Human MAGI3 cDNA Clone Expression Plasmid – Cat# MBS1277387

MAGI3 cDNA Clone – Membrane Associated Guanylate Kinase, Ww and PDZ Domain Containing 3 (Human)

Name: MAGI3 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1277387
Price: 1450 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1277387

MBS1277387 is a cDNA clone targeting MAGI3. More details

$1450 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MAGI3, cDNA Clone

Full Product Name

MAGI3 cDNA Clone

Product Gene Name

MAGI3 cdna clone

Sequence

atgtcgaaga cgctgaagaa gaagaagcac tggctcagca aggtgcagga gtgcgccgtg tcctgggccg ggcccccggg cgacttcggc gcggagatcc gcggtggcgc ggagcgtggc gagttcccct acctggggcg gctccgcgag gagcccggcg ggggcacctg ctgcgtcgtc tcgggcaagg cgcccagccc aggcgatgtg ctgctggagg taaacgggac gcctgtcagc gggctcacca accgggacac cctggctgtc atccgccact tccgcgagcc catccgtctc aagactgtga aaccaggcaa agtcattaat aaagatttgc ggcattacct aagtcttcag tttcaaaaag gatcaattga ccacaaactg cagcaagtga tcagagataa tctctacttg agaaccattc catgcactac aagggccccc agggatggag aagtaccagg agtggattat aatttcattt ccgttgaaca gttcaaagca ctggaagaga gtggagcatt gttagaaagt gggacatatg atggaaactt ctatggaact cccaagcctc cagcagaacc cagccctttt cagccagatc cagttgatca agtcctcttt gataatgagt ttgatgcaga atctcaaaga aaacgaacga catctgtcag caagatggaa agaatggata gctctcttcc tgaagaggaa gaagatgagg acaaggaagc tattaatggc agtggaaacg cagaaaacag agagaggcat tctgagtcat ctgactggat gaagactgtt ccaagttaca accaaacaaa tagctccatg gactttagaa attatatgat gagagatgag actctggaac cactgcccaa aaactgggaa atggcctaca ctgacacagg gatgatctac ttcattgacc acaataccaa gacaaccacc tggttggatc ctcgtctttg taagaaagcc aaagcccctg aagactgtga agatggagag cttccttatg gctgggagaa aatagaggac cctcagtatg ggacatacta tgttgatcac cttaaccaga aaacccagtt tgaaaatcca gtggaggaag ccaaaaggaa aaagcagtta ggacaggttg aaattgggtc ttcaaaacca gatatggaaa aatcacactt cacaagagat ccatcccagc ttaaaggtgt ccttgttcga gcatcactga aaaaaagcac aatgggattt ggttttacta ttattggtgg agatagacct gatgagttcc tacaagtgaa aaatgtgctg aaagatggtc ccgcagctca ggatgggaaa attgcaccag gcgatgttat tgtagacatc aatggcaact gtgtcctcgg tcacactcat gcagatgttg tccagatgtt tcaattggta cctgtcaatc agtatgtaaa cctcacttta tgtcgtggtt atccacttcc tgatgacagt gaagatcctg ttgtggacat tgttgctgct acccctgtca tcaatggaca gtcattaacc aagggagaga cttgcatgaa tcctcaggat tttaagccag gagcaatggt tctggagcag aatggaaaat cgggacacac tttgactggt gatggtctca atggaccatc agatgcaagt gagcagagag tatccatggc atcgtcaggc agctcccagc ctgaactagt gactatccct ttgattaagg gccctaaagg gtttgggttt gcaattgctg acagccctac tggacagaag gtgaaaatga tactggatag tcagtggtgt caaggccttc agaaaggaga tataattaag gaaatatacc atcaaaatgt gcagaattta acacatctcc aagtggtaga ggtgctaaag cagtttccag taggtgctga tgtaccattg cttatcttaa gaggaggtcc tccttcacca accaaaactg ccaaaatgaa aacagataaa aaggaaaatg caggaagttt ggaggccata aatgagccta ttcctcagcc tatgcctttt ccaccgagca ttatcaggtc aggatcccca aaattggatc cttctgaggt ctacctgaaa tctaagactt tatatgaaga taaaccacca aacaccaaag atttggatgt ttttcttcga aaacaagagt cagggtttgg cttcagggtg ctaggaggag atggacctga ccagtctata tatattgggg ctattattcc cctgggagca gctgagaaag atggtcggct ccgcgcagct gatgaactaa tgtgcattga tggaattcct gttaaaggga aatcacacaa acaagtcttg gacctcatga caactgctgc tcgaaatggc catgtgttac taactgtcag acggaagatc ttctatggag aaaaacaacc cgaggacgac agctctcagg ccttcatttc aacacagaat ggatctcccc gcctgaaccg ggcagaggtc ccagccaggc ctgcacccca ggagccctat gatgttgtct tgcaacgaaa agaaaatgaa ggatttggct ttgtcatcct cacctccaaa aacaaaccac ctccaggagt tattcctcat aaaattggcc gagtcataga aggaagtccg gctgaccgct gtggaaaact gaaagttgga gatcatatct ctgcagtgaa tgggcagtcc attgttgaac tgtctcatga taacattgtt cagctgatca aagatgctgg tgtcaccgtc acactaacgg tcattgctga agaagagcat catggtccac catcaggaac aaactcagcc aggcaaagcc cagccctgca gcacaggccc atgggacagt cacaggccaa ccacatacct ggggacagaa gtgccctaga aggtgaaatt ggaaaagatg tctccacttc ttacagacat tcttggtcag accacaagca ccttgcacag cctgacaccg cagtaatttc agttgtaggc agtcggcaca atcagaacct tggttgttat ccagtagagc tggagagagg cccccggggc tttggattca gcctccgagg ggggaaggag tacaacatgg ggctgttcat ccttcgtctt gctgaagatg gtcctgccat caaagatggc agaattcatg ttggtgacca gattgttgaa atcaatgggg aacctacaca aggaatcaca catactcgag caattgagct cattcaggct ggtggaaata aagttcttct tcttttgagg ccaggaactg gcttgatacc tgaccatggt ttggctcctt ccggtctgtg ctcctacgtg aaacccgagc aacattaa

