Human LMNA cDNA Clone Expression Plasmid – Cat# MBS1267346

LMNA cDNA Clone – Lamin A/C (Human)

Name: LMNA cDNA Clone; Lamin A/C; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1267346
Price: 755 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1267346

MBS1267346 is a cDNA clone targeting LMNA. More details

$755 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

LMNA, cDNA Clone

Full Product Name

LMNA cDNA Clone

Product Gene Name

LMNA cdna clone

Sequence

atggagaccc cgtcccagcg gcgcgccacc cgcagcgggg cgcaggccag ctccactccg ctgtcgccca cccgcatcac ccggctgcag gagaaggagg acctgcagga gctcaatgat cgcttggcgg tctacatcga ccgtgtgcgc tcgctggaaa cggagaacgc agggctgcgc cttcgcatca ccgagtctga agaggtggtc agccgcgagg tgtccggcat caaggccgcc tacgaggccg agctcgggga tgcccgcaag acccttgact cagtagccaa ggagcgcgcc cgcctgcagc tggagctgag caaagtgcgt gaggagttta aggagctgaa agcgcgcaat accaagaagg agggtgacct gatagctgct caggctcggc tgaaggacct ggaggctctg ctgaactcca aggaggccgc actgagcact gctctcagtg agaagcgcac gctggagggc gagctgcatg atctgcgggg ccaggtggcc aagcttgagg cagccctagg tgaggccaag aagcaacttc aggatgagat gctgcggcgg gtggatgctg agaacaggct gcagaccatg aaggaggaac tggacttcca gaagaacatc tacagtgagg agctgcgtga gaccaagcgc cgtcatgaga cccgactggt ggagattgac aatgggaagc agcgtgagtt tgagagccgg ctggcggatg cgctgcagga actgcgggcc cagcatgagg accaggtgga gcagtataag aaggagctgg agaagactta ttctgccaag ctggacaatg ccaggcagtc tgctgagagg aacagcaacc tggtgggggc tgcccacgag gagctgcagc agtcgcgcat ccgcatcgac agcctctctg cccagctcag ccagctccag aagcagctgg cagccaagga ggcgaagctt cgagacctgg aggactcact ggcccgtgag cgggacacca gccggcggct gctggcggaa aaggagcggg agatggccga gatgcgggca aggatgcagc agcagctgga cgagtaccag gagcttctgg acatcaagct ggccctggac atggagatcc acgcctaccg caagctcttg gagggcgagg aggagaggct acgcctgtcc cccagcccta cctcgcagcg cagccgtggc cgtgcttcct ctcactcatc ccagacacag ggtgggggca gcgtcaccaa aaagcgcaaa ctggagtcca ctgagagccg cagcagcttc tcacagcacg cacgcactag cgggcgcgtg gccgtggagg aggtggatga ggagggcaag tttgtccggc tgcgcaacaa gtccaatgag gaccagtcca tgggcaattg gcagatcaag cgccagaatg gagatgatcc cttgctgact taccggttcc caccaaagtt caccctgaag gctgggcagg tggtgacgat ctgggctgca ggagctgggg ccacccacag cccccctacc gacctggtgt ggaaggcaca gaacacctgg ggctgcggga acagcctgcg tacggctctc atcaactcca ctggggaaga agtggccatg cgcaagctgg tgcgctcagt gactgtggtt gaggacgacg aggatgagga tggagatgac ctgctccatc accaccacgg ctcccactgc agcagctcgg gggaccccgc tgagtacaac ctgcgctcgc gcaccgtgct gtgcgggacc tgcgggcagc ctgccgacaa ggcatctgcc agcggctcag gagcccaggt gggcggaccc atctcctctg gctcttctgc ctccagtgtc acggtcactc gcagctaccg cagtgtgggg ggcagtgggg gtggcagctt cggggacaat ctggtcaccc gctcctacct cctgggcaac tccagccccc gaacccagag cccccagaac tgcagcatca tgtaa

Molecular Weight

69,249 Da

OMIM

115200

Vector

Please Inquire

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of LMNA cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for LMNA. It may not necessarily be applicable to this product.

NCBI GI #

15680286

NCBI GeneID

4000

NCBI Accession #

BC014507

UniProt Secondary Accession #

P02546; Q5I6Y4; Q5I6Y6; Q5TCJ2; Q5TCJ3; Q6UYC3; Q969I8; B4DI32; D3DVB0; D6RAQ3; E7EUI9

UniProt Related Accession #

P02545

NCBI Official Full Name

Homo sapiens lamin A/C, mRNA

NCBI Official Synonym Full Names

lamin A/C

NCBI Official Symbol

LMNA

NCBI Official Synonym Symbols

FPL; IDC; LFP; CDDC; EMD2; FPLD; HGPS; LDP1; LMN1; LMNC; PRO1; CDCD1; CMD1A; FPLD2; LMNL1; CMT2B1; LGMD1B

UniProt Protein Name

Prelamin-A/C

UniProt Synonym Protein Names

Lamin-A/CAlternative name(s):70 kDa lamin; Renal carcinoma antigen NY-REN-32

Protein Family

Lamin

UniProt Gene Name

LMNA

UniProt Synonym Gene Names

LMN1

UniProt Entry Name

LMNA_HUMAN

NCBI Protein Information

lamin

NCBI Summary for LMNA

The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012]

