Human LECT1 cDNA Clone Expression Plasmid – Cat# MBS1270068

LECT1 cDNA Clone – Leukocyte Cell Derived Chemotaxin 1 (Human)

Name: LECT1 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1270068
Price: 235 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1270068

MBS1270068 is a cDNA clone targeting LECT1. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

LECT1, cDNA Clone

Full Product Name

LECT1 cDNA Clone

Product Gene Name

LECT1 cdna clone

Sequence

atgacagaga actccgacaa agttcccatt gccctggtgg gacctgatga cgtggaattc tgcagccccc cggcgtacgc tacgctgacg gtgaagccct ccagccccgc gcggctgctc aaggtgggag ccgtggtcct catttcggga gctgtgctgc tgctctttgg ggccatcggg gccttctact tctggaaggg gagcgacagt cacatttaca atgtccatta caccatgagt atcaatggga aattacaaga tgggtcaatg gaaatagacg ctgggaacaa cttggagacc tttaaaatgg gaagtggagc tgaagaagca attgcagtta atgatttcca gaatggcatc acaggaattc gttttgctgg aggagagaag tgctacatta aagcgcaagt gaaggctcgt attcctgagg tgggcgccgt gaccaaacag agcatctcct ccaaactgga aggcaagatc atgccagtca aatatgaaga aaattctctt atctgggtgg ctgtagatca gcctgtgaag gacaacagct tcttgagttc taaggtgtta gaactctgcg gtgaccttcc tattttctgg cttaaaccaa cctatccaaa agaaatccag agggaaagaa gagaagtggt aagaaaaatt gttccaacta ccacaaaaag accacacagt ggaccacgga gcaacccagg cgctggaaga ctgaataatg aaaccagacc cagtgttcaa gaggactcac aagccttcaa tcctgataat ccttatcatc aggaagggga aagcatgaca ttcgacccta gactggatca cgaaggaatc tgttgtatag aatgtaggcg gagctacacc cactgccaga agatctgtga acccctgggg ggctattacc catggcctta taattatcaa ggctgccgtt cggcctgcag agtcatcatg ccatgtagct ggtgggtggc ccgtatcttg ggcatggtgt ga

Molecular Weight

36,974 Da

OMIM

605147

Vector

pENTR223.1

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of LECT1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for LECT1. It may not necessarily be applicable to this product.

NCBI GI #

19343688

NCBI GeneID

11061

NCBI Accession #

BC025659

UniProt Secondary Accession #

Q5TAM4; Q8TAY6; Q9UM18

UniProt Related Accession #

O75829

NCBI Official Full Name

Homo sapiens leukocyte cell derived chemotaxin 1, mRNA

NCBI Official Synonym Full Names

leukocyte cell derived chemotaxin 1

NCBI Official Symbol

LECT1

NCBI Official Synonym Symbols

CHM1; CHM-I; BRICD3; MYETS1

UniProt Protein Name

Leukocyte cell-derived chemotaxin 1

UniProt Synonym Protein Names

Chondrosurfactant protein; CH-SP

Protein Family

Leukocyte cell-derived chemotaxin

UniProt Gene Name

LECT1

UniProt Synonym Gene Names

CHMI; CH-SP; ChM-I

UniProt Entry Name

LECT1_HUMAN

NCBI Protein Information

leukocyte cell-derived chemotaxin 1

NCBI Summary for LECT1

This gene encodes a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This gene is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularization during development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

UniProt Comments for LECT1

LECT1: Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development. Inhibits in vitro tube formation and mobilization of endothelial cells. Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization. Belongs to the chondromodulin-1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell development/differentiation; Membrane protein, integral

Chromosomal Location of Human Ortholog: 13q14.3

Biological Process: negative regulation of angiogenesis; proteoglycan metabolic process; skeletal development

Research Articles on LECT1

1. Data suggest ChM1 as potential tumor suppressor in gastric cancer and useful biomarker for the treatment and prognosis. Its expression was downregulated in cancer tissue, and correlated with advanced stages, lymph node metastasis, and poorer prognosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with LECT1 cdna clone

Disease Name	Pubmed Publications
Neoplasms Antibodies	>16 publications with LECT1 and Neoplasms
Congenital Abnormalities Antibodies	>4 publications with LECT1 and Congenital Abnormalities
Atherosclerosis Antibodies	>3 publications with LECT1 and Atherosclerosis
Liver Diseases Antibodies	>3 publications with LECT1 and Liver Diseases
Brain Diseases Antibodies	>2 publications with LECT1 and Brain Diseases
Nervous System Diseases Antibodies	>2 publications with LECT1 and Nervous System Diseases
Drug Toxicity Antibodies	>2 publications with LECT1 and Drug Toxicity
Carcinoma Antibodies	>2 publications with LECT1 and Carcinoma
Hypertrophy Antibodies	>2 publications with LECT1 and Hypertrophy
Carcinoma, Hepatocellular Antibodies	>1 publications with LECT1 and Carcinoma, Hepatocellular

Organs/Tissues associated with LECT1 cdna clone

Organ/Tissue Name	Pubmed Publications
Bone Antibodies	>37 publications with LECT1 and Bone
Connective Tissue Antibodies	>29 publications with LECT1 and Connective Tissue
Embryonic Tissue Antibodies	>10 publications with LECT1 and Embryonic Tissue
Eye Antibodies	>8 publications with LECT1 and Eye
Lung Antibodies	>2 publications with LECT1 and Lung
Ear Antibodies	>1 publications with LECT1 and Ear
Brain Antibodies	>1 publications with LECT1 and Brain