Human LIPE cDNA Clone Expression Plasmid – Cat# MBS1267027

LIPE cDNA Clone – Lipase, Hormone-Sensitive (Human)

Name: LIPE cDNA Clone; Lipase, Hormone-Sensitive; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1267027
Price: 1355 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1267027

MBS1267027 is a cDNA clone targeting LIPE. More details

$1355 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

LIPE, cDNA Clone

Full Product Name

LIPE cDNA Clone

Product Gene Name

LIPE cdna clone

Sequence

atggagccag gttctaagtc agtgtctagg tcagactggc aacctgaacc acaccagagg cctataaccc cgctagagcc tgggccagaa aagacaccca tagcccagcc agaatcgaag actctgcagg gatccaatac ccaacagaag cctgcttcaa accaaagacc cctcacccag caggagaccc ctgcacaaca tgatgctgaa tcccagaagg aacctagagc ccaacaaaaa tctgcttcac aagaggaatt tcttgcccca cagaagcccg caccacagca atcaccttac atccaaaggg tgctgctcac tcaacaggaa gctgcctccc agcagggacc tgggctagga aaagaatcta taactcaaca ggagccagca ttgagacaaa gacatgtagc ccagccaggg cctgggccag gagagccacc tccagctcaa caagaagctg aatcaacacc tgcggcccag gctaaacctg gagccaaaag ggagccatct gccccgactg aatctacgtc ccaagagaca cctgaacagt cagacaagca aacaacgcca gtccagggag ccaaatccaa gcagggatct ttgacagagc tgggatttct aacaaaactt caggaactat ccatacagcg atcagcccta gagtggaagg cactttctga gtgggtcaca gattctgagt cagaatcaga tgtgggatca tcttcagaca cagattctcc agccacgatg ggtggaatgg tggcccaggg agtgaagcta ggcttcaaag gaaaatctgg ttataaagtg atgtcaggat acagtgggac gtcgccacat gagaaaacca gtgctcggaa tcacagacac taccaggata cagcctcaag gctcatccac aacatggacc tgcgcacaat gacacagtcg ctggtgactc tggcggagga caacatagcc ttcttctcga gccagggtcc tggggaaacg gcccagcggc tgtcaggcgt ttttgccggt gtacgggagc aggcgctggg gctggagccg gccctgggcc gcctgctggg tgtggcgcac ctctttgacc tggacccaga gacaccggcc aacgggtacc gcagcctagt gcacacagcc cgctgctgcc tggcgcacct cctgcacaaa tcccgctatg tggcctccaa ccgccgcagc atcttcttcc gcaccagcca caacctggcc gagctggagg cctacctggc tgccctcacc cagctccgcg ctctggtcta ctacgcccag cgcctgctgg ttaccaatcg gccgggggta ctcttctttg agggcgacga ggggctcacc gccgacttcc tccgggagta tgtcacgctg cataagggat gcttctatgg ccgctgcctg ggcttccagt tcacgcctgc catccggcca ttcctgcaga ccatctacat tgggctggtg tccttcgggg agcactacaa acgcaacgag acaggcctca gtgtggccgc cagctctctc ttcaccagcg gccgctttgc catcgacccc gagctgcgtg gggctgagtt tgagcggatc acacagaacc tggacgtgca cttctggaaa gccttctgga acatcaccga gatggaagtg ctatcgtctc tggccaacat ggcatcggcc accgtgaggg taagccgcct gctcagcctg ccacccgaag cctttgagat gccactgact gccgacccca cgctcacggt caccatctca cccccactgg cccacacagg ccctgggccc gtcctcgtca ggctcatctc ctgtgacctg cgtgaaggac aggacagtga ggagctcagc agcctgataa agtccaacgg ccaacggagc ctggagctgt ggccgcgccc ccagcaggca ccccgctcgc ggtccctgat agtgcacttc cacggcggtg gctttgtggc ccagacctcc agatcccacg agccctacct caagagctgg gcccaggagc tgggcgcccc catcatctcc atcgactact ccctggcccc tgaggccccc ttcccccgtg cgctggagga gtgcttcttc gcctactgct gggccatcaa gcactgcgcc ctccttggct caacagggga acgaatctgc cttgcggggg acagtgcagg cgggaacctc tgcttcaccg tggctcttcg ggcagcagcc tacggggtgc gggtgccaga tggcatcatg gcagcctacc cggccacaat gctgcagcct gccgcctctc cctcccgcct gctgagcctc atggacccct tgctgcccct cagtgtgctc tccaagtgtg tcagcgccta tgctggtgca aagacggagg accactccaa ctcagaccag aaagccctcg gcatgatggg gctggtgcgg cgggacacag ccctgctcct ccgagacttc cgcctgggtg cctcctcatg gctcaactcc ttcctggagt taagtgggcg caagtcccag aagatgtcgg agcccatagc agagccgatg cgccgcagtg tgtctgaagc agcactggcc cagccccagg gcccactggg cacggattcc ctcaagaacc tgaccctgag ggacttgagc ctgaggggaa actccgagac gtcgtcggac acccccgaga tgtcgctgtc agctgagaca cttagcccct ccacaccctc cgatgtcaac ttcttattac cacctgagga tgcaggggaa gaggctgagg ccaaaaatga gctgagcccc atggacagag gcctgggcgt ccgtgccgcc ttccccgagg gtttccaccc ccgacgctcc agccagggtg ccacacagat gcccctctac tcctcaccca tagtcaagaa ccccttcatg tcgccgctgc tggcacccga cagcatgctc aagagcctgc cacctgtgca catcgtggcg tgcgcgctgg accccatgct ggacgactcg gtcatgctcg cgcggcgact gcgcaacctg ggccagccgg tgacgctgcg cgtggtggag gacctgccgc acggcttcct gaccctagcg gcgctgtgcc gcgagacgcg ccaggccgca gagctgtgcg tggagcgcat ccgcctcgtc ctcactcctc ccgccggagc cgggccgagc ggggagacgg gggctgcggg ggtagacggg ggctgcgggg ggcgacacta a

Molecular Weight

84,128 Da

OMIM

151750

Vector

Please Inquire

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of LIPE cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for LIPE. It may not necessarily be applicable to this product.

NCBI GI #

47124455

NCBI GeneID

3991

NCBI Accession #

BC070041

UniProt Secondary Accession #

Q3LRT2; Q6NSL7

UniProt Related Accession #

Q05469

NCBI Official Full Name

Homo sapiens lipase, hormone-sensitive, mRNA

NCBI Official Synonym Full Names

lipase E, hormone sensitive type

NCBI Official Symbol

LIPE

NCBI Official Synonym Symbols

HSL; LHS; AOMS4; FPLD6

UniProt Protein Name

Hormone-sensitive lipase

Protein Family

Hormone-sensitive lipase

UniProt Gene Name

LIPE

UniProt Synonym Gene Names

HSL

UniProt Entry Name

LIPS_HUMAN

NCBI Protein Information

hormone-sensitive lipase

NCBI Summary for LIPE

The protein encoded by this gene has a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids. [provided by RefSeq, Jul 2008]

UniProt Comments for LIPE

HSL: hormone sensitive lipase is a lipolytic enzyme of the 'GDXG' family. Plays a rate limiting step in triglyceride lipolysis. In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production. Rapidly activated by cAMP-dependent phosphorylation under the influence of catecholamines. Dephosphorylation and inactivation are controlled by insulin.

Protein type: Lipase; EC 3.1.1.79

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: lipid particle

Molecular Function: protein binding

Biological Process: lipid catabolic process; protein amino acid phosphorylation

Disease: Abdominal Obesity-metabolic Syndrome 4

Research Articles on LIPE

1. Despite reductions in intramyocellular lipolysis and HSL expression, overexpression of HSL did not rescue defects in insulin action in skeletal myotubes from obese type 2 diabetic subjects.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with LIPE cdna clone

Products by Pathway	Pathway Diagram
AMPK Signaling Pathway antibodies	AMPK Signaling Pathway Diagram
Adipogenesis Pathway antibodies	Adipogenesis Pathway Diagram
Fatty Acid Beta Oxidation Pathway antibodies	Fatty Acid Beta Oxidation Pathway Diagram
Hormone-sensitive Lipase (HSL)-mediated Triacylglycerol Hydrolysis Pathway antibodies	Hormone-sensitive Lipase (HSL)-mediated Triacylglycerol Hydrolysis Pathway Diagram
Insulin Signaling Pathway antibodies	Insulin Signaling Pathway Diagram
Insulin Signaling Pathway antibodies	Insulin Signaling Pathway Diagram
Insulin Signaling Pathway antibodies	Insulin Signaling Pathway Diagram
Lipid Digestion, Mobilization, And Transport Pathway antibodies	Lipid Digestion, Mobilization, And Transport Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Lipids And Lipoproteins Pathway antibodies	Metabolism Of Lipids And Lipoproteins Pathway Diagram

Diseases associated with LIPE cdna clone

Disease Name	Pubmed Publications
Obesity Antibodies	>19 publications with LIPE and Obesity
Insulin Resistance Antibodies	>11 publications with LIPE and Insulin Resistance
Cardiovascular Diseases Antibodies	>11 publications with LIPE and Cardiovascular Diseases
Drug Toxicity Antibodies	>8 publications with LIPE and Drug Toxicity
Atherosclerosis Antibodies	>6 publications with LIPE and Atherosclerosis
Muscular Diseases Antibodies	>6 publications with LIPE and Muscular Diseases
Hypertension Antibodies	>4 publications with LIPE and Hypertension
Weight Gain Antibodies	>4 publications with LIPE and Weight Gain
Fatty Liver Antibodies	>3 publications with LIPE and Fatty Liver
Diabetes Mellitus Antibodies	>3 publications with LIPE and Diabetes Mellitus

Organs/Tissues associated with LIPE cdna clone

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>37 publications with LIPE and Blood
Brain Antibodies	>29 publications with LIPE and Brain
Adipose Tissue Antibodies	>19 publications with LIPE and Adipose Tissue
Kidney Antibodies	>6 publications with LIPE and Kidney
Lung Antibodies	>5 publications with LIPE and Lung
Placenta Antibodies	>4 publications with LIPE and Placenta
Embryonic Tissue Antibodies	>4 publications with LIPE and Embryonic Tissue
Eye Antibodies	>3 publications with LIPE and Eye
Adrenal Gland Antibodies	>3 publications with LIPE and Adrenal Gland
Bone Antibodies	>3 publications with LIPE and Bone