UniProt Comments for LMNA

lamin A/C: nuclear lamins are intermediate filament proteins that constitute the lattice-like matrix at the inner face of the nuclear membrane that underlies the nuclear envelop. The lamins, highly conserved throughout evolution, are encoded by three genes in the human: LMNA, LMNB1, and LMNB2. The A-type lamins (lamin A/C) are developmentally regulated and are generally expressed in differentiated cells. The anchoring of chromatin to the nuclear lamina is involved in the control of gene expression and in DNA replication and repair. During mitosis, the nuclear lamina is reversibly disassembled as the lamin proteins are phosphorylated. Cleaved by caspase-6 during apoptosis into a 40-45 kDa and a28 kDa fragment.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 1q22

Cellular Component: cytoplasm; cytosol; extracellular matrix; nuclear envelope; nuclear membrane; nucleoplasm; nucleus

Molecular Function: protein binding

Biological Process: establishment and/or maintenance of microtubule cytoskeleton polarity; mitotic nuclear envelope disassembly; mitotic nuclear envelope reassembly; regulation of cell migration

Disease: Cardiomyopathy, Dilated, 1a; Cardiomyopathy, Dilated, With Hypergonadotropic Hypogonadism; Charcot-marie-tooth Disease, Axonal, Type 2b1; Emery-dreifuss Muscular Dystrophy 2, Autosomal Dominant; Emery-dreifuss Muscular Dystrophy 3, Autosomal Recessive; Heart-hand Syndrome, Slovenian Type; Hutchinson-gilford Progeria Syndrome; Lipodystrophy, Familial Partial, Type 2; Mandibuloacral Dysplasia With Type A Lipodystrophy; Muscular Dystrophy, Congenital, Lmna-related; Muscular Dystrophy, Limb-girdle, Type 1b; Restrictive Dermopathy, Lethal

Research Articles on LMNA

1. Data show that all-trans retinoic acid acts synergistically with rapamycin reducing progerin and prelamin A.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with LMNA cdna clone

Products by Pathway	Pathway Diagram
Activation Of Chaperone Genes By XBP1(S) Pathway antibodies	Activation Of Chaperone Genes By XBP1(S) Pathway Diagram
Activation Of Chaperones By IRE1alpha Pathway antibodies	Activation Of Chaperones By IRE1alpha Pathway Diagram
Adipogenesis Pathway antibodies	Adipogenesis Pathway Diagram
Apoptosis Pathway antibodies	Apoptosis Pathway Diagram
Apoptotic Cleavage Of Cellular Proteins Pathway antibodies	Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
Apoptotic Execution Phase Pathway antibodies	Apoptotic Execution Phase Pathway Diagram
Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies	Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies	Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies	Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
Breakdown Of The Nuclear Lamina Pathway antibodies	Breakdown Of The Nuclear Lamina Pathway Diagram

Diseases associated with LMNA cdna clone

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>230 publications with LMNA and Cardiovascular Diseases
Progeria Antibodies	>212 publications with LMNA and Progeria
Hutchinson Gilford progeria syndrome Antibodies	>212 publications with LMNA and Hutchinson Gilford progeria syndrome
Heart Diseases Antibodies	>204 publications with LMNA and Heart Diseases
Cardiomyopathy, Dilated Antibodies	>180 publications with LMNA and Cardiomyopathy, Dilated
Muscular Dystrophy, Emery-Dreifuss Antibodies	>132 publications with LMNA and Muscular Dystrophy, Emery-Dreifuss
Lipodystrophy, Familial Partial Antibodies	>120 publications with LMNA and Lipodystrophy, Familial Partial
LIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 2 Antibodies	>120 publications with LMNA and LIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 2
Death, Sudden, Cardiac Antibodies	>45 publications with LMNA and Death, Sudden, Cardiac
Muscular Dystrophies, Limb-Girdle Antibodies	>35 publications with LMNA and Muscular Dystrophies, Limb-Girdle

Organs/Tissues associated with LMNA cdna clone

Organ/Tissue Name	Pubmed Publications
Muscle Antibodies	>228 publications with LMNA and Muscle
Heart Antibodies	>159 publications with LMNA and Heart
Skin Antibodies	>104 publications with LMNA and Skin
Adipose Tissue Antibodies	>80 publications with LMNA and Adipose Tissue
Blood Antibodies	>69 publications with LMNA and Blood
Bone Antibodies	>63 publications with LMNA and Bone
Nerve Antibodies	>46 publications with LMNA and Nerve
Connective Tissue Antibodies	>42 publications with LMNA and Connective Tissue
Vascular Antibodies	>36 publications with LMNA and Vascular
Brain Antibodies	>19 publications with LMNA and Brain