Human MAN1B1 cDNA Clone Expression Plasmid – Cat# MBS1272348

MAN1B1 cDNA Clone – Mannosidase, Alpha, Class 1b, Member 1 (Human)

Name: MAN1B1 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1272348
Price: 520 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1272348

MBS1272348 is a cDNA clone targeting MAN1B1. More details

$520 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MAN1B1, cDNA Clone

Full Product Name

MAN1B1 cDNA Clone

Product Gene Name

MAN1B1 cdna clone

Sequence

atggctgcct gcgagggcag gagaagcgga gctctcggtt cctctcagtc ggacttcctg acgccgccag tgggcggggc cccttgggcc gtcgccacca ctgtagtcat gtacccaccg ccgccgccgc cgcctcatcg ggacttcatc tcggtgacgc tgagctttgg cgagaactat gacaacagca agagttggcg gcggcgctcg tgctggagga aatggaagca actgtcgaga ttgcagcgga atatgattct cttcctcctt gcctttctgc ttttctgtgg actcctcttc tacatcaact tggctgacca ttggaaagct ctggctttca ggctagagga agagcagaag atgaggccag aaattgctgg gttaaaacca gcaaatccac ccgtcttacc agctcctcag aaggcggaca ccgaccctga gaacttacct gagatttcgt cacagaagac acaaagacac atccagcggg gaccacctca cctgcagatt agacccccaa gccaagacct gaaggatggg acccaggagg aggccacaaa aaggcaagaa gcccctgtgg atccccgccc ggaaggagat ccgcagagga cagtcatcag ctggagggga gcggtgatcg agcctgagca gggcaccgag ctcccttcaa gaagagcaga agtgcccacc aagcctcccc tgccaccggc caggacacag ggcacaccag tgcatctgaa ctatcgccag aagggcgtga ttgacgtctt cctgcatgca tggaaaggat accgcaagtt tgcatggggc catgacgagc tgaagcctgt gtccaggtcc ttcagtgagt ggtttggcct cggtctcaca ctgatcgacg cgctggacac catgtggatc ttgggtctga ggaaagaatt tgaggaagcc aggaagtggg tgtcgaagaa gttacacttt gaaaaggacg tggacgtcaa cctgtttgag agcacgatcc gcatcctggg ggggctcctg agtgcctacc acctgtctgg ggacagcctc ttcctgagga aagctgagga ttttggaaat cggctaatgc ctgccttcag aacaccatcc aagattcctt actcggatgt gaacatcggt actggagttg cccacccgcc acggtggacc tccgacagca ctgtggccga ggtgaccagc attcagctgg agttccggga gctctcccgt ctcacagggg ataagaagtt tcaggaggca gtggagaagg tgacacagca catccacggc ctgtctggga agaaggatgg gctggtgccc atgttcatca atacccacag tggcctcttc acccacctgg gcgtattcac gctgggcgcc agggccgaca gctactatga gtacctgctg aagcagtgga tccagggcgg gaagcaggag acacagctgc tggaagacta cgtggaagcc atcgagggtg tcagaacgca cctgctgcgg cactccgagc ccagtaagct cacctttgtg ggggagcttg cccacggccg cttcagtgcc aagatggacc acctggtgtg cttcctgcca gggacgctgg ctctgggcgt ctaccacggc ctgcccgcca gccacatgga gctggcccag gagctcatgg agacttgtta ccagatgaac cggcagatgