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KRT17 cDNA Clone – Keratin, Type I Cytoskeletal 17

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS200659

KRT17 encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in KRT17 lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. More details

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Product Overview

Online Datasheet in PDF
Product Name
KRT17, cDNA Clone
Full Product Name
KRT17
Product Gene Name
KRT17 cdna clone
Product Synonym Names
K17; PC; PC2; PCHC1
Sequence
Nucleotide Sequence: ATGACCACCT CCATCCGCCA GTTCACCTCC TCCAGCTCCA TCAAGGGCTC CTCCGGCCTG GGGGGCGGCT CGTCCCGCAC CTCCTGCCGG CTGTCTGGCG GCCTGGGTGC CGGCTCCTGC AGGCTGGGAT CTGCTGGCGG CCTGGGCAGC ACCCTCGGGG GTAGCAGCTA CTCCAGCTGC TACAGCTTTG GCTCTGGTGG TGGCTATGGC AGCAGCTTTG GGGGTGTTGA TGGGCTGCTG GCTGGAGGTG AGAAGGCCAC CATGCAGAAC CTCAATGACC GCCTGGCCTC CTACCTGGAC AAGGTGCGTG CCCTGGAGGA GGCCAACACT GAGCTGGAGG TGAAGATCCG TGACTGGTAC CAGAGGCAGG CCCCGGGGCC CGCCCGTGAC TACAGCCAGT ACTACAGGAC AATTGAGGAG CTGCAGAACA AGATCCTCAC AGCCACCGTG GACAATGCCA ACATCCTGCT ACAGATTGAC AATGCCCGTC TGGCTGCTGA TGACTTCCGC ACCAAGTTTG AGACAGAGCA GGCCCTGCGC CTGAGTGTGG AGGCCGACAT CAATGGCCTG CGCAGGGTGC TGGATGAGCT GACCCTGGCC AGAGCCGACC TGGAGATGCA GATTGAGAAC CTCAAGGAGG AGCTGGCCTA CCTGAAGAAG AACCACGAGG AGGAGATGAA CGCCCTGCGA GGCCAGGTGG GTGGTGAGAT CAATGTGGAG ATGGACGCTG CCCCAGGCGT GGACCTGAGC CGCATCCTCA ACGAGATGCG TGACCAGTAT GAGAAGATGG CAGAGAAGAA CCGCAAGGAT GCCGAGGATT GGTTCTTCAG CAAGACAGAG GAACTGAACC GCGAGGTGGC CACCAACAGT GAGCTGGTGC AGAGTGGCAA GAGTGAGATC TCGGAGCTCC GGCGCACCAT GCAGGCCTTG GAGATAGAGC TGCAGTCCCA GCTCAGCATG AAAGCATCCC TGGAGGGCAA CCTGGCGGAG ACAGAGAACC GCTACTGCGT GCAGCTGTCC CAGATCCAGG GGCTGATTGG CAGCGTGGAG GAGCAGCTGG CCCAGCTTCG CTGCGAGATG GAGCAGCAGA ACCAGGAATA CAAAATCCTG CTGGATGTGA AGACGCGGCT GGAGCAGGAG ATTGCCACCT ACCGCCGCCT GCTGGAGGGA GAGGATGCCC ACCTGACTCA GTACAAGAAA GAACCGGTGA CCACCCGTCA GGTGCGTACC ATTGTGGAAG AGGTCCAGGA TGGCAAGGTC ATCTCCTCCC GCGAGCAGGT CCACCAGACC ACCCGCTGA< br>
Tra nslation Sequence: MTTSIRQFTS SSSIKGSSGL GGGSSRTSCR LSGGLGAGSC RLGSAGGLGS TLGGSSYSSC YSFGSGGGYG SSFGGVDGLL AGGEKATMQN LNDRLASYLD KVRALEEANT ELEVKIRDWY QRQAPGPARD YSQYYRTIEE LQNKILTATV DNANILLQID NARLAADDFR TKFETEQALR LSVEADINGL RRVLDELTLA RADLEMQIEN LKEELAYLKK NHEEEMNALR GQVGGEINVE MDAAPGVDLS RILNEMRDQY EKMAEKNRKD AEDWFFSKTE ELNREVATNS ELVQSGKSEI SELRRTMQAL EIELQSQLSM KASLEGNLAE TENRYCVQLS QIQGLIGSVE EQLAQLRCEM EQQNQEYKIL LDVKTRLEQE IATYRRLLEG EDAHLTQYKK EPVTTRQVRT IVEEVQDGKV ISSREQVHQT TR
Form/Format
Lyophilized
Preparation and Storage
Store the plasmid at -20 degree C.
OMIM
148069
3D Structure
ModBase 3D Structure for Q04695
Species
Human
Chromosome Location
17q21.2
OMIM Reference Number
148069
cDNA Size
1299bp
Vector Description
This shuttle vector contains the complete ORF. It is inseted BamH I to Xho I. The gene insert contains multiple cloning sites which can be used to easily cut and transfer the gene and recombination site into your expression vector.
Vector
(puc19-derived cloning vector)
Preparation Before Usage
1. Centrifuge at 7000rpm for 1 minute. 2. Carefully open the vial and add 100ul of sterile water to dissolve the DNA. Each tube contains approximately 10ug of lyophilized plasmid.

