Names
DBI-1; Protein DDX26; Protein deleted in cancer 1; DICE1
Protein Family
Integrator complex
UniProt Gene Name
INTS6
UniProt Synonym Gene Names
DBI1; DDX26; DDX26A; Int6; DICE1
UniProt Entry Name
INT6_HUMAN
NCBI Protein Information
integrator complex subunit 6

NCBI Summary for INTS6

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and is located in the critical region of loss of heterozygosity (LOH). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2015]
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UniProt Comments for INTS6

INTS6: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. May have a tumor suppressor role; an ectopic expression suppressing tumor cell growth. Belongs to the Integrator subunit 6 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA processing; Receptor, misc.

Chromosomal Location of Human Ortholog: 13q14.3

Cellular Component: actin cytoskeleton; integrator complex; nucleoplasm

Molecular Function: protein binding; transmembrane receptor activity

Biological Process: snRNA processing; snRNA transcription from RNA polymerase II promoter
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Research Articles on INTS6

1. Findings demonstrate INTS6P1 and INTS6 exert the tumor suppressive roles through competing for oncomiR-17-5p.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with INTS6 cdna clone

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >9 publications with INTS6 and Neoplasms
 Lung Neoplasms Antibodies  >4 publications with INTS6 and Lung Neoplasms
 Prostatic Diseases Antibodies  >1 publications with INTS6 and Prostatic Diseases
 Liver Neoplasms Antibodies  >1 publications with INTS6 and Liver Neoplasms
 Cell Transformation, Neoplastic Antibodies  >1 publications with INTS6 and Cell Transformation, Neoplastic
 Hyperplasia Antibodies  >1 publications with INTS6 and Hyperplasia
 Liver Diseases Antibodies  >1 publications with INTS6 and Liver Diseases

Organs/Tissues associated with INTS6 cdna clone

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >5 publications with INTS6 and Lung
 Prostate Antibodies  >4 publications with INTS6 and Prostate
 Liver Antibodies  >2 publications with INTS6 and Liver
 Muscle Antibodies  >1 publications with INTS6 and Muscle
 Kidney Antibodies  >1 publications with INTS6 and Kidney
 Brain Antibodies  >1 publications with INTS6 and Brain
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