Human JUP cDNA Clone Expression Plasmid – Cat# MBS1268831

JUP cDNA Clone – Junction Plakoglobin (Human)

Name: JUP cDNA Clone; Junction Plakoglobin; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1268831
Price: 235 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1268831

MBS1268831 is a cDNA clone targeting JUP. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

JUP, cDNA Clone

Full Product Name

JUP cDNA Clone

Product Gene Name

JUP cdna clone

Sequence

atggaggtga tgaacctgat ggagcagcct atcaaggtga ctgagtggca gcagacatac acctacgact cgggtatcca ctcgggcgcc aacacctgcg tgccctccgt cagcagcaag ggcatcatgg aggaggatga ggcctgcggg cgccagtaca cgctcaagaa aaccaccact tacacccagg gggtgccccc cagccaaggt gacctggagt accagatgtc cacaacagcc agggccaaac gggtgcggga ggccatgtgc cctggtgtgt caggcgagga cagctcgctt ctgctggcca cccaggtgga ggggcaggcc accaacctgc agcgactggc cgagccgtcc cagctgctca agtcggccat tgtgcatctc atcaactacc aggatgatgc cgagctggcc actcgcgccc tgcccgagct caccaaactg ctcaacgacg aggacccggt ggtggtgacc aaggcggcca tgattgtgaa ccagctgtcg aagaaggagg cgtcgcggcg ggccctgatg ggctcgcccc agctggtggc cgctgtcgtg cgtaccatgc agaataccag cgacctggac acagcccgct gcaccaccag catcctgcac aacctctccc accaccggga ggggctgctc gccatcttca agtcgggtgg catccctgct ctggtccgca tgctcagctc ccctgtggag tcggtcctgt tctatgccat caccacgctg cacaacctgc tcctgtacca ggagggcgcc aagatggccg tgcgcctggc cgacgggctg caaaagatgg tgcccctgct caacaagaac aaccccaagt tcctggccat caccaccgac tgcctgcagc tcctggccta cggcaaccag gagagcaagc tgatcatcct ggccaatggt gggccccagg ccctcgtgca gatcatgcgt aactacagtt atgaaaagct gctctggacc accagtcgtg tgctcaaggt gctatccgtg tgtcccagca ataagcctgc cattgtggag gctggtggga tgcaggccct gggcaagcac ctgaccagca acagcccccg cctggtgcag aactgcctgt ggaccctgcg caacctctca gatgtggcca ccaagcagga gggcctggag agtgtgctga agattctggt gaatcagctg agtgtggatg acgtcaacgt cctcacctgt gccacgggca cactctccaa cctgacatgc aacaacagca agaacaagac gctggtgaca cagaacagcg gtgtggaggc tctcatccat gccatcctgc gtgctggtga caaggacgac atcacggagc ctgccgtctg cgctctgcgc cacctcacta gccgccaccc tgaggccgag atggcccaga actctgtgcg tctcaactat ggcatcccag ccatcgtgaa gctgctcaac cagcccaacc agtggccact ggtcaaggca accatcggct tgatcaggaa tctggccctg tgcccagcca accatgcccc gctgcaggag gcagcggtca tcccccgcct cgtccaactg ctggtgaagg cccaccagga tgcccagcgc cacgtagctg caggcacaca gcagccctac acggatggtg tgaggatgga ggagattgtg gagggctgca ccggagcact gcacatcctc gcccgggacc ccatgaaccg catggagatc ttccggctca acaccattcc cctgtttgtg cagctcctgt actcgtcggt ggagaacatc cagcgcgtgg ctgccggggt gctgtgtgag ctggcccagg acaaggaggc ggccgacgcc attgatgcag agggggcctc ggccccactc atggagttgc tgcactcccg caacgagggc actgccacct acgctgctgc cgtcctgttc cgcatctccg aggacaagaa cccagactac cggaagcgcg tgtccgtgga gctcaccaac tccctcttca agcatgaccc ggctgcctgg gaggctgccc agagcatgat tcccatcaat gagccctatg gagatgactt ggatgccacc taccgcccca tgtactccag cgatgtgccc cttgacccgc tggagatgca catggacatg gatggagact accccatcga cacctacagc gacggcctca ggcccccgta ccccactgca gaccacatgc tggcctag

Molecular Weight

81,745 Da

OMIM

173325

Vector

pENTR223.1

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of JUP cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for JUP. It may not necessarily be applicable to this product.

