Human KARS cDNA Clone Expression Plasmid – Cat# MBS1266409

KARS cDNA Clone – Lysyl-Trna Synthetase (Human)

Name: KARS cDNA Clone; Lysyl-Trna Synthetase; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1266409
Price: 400 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1266409

MBS1266409 is a cDNA clone targeting KARS. More details

$400 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

KARS, cDNA Clone

Full Product Name

KARS cDNA Clone

Product Gene Name

KARS cdna clone

Sequence

atggcggccg tgcaggcggc cgaggtgaaa gtggatggca gcgagccgaa actgagcaag aatgagctga agagacgcct gaaagctgag aagaaagtag cagagaagga ggccaaacag aaggagctca gtgagaaaca gctaagccaa gccactgctg ctgccaccaa ccacaccact gataatggtg tgggtcctga ggaagagagc gtggacccaa atcaatacta caaaatccgc agtcaagcaa ttcatcagct gaaggtcaat ggggaagacc catacccaca caagttccat gtagacatct cactcactga cttcatccaa aaatatagtc acctgcagcc tggggatcac ctgactgaca tcaccttaaa ggtggcaggt aggatccatg ccaaaagagc ttctggggga aagctcatct tctatgatct tcgaggagag ggggtgaagt tgcaagtcat ggccaattcc agaaattata aatcagaaga agaatttatt catattaata acaaactgcg tcggggagac ataattggag ttcaggggaa tcctggtaaa accaagaagg gtgagctgag catcattccg tatgagatca cactgctgtc tccctgtttg catatgttac ctcatcttca ctttggcctc aaagacaagg aaacaaggta tcgccagaga tacttggact tgatcctgaa tgactttgtg aggcagaaat ttatcatccg ctctaagatc atcacatata taagaagttt cttagatgag ctgggattcc tagagattga aactcccatg atgaacatca tcccaggggg agccgtggcc aagcctttca tcacttatca caacgagctg gacatgaact tatatatgag aattgctcca gaactctatc ataagatgct tgtggttggt ggcatcgacc gggtttatga aattggacgc cagttccgga atgaggggat tgatttgacg cacaatcctg agttcaccac ctgtgagttc tacatggcct atgcagacta tcacgatctc atggaaatca cggagaagat ggtttcaggg atggtgaagc atattacagg cagttacaag gtcacctacc acccagatgg cccagagggc caagcctacg atgttgactt caccccaccc ttccggcgaa tcaacatggt agaagagctt gagaaagccc tggggatgaa gctgccagaa acgaacctct ttgaaactga agaaactcgc aaaattcttg atgatatctg tgtggcaaaa gctgttgaat gccctccacc tcggaccaca gccaggctcc ttgacaagct tgttggggag ttcctggaag tgacttgcat caatcctaca ttcatctgtg atcacccaca gataatgagc cctttggcta aatggcaccg ctctaaagag ggtctgactg agcgctttga gctgtttgtc atgaagaaag agatatgcaa tgcgtatact gagctgaatg atcccatgcg gcagcggcag ctttttgaag aacaggccaa ggccaaggct gcaggtgatg atgaggccat gttcatagat gaaaacttct gtactgccct ggaatatggg ctgcccccca cagctggctg gggcatgggc attgatcgag tcgccatgtt tctcacggac tccaacaaca tcaaggaagt acttctgttt cctgccatga aacccgaaga caagaaggag aatgtagcaa ccactgatac actggaaagc acaacagttg gcacttctgt ctag

Molecular Weight

71,497 Da

OMIM

601421

Vector

pENTR223.1

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of KARS cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for KARS. It may not necessarily be applicable to this product.

