Human ISL1 cDNA Clone Expression Plasmid – Cat# MBS1267254

ISL1 cDNA Clone – ISL LIM Homeobox 1 (Human)

Name: ISL1 cDNA Clone; ISL LIM Homeobox 1; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1267254
Price: 235 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1267254

MBS1267254 is a cDNA clone targeting ISL1. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ISL1, cDNA Clone

Full Product Name

ISL1 cDNA Clone

Product Gene Name

ISL1 cdna clone

Sequence

atgggagaca tgggagatcc accaaaaaaa aaacgtctga tttccctatg tgttggttgc ggcaatcaga ttcacgatca gtatattctg agggtttctc cggatttgga atggcatgcg gcatgtttga aatgtgcgga gtgtaatcag tatttggacg agagctgtac atgctttgtt agggatggga aaacctactg taaaagagat tatatcaggt tgtacgggat caaatgcgcc aagtgcagca tcggcttcag caagaacgac ttcgtgatgc gtgcccgctc caaggtgtat cacatcgagt gtttccgctg tgtggcctgc agccgccagc tcatccctgg ggacgaattt gcgcttcggg aggacggtct cttctgccga gcagaccacg atgtggtgga gagggccagt ctaggcgctg gcgacccgct cagtcccctg catccagcgc ggccactgca aatggcagcg gagcccatct ccgccaggca gccggccctg cggccccacg tccacaagca gccggagaag accacccgcg tgcggactgt gctgaacgag aagcagctgc acaccttgcg gacctgctac gccgcaaacc cgcggccaga tgcgctcatg aaggagcaac tggtagagat gacgggcctc agtccccgtg tgatccgggt ctggtttcaa aacaagcggt gcaaggacaa gaagcgaagc atcatgatga agcaactcca gcagcagcag cccaatgaca aaactaatat ccaggggatg acaggaactc ccatggtggc tgccagtcca gagagacacg acggtggctt acaggctaac ccagtggaag tacaaagtta ccagccacct tggaaagtac tgagcgactt cgccttgcag agtgacatag atcagcctgc ttttcagcaa ctggtcaatt tttcagaagg aggaccgggc tctaattcca ctggcagtga agtagcatca atgtcctctc aacttccaga tacacctaac agcatggtag ccagtcctat tgaggcatga

Molecular Weight

39,036 Da

OMIM

600366

Vector

pENTR223.1 or pUC

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of ISL1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ISL1. It may not necessarily be applicable to this product.

NCBI GI #

22658389

NCBI GeneID

3670

NCBI Accession #

BC031213

UniProt Secondary Accession #

P20663; P47894

UniProt Related Accession #

P61371

NCBI Official Full Name

Homo sapiens ISL LIM homeobox 1, mRNA

NCBI Official Synonym Full Names

ISL LIM homeobox 1

NCBI Official Symbol

ISL1

NCBI Official Synonym Symbols

Isl-1; ISLET1

UniProt Protein Name

Insulin gene enhancer protein ISL-1

Protein Family

Insulin gene enhancer protein

UniProt Gene Name

ISL1

UniProt Synonym Gene Names

Islet-1

UniProt Entry Name

ISL1_HUMAN

NCBI Protein Information

insulin gene enhancer protein ISL-1

NCBI Summary for ISL1

This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young. [provided by RefSeq, Jul 2008]

UniProt Comments for ISL1

ISL1: Binds to one of the cis-acting domain of the insulin gene enhancer.

Protein type: Cell development/differentiation; Transcription factor; Motility/polarity/chemotaxis; DNA-binding; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 5q11.1

Cellular Component: nucleoplasm

Molecular Function: bHLH transcription factor binding; estrogen receptor binding; ligand-dependent nuclear receptor binding; protein binding

Biological Process: mesenchymal cell differentiation; negative regulation of estrogen receptor signaling pathway; negative regulation of inflammatory response; negative regulation of neuron apoptosis; negative regulation of transcription from RNA polymerase II promoter; neuron fate specification; pancreas development; peripheral nervous system neuron axonogenesis; pharyngeal system development; positive regulation of angiogenesis; positive regulation of granulocyte macrophage colony-stimulating factor production; positive regulation of insulin secretion; positive regulation of interferon-gamma production; positive regulation of interleukin-1 alpha production; positive regulation of interleukin-1 beta production; positive regulation of interleukin-12 production; positive regulation of interleukin-6 production; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor production; regulation of transcription from RNA polymerase II promoter; sensory system development; spinal cord motor neuron differentiation; trigeminal nerve development; ventricular cardiac muscle morphogenesis

Research Articles on ISL1

1. Concurrent ISL1/HOXA9 methylation in HG-NMIBC reliably predicted tumour recurrence and progression within one year (Positive Predictive Value 91.7%), and was associated with disease-specific mortality

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with ISL1 cdna clone

Products by Pathway	Pathway Diagram
Cardiac Progenitor Differentiation Pathway antibodies	Cardiac Progenitor Differentiation Pathway Diagram
Heart Development Pathway antibodies	Heart Development Pathway Diagram
Incretin Synthesis, Secretion, And Inactivation Pathway antibodies	Incretin Synthesis, Secretion, And Inactivation Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
Neural Crest Differentiation Pathway antibodies	Neural Crest Differentiation Pathway Diagram
Peptide Hormone Metabolism Pathway antibodies	Peptide Hormone Metabolism Pathway Diagram
Synthesis, Secretion, And Inactivation Of Glucose-dependent Insulinotropic Polypeptide (GIP) Pathway antibodies	Synthesis, Secretion, And Inactivation Of Glucose-dependent Insulinotropic Polypeptide (GIP) Pathway Diagram

Diseases associated with ISL1 cdna clone

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>27 publications with ISL1 and Cardiovascular Diseases
Congenital Abnormalities Antibodies	>20 publications with ISL1 and Congenital Abnormalities
Heart Defects, Congenital Antibodies	>17 publications with ISL1 and Heart Defects, Congenital
Cardiovascular Abnormalities Antibodies	>15 publications with ISL1 and Cardiovascular Abnormalities
Neoplasms Antibodies	>13 publications with ISL1 and Neoplasms
Nervous System Diseases Antibodies	>6 publications with ISL1 and Nervous System Diseases
Fibrosis Antibodies	>4 publications with ISL1 and Fibrosis
Diabetes Mellitus, Type 2 Antibodies	>4 publications with ISL1 and Diabetes Mellitus, Type 2
Neural Tube Defects Antibodies	>3 publications with ISL1 and Neural Tube Defects
Abnormalities, Multiple Antibodies	>2 publications with ISL1 and Abnormalities, Multiple

Organs/Tissues associated with ISL1 cdna clone

Organ/Tissue Name	Pubmed Publications
Embryonic Tissue Antibodies	>94 publications with ISL1 and Embryonic Tissue
Muscle Antibodies	>82 publications with ISL1 and Muscle
Pancreas Antibodies	>54 publications with ISL1 and Pancreas
Brain Antibodies	>38 publications with ISL1 and Brain
Eye Antibodies	>34 publications with ISL1 and Eye
Lung Antibodies	>6 publications with ISL1 and Lung
Stomach Antibodies	>3 publications with ISL1 and Stomach
Kidney Antibodies	>3 publications with ISL1 and Kidney
Umbilical Cord Antibodies	>2 publications with ISL1 and Umbilical Cord
Placenta Antibodies	>1 publications with ISL1 and Placenta