NCBI GI #

33877720

NCBI GeneID

3728

NCBI Accession #

BC011865

UniProt Secondary Accession #

Q15093; Q15151; Q7L3S5; Q86W21; Q9BWC4; Q9HCX9

UniProt Related Accession #

P14923

NCBI Official Full Name

Homo sapiens junction plakoglobin, mRNA

NCBI Official Synonym Full Names

junction plakoglobin

NCBI Official Symbol

JUP

NCBI Official Synonym Symbols

DP3; PDGB; PKGB; CTNNG; DPIII; ARVD12

UniProt Protein Name

Junction plakoglobin

UniProt Synonym Protein Names

Catenin gamma; Desmoplakin III; Desmoplakin-3

Protein Family

Junction plakoglobin

UniProt Gene Name

JUP

UniProt Synonym Gene Names

CTNNG; DP3

UniProt Entry Name

PLAK_HUMAN

NCBI Protein Information

junction plakoglobin

NCBI Summary for JUP

This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described. [provided by RefSeq, Jul 2008]

UniProt Comments for JUP

CTNNG: Common junctional plaque protein. The membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton. Homodimer. Component of an E-cadherin/ catenin adhesion complex composed of at least E-cadherin/CDH1 and gamma- catenin/JUP, and possibly alpha-catenin/CTNNA1; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Interacts with MUC1. Interacts with CAV1. Interacts with PTPRJ. Interacts with DSC2. Belongs to the beta-catenin family.

Protein type: Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: catenin complex; cell-cell adherens junction; cytoplasm; cytoskeleton; cytosol; desmosome; extracellular matrix; focal adhesion; hemidesmosome; intercellular junction; internal side of plasma membrane; nucleus; plasma membrane; zonula adherens

Molecular Function: alpha-catenin binding; cadherin binding; cell adhesion molecule binding; protein binding; protein homodimerization activity; protein phosphatase binding; structural constituent of cell wall; transcription coactivator activity

Biological Process: cell migration; cell-cell adhesion; detection of mechanical stimulus; positive regulation of protein import into nucleus; positive regulation of transcription factor activity; regulation of cell proliferation

Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 12; Naxos Disease

Research Articles on JUP

1. Idiopathic pulmonary fibrosis lung fibroblasts expressed less Pkgb protein than control fibroblasts, but characteristic fibroblast phenotypes (adhesion, proliferation, and apoptosis) were not controlled by Pkgb expression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with JUP cdna clone

Products by Pathway	Pathway Diagram
Acute Myeloid Leukemia Pathway antibodies	Acute Myeloid Leukemia Pathway Diagram
Acute Myeloid Leukemia Pathway antibodies	Acute Myeloid Leukemia Pathway Diagram
Adherens Junctions Interactions Pathway antibodies	Adherens Junctions Interactions Pathway Diagram
Arf6 Trafficking Events Pathway antibodies	Arf6 Trafficking Events Pathway Diagram
Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies	Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies	Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies	Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
Cell Junction Organization Pathway antibodies	Cell Junction Organization Pathway Diagram
Cell-Cell Communication Pathway antibodies	Cell-Cell Communication Pathway Diagram
Cell-cell Junction Organization Pathway antibodies	Cell-cell Junction Organization Pathway Diagram

Diseases associated with JUP cdna clone

Disease Name	Pubmed Publications
Neoplasms Antibodies	>133 publications with JUP and Neoplasms
Cardiovascular Diseases Antibodies	>36 publications with JUP and Cardiovascular Diseases
Heart Diseases Antibodies	>35 publications with JUP and Heart Diseases
Heart Defects, Congenital Antibodies	>25 publications with JUP and Heart Defects, Congenital
Breast Neoplasms Antibodies	>18 publications with JUP and Breast Neoplasms
Lung Diseases Antibodies	>14 publications with JUP and Lung Diseases
Kidney Diseases Antibodies	>10 publications with JUP and Kidney Diseases
Cell Transformation, Neoplastic Antibodies	>9 publications with JUP and Cell Transformation, Neoplastic
Immune System Diseases Antibodies	>8 publications with JUP and Immune System Diseases
Liver Neoplasms Antibodies	>7 publications with JUP and Liver Neoplasms

Organs/Tissues associated with JUP cdna clone

Organ/Tissue Name	Pubmed Publications
Heart Antibodies	>35 publications with JUP and Heart
Skin Antibodies	>26 publications with JUP and Skin
Lung Antibodies	>22 publications with JUP and Lung
Muscle Antibodies	>18 publications with JUP and Muscle
Lymph Antibodies	>17 publications with JUP and Lymph
Lymph Node Antibodies	>17 publications with JUP and Lymph Node
Blood Antibodies	>16 publications with JUP and Blood
Kidney Antibodies	>12 publications with JUP and Kidney
Mouth Antibodies	>10 publications with JUP and Mouth
Bladder Antibodies	>9 publications with JUP and Bladder