Product Categories/Family for KRT17 cdna clone

Signal Transduction

Other Notes

Small volumes of KRT17 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KRT17 purchase

MBS200659 is a cDNA clone targeting KRT17.

Additional Details

NCBI/Uniprot data below describe general gene information for KRT17. It may not necessarily be applicable to this product.

NCBI GI #
4557701
NCBI GeneID
3872
NCBI Accession #
NP_000413.1
UniProt Primary Accession #
Q04695
UniProt Related Accession #
Q04695
GenBank Nucleotide #
NM_000422.2
NCBI Official Full Name
keratin, type I cytoskeletal 17
NCBI Official Synonym Full Names
keratin 17
NCBI Official Symbol
KRT17
NCBI Official Synonym Symbols
PC; K17; PC2; 39.1; CK-17; PCHC1
UniProt Protein Name
Keratin, type I cytoskeletal 17
UniProt Synonym Protein Names
39.1; Cytokeratin-17; CK-17; Keratin-17
Protein Family
Keratin
UniProt Gene Name
KRT17
UniProt Synonym Gene Names
CK-17; K17
UniProt Entry Name
K1C17_HUMAN
NCBI Protein Information
keratin, type I cytoskeletal 17

NCBI Summary for KRT17

This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. [provided by RefSeq, Aug 2008]

UniProt Comments for KRT17

K17: a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K6.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 17q21.2

Cellular Component: cytoplasm; intermediate filament

Molecular Function: MHC class II receptor activity; protein binding; structural constituent of cytoskeleton; MHC class II protein binding

Biological Process: positive regulation of hair follicle development; epidermis development; hair follicle morphogenesis; positive regulation of translation; keratinization; intermediate filament organization; signal transduction; positive regulation of cell growth

Disease: Steatocystoma Multiplex; Pachyonychia Congenita 2
Show more

Research Articles on KRT17

1. High KRT17 expression is associated with paclitaxel-induced resistance and migration in cervical cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with KRT17 cdna clone

 Reference Product  PubMed Publications
 KRT6A cdna clone  >17 publications with KRT17 and KRT6A
 KRT7 cdna clone  >1 publications with KRT17 and KRT7

Pathways associated with KRT17 cdna clone

 Products by Pathway  Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Glucocorticoid Receptor Regulatory Network Pathway antibodies  Glucocorticoid Receptor Regulatory Network Pathway Diagram

Diseases associated with KRT17 cdna clone

 Disease Name  Pubmed Publications
 Pachyonychia congenita Jackson Lawler type Antibodies  >20 publications with KRT17 and Pachyonychia congenita Jackson Lawler type
 Neoplasms Antibodies  >19 publications with KRT17 and Neoplasms
 Adenocarcinoma Antibodies  >7 publications with KRT17 and Adenocarcinoma
 Carcinoma, Squamous Cell Antibodies  >7 publications with KRT17 and Carcinoma, Squamous Cell
 Breast Neoplasms Antibodies  >5 publications with KRT17 and Breast Neoplasms
 Pain Antibodies  >4 publications with KRT17 and Pain
 Skin Neoplasms Antibodies  >3 publications with KRT17 and Skin Neoplasms
 Carcinoma, Basal Cell Antibodies  >2 publications with KRT17 and Carcinoma, Basal Cell
 Esophageal Squamous Cell Carcinoma Antibodies  >2 publications with KRT17 and Esophageal Squamous Cell Carcinoma
 Precancerous Conditions Antibodies  >1 publications with KRT17 and Precancerous Conditions

Organs/Tissues associated with KRT17 cdna clone

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >16 publications with KRT17 and Skin
 Mouth Antibodies  >3 publications with KRT17 and Mouth
 Lymph Antibodies  >2 publications with KRT17 and Lymph
 Mammary Gland Antibodies  >2 publications with KRT17 and Mammary Gland
 Lymph Node Antibodies  >2 publications with KRT17 and Lymph Node
 Intestine Antibodies  >1 publications with KRT17 and Intestine
 Bladder Antibodies  >1 publications with KRT17 and Bladder
 Prostate Antibodies  >1 publications with KRT17 and Prostate
 Muscle Antibodies  >1 publications with KRT17 and Muscle
 Pancreas Antibodies  >1 publications with KRT17 and Pancreas
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