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LUM cDNA Clone – Lumican (Human)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1276777

MBS1276777 is a cDNA clone targeting LUM. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
LUM, cDNA Clone
Full Product Name
LUM cDNA Clone
Product Gene Name
LUM cdna clone
Sequence
atgagtctaa gtgcatttac tctcttcctg gcattgattg gtggtaccag tggccagtac tatgattatg attttcccct atcaatttat gggcaatcat caccaaactg tgcaccagaa tgtaactgcc ctgaaagcta cccaagtgcc atgtactgtg atgagctgaa attgaaaagt gtaccaatgg tgcctcctgg aatcaagtat ctttacctta ggaataacca gattgaccat attgatgaaa aggcctttga gaatgtaact gatctgcagt ggctcattct agatcacaac cttctagaaa actccaagat aaaagggaga gttttctcta aattgaaaca actgaagaag ctgcatataa accacaacaa cctgacagag tctgtgggcc cacttcccaa atctctggag gatctgcagc ttactcataa caagatcaca aagctgggct cttttgaagg attggtaaac ctgaccttca tccatctcca gcacaaccgg ctgaaagagg atgctgtttc agctgctttt aaaggtctta aatcactcga ataccttgac ttgagcttca atcagatagc cagactgcct tctggtctcc ctgtctctct tctaactctc tacttagaca acaataagat cagcaacatc cctgatgagt atttcaagcg ttttaatgca ttgcagtatc tgcgtttatc tcacaacgaa ctggctgata gtggaatacc tggaaattct ttcaatgtgt catccctggt tgagctggat ctgtcctata acaagcttaa aaacatacca actgtcaatg aaaaccttga aaactattac ctggaggtca atcaacttga gaagtttgac ataaagagct tctgcaagat cctggggcca ttatcctact ccaagatcaa gcatttgcgt ttggatggca atcgcatctc agaaaccagt cttccaccgg atatgtatga atgtctacgt gttgctaacg aagtcactct taattaa
Molecular Weight
38,429 Da
OMIM
600616
Vector
pENTR223.1 or pUC
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of LUM cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for LUM. It may not necessarily be applicable to this product.

NCBI GI #
23271182
NCBI GeneID
4060
NCBI Accession #
BC035997
UniProt Secondary Accession #
Q96QM7; B2R6R5
UniProt Related Accession #
P51884
NCBI Official Full Name
Homo sapiens lumican, mRNA
NCBI Official Synonym Full Names
lumican
NCBI Official Symbol
LUM
NCBI Official Synonym Symbols
LDC; SLRR2D
UniProt Protein Name
Lumican
UniProt Synonym Protein Names
Keratan sulfate proteoglycan lumican; KSPG lumican
Protein Family
Lumican
UniProt Gene Name
LUM
UniProt Synonym Gene Names
LDC; SLRR2D; KSPG lumican
UniProt Entry Name
LUM_HUMAN
NCBI Protein Information
lumican

NCBI Summary for LUM

This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair. [provided by RefSeq, Jul 2008]
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UniProt Comments for LUM

LUM: a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair. [provided by RefSeq, Jul 2008]

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 12q21.33

Cellular Component: extracellular matrix; extracellular region; extracellular space; fibrillar collagen; Golgi lumen; lysosomal lumen; proteinaceous extracellular matrix

Molecular Function: collagen binding; protein binding

Biological Process: axonogenesis; extracellular matrix organization and biogenesis; keratan sulfate biosynthetic process; keratan sulfate catabolic process
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Research Articles on LUM

1. fibroblasts stimulated with the fibrocyte-secreted inflammatory signal tumor necrosis factor-alpha secrete the small leucine-rich proteoglycan lumican.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with LUM cdna clone

 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Glycosaminoglycan Metabolism Pathway antibodies  Glycosaminoglycan Metabolism Pathway Diagram
 Keratan Sulfate Biosynthesis Pathway antibodies  Keratan Sulfate Biosynthesis Pathway Diagram
 Keratan Sulfate Degradation Pathway antibodies  Keratan Sulfate Degradation Pathway Diagram
 Keratan Sulfate/keratin Metabolism Pathway antibodies  Keratan Sulfate/keratin Metabolism Pathway Diagram
 MPS I - Hurler Syndrome Pathway antibodies  MPS I - Hurler Syndrome Pathway Diagram
 MPS II - Hunter Syndrome Pathway antibodies  MPS II - Hunter Syndrome Pathway Diagram
 MPS IIIA - Sanfilippo Syndrome A Pathway antibodies  MPS IIIA - Sanfilippo Syndrome A Pathway Diagram
 MPS IIIB - Sanfilippo Syndrome B Pathway antibodies  MPS IIIB - Sanfilippo Syndrome B Pathway Diagram
 MPS IIIC - Sanfilippo Syndrome C Pathway antibodies  MPS IIIC - Sanfilippo Syndrome C Pathway Diagram

Diseases associated with LUM cdna clone

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >326 publications with LUM and Neoplasms
 Brain Diseases Antibodies  >126 publications with LUM and Brain Diseases
 Carcinoma Antibodies  >87 publications with LUM and Carcinoma
 Disease Models, Animal Antibodies  >64 publications with LUM and Disease Models, Animal
 Drug Toxicity Antibodies  >64 publications with LUM and Drug Toxicity
 Inflammation Antibodies  >63 publications with LUM and Inflammation
 Kidney Diseases Antibodies  >57 publications with LUM and Kidney Diseases
 Necrosis Antibodies  >53 publications with LUM and Necrosis
 Breast Neoplasms Antibodies  >52 publications with LUM and Breast Neoplasms
 Liver Diseases Antibodies  >49 publications with LUM and Liver Diseases

Organs/Tissues associated with LUM cdna clone

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >486 publications with LUM and Blood
 Bone Antibodies  >149 publications with LUM and Bone
 Vascular Antibodies  >146 publications with LUM and Vascular
 Lung Antibodies  >135 publications with LUM and Lung
 Brain Antibodies  >103 publications with LUM and Brain
 Bone Marrow Antibodies  >98 publications with LUM and Bone Marrow
 Liver Antibodies  >87 publications with LUM and Liver
 Kidney Antibodies  >84 publications with LUM and Kidney
 Muscle Antibodies  >75 publications with LUM and Muscle
 Heart Antibodies  >73 publications with LUM and Heart
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