NCBI GI #

34782788

NCBI GeneID

3735

NCBI Accession #

BC004132

UniProt Secondary Accession #

O14946; Q96J25; Q9HB23; A8MSK1; D3DUK4

UniProt Related Accession #

Q15046

NCBI Official Full Name

Homo sapiens lysyl-tRNA synthetase, mRNA

NCBI Official Synonym Full Names

lysyl-tRNA synthetase

NCBI Official Symbol

KARS

NCBI Official Synonym Symbols

KRS; KARS1; KARS2; CMTRIB; DFNB89

UniProt Protein Name

Lysine--tRNA ligase

UniProt Synonym Protein Names

Lysyl-tRNA synthetase; LysRS

UniProt Gene Name

KARS

UniProt Synonym Gene Names

KIAA0070; LysRS

UniProt Entry Name

SYK_HUMAN

NCBI Protein Information

lysine--tRNA ligase

NCBI Summary for KARS

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

UniProt Comments for KARS

KARS: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of diadenosine oligophosphate (Ap4A), a signaling molecule involved in the activation of MITF transcriptional activity. Interacts with HIV-1 virus GAG protein, facilitating the selective packaging of tRNA(3)(Lys), the primer for reverse transcription initiation. Homodimer; also part of a multisubunit complex that groups AIMP1, AIMP2, EEF1A1 and tRNA ligases for Arg, Asp, Glu, Gln, Ile, Leu, Lys, Met and Pro. Interacts with AIMP2 (via N- terminus) and MITF. Interacts directly with HIV-1 virus GAG protein. Up-regulated by DARS and EEF1A1, but not by AIMP2. Belongs to the class-II aminoacyl-tRNA synthetase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Translation; Mitochondrial; Ligase; EC 6.1.1.6

Chromosomal Location of Human Ortholog: 16q23.1

Cellular Component: cytoplasm; cytosol; microtubule cytoskeleton; mitochondrial matrix; mitochondrion

Molecular Function: lysine-tRNA ligase activity; protein binding

Biological Process: lysyl-tRNA aminoacylation; tRNA aminoacylation for protein translation

Disease: Charcot-marie-tooth Disease, Recessive Intermediate B; Deafness, Autosomal Recessive 89

Research Articles on KARS

1. KRS at the plasma membrane plays new roles in metastatic migration as a signaling inducer, and causes intracellular signaling for cancer dissemination

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with KARS cdna clone

Products by Pathway	Pathway Diagram
Aminoacyl-tRNA Biosynthesis Pathway antibodies	Aminoacyl-tRNA Biosynthesis Pathway Diagram
Aminoacyl-tRNA Biosynthesis Pathway antibodies	Aminoacyl-tRNA Biosynthesis Pathway Diagram
Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway antibodies	Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway Diagram
Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway antibodies	Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway Diagram
Cytosolic TRNA Aminoacylation Pathway antibodies	Cytosolic TRNA Aminoacylation Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
Mitochondrial TRNA Aminoacylation Pathway antibodies	Mitochondrial TRNA Aminoacylation Pathway Diagram
TRNA Aminoacylation Pathway antibodies	TRNA Aminoacylation Pathway Diagram

Diseases associated with KARS cdna clone

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>48 publications with KARS and Cardiovascular Diseases
Bone Diseases Antibodies	>19 publications with KARS and Bone Diseases
Kidney Diseases Antibodies	>12 publications with KARS and Kidney Diseases
Necrosis Antibodies	>12 publications with KARS and Necrosis
Adenocarcinoma Antibodies	>11 publications with KARS and Adenocarcinoma
Liver Neoplasms Antibodies	>7 publications with KARS and Liver Neoplasms
Hyperplasia Antibodies	>7 publications with KARS and Hyperplasia
Stroke Antibodies	>6 publications with KARS and Stroke
Inflammation Antibodies	>5 publications with KARS and Inflammation
Gonadal Disorders Antibodies	>5 publications with KARS and Gonadal Disorders

Organs/Tissues associated with KARS cdna clone

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>129 publications with KARS and Brain
Blood Antibodies	>128 publications with KARS and Blood
Vascular Antibodies	>35 publications with KARS and Vascular
Bone Antibodies	>34 publications with KARS and Bone
Liver Antibodies	>34 publications with KARS and Liver
Lung Antibodies	>30 publications with KARS and Lung
Nerve Antibodies	>26 publications with KARS and Nerve
Heart Antibodies	>22 publications with KARS and Heart
Kidney Antibodies	>21 publications with KARS and Kidney
Muscle Antibodies	>14 publications with KARS and Muscle