Molecular Weight

162,949 Da

OMIM

615943

Vector

pUC

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of MAGI3 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MAGI3. It may not necessarily be applicable to this product.

NCBI GI #

120659857

NCBI GeneID

260425

NCBI Accession #

BC130409

UniProt Secondary Accession #

Q5TCQ8; Q5TCR0; Q9H2V6; Q9H5Y8; Q9HBC4; Q9HCD8

UniProt Related Accession #

Q5TCQ9

NCBI Official Full Name

Homo sapiens membrane associated guanylate kinase, WW and PDZ domain containing 3, mRNA

NCBI Official Synonym Full Names

membrane associated guanylate kinase, WW and PDZ domain containing 3

NCBI Official Symbol

MAGI3

NCBI Official Synonym Symbols

MAGI-3; dJ730K3.2

UniProt Protein Name

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3

UniProt Synonym Protein Names

Membrane-associated guanylate kinase inverted 3; MAGI-3

Protein Family

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein

UniProt Gene Name

MAGI3

UniProt Synonym Gene Names

KIAA1634; MAGI-3

UniProt Entry Name

MAGI3_HUMAN

NCBI Protein Information

membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3

UniProt Comments for MAGI3

MAGI3: a protein of the MAGUK family of proteins. A peripheral membrane protein found at cell-cell junctions. Contains one guanylate kinase, two WW, and four PDZ domains. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2. Interacts with ADRB1, FZD4, FZD7, PTPRB, TGFA and VANGL2. Interacts with BAI1, LPAR2/EDG4, GRIN2B and PTEN. In case of infection, interacts with HTLV TAX1 protein, possibly affecting the transformation ability of TAX1. Does not interact with HTLV TAX2 or TAX3 proteins. Interacts with HPV type 16 and HPV type 18 E6 protein. Ubiquitinated following interaction with HPV E6 protein, leading to its degradation by the proteasome. Degradation is independent of E6AP ubiquitin ligase complex. Four alternatively spliced human isoforms have been described.

Protein type: Kinase, other; Membrane protein, peripheral

Chromosomal Location of Human Ortholog: 1p13.2

Molecular Function: protein binding

Research Articles on MAGI3

1. Expression levels of MAGI3 and PTEN were significantly downregulated in gliomas.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with MAGI3 cdna clone

Products by Pathway	Pathway Diagram
Tight Junction Pathway antibodies	Tight Junction Pathway Diagram
Tight Junction Pathway antibodies	Tight Junction Pathway Diagram
Wnt Signaling Pathway NetPath antibodies	Wnt Signaling Pathway NetPath Diagram

Diseases associated with MAGI3 cdna clone

Disease Name	Pubmed Publications
Neoplasms Antibodies	>4 publications with MAGI3 and Neoplasms
Carcinoma Antibodies	>3 publications with MAGI3 and Carcinoma
Colonic Neoplasms Antibodies	>1 publications with MAGI3 and Colonic Neoplasms
Lung Neoplasms Antibodies	>1 publications with MAGI3 and Lung Neoplasms
Carcinoma, Hepatocellular Antibodies	>1 publications with MAGI3 and Carcinoma, Hepatocellular

Organs/Tissues associated with MAGI3 cdna clone

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>1 publications with MAGI3 and Lung
Eye Antibodies	>1 publications with MAGI3 and Eye
Brain Antibodies	>1 publications with MAGI3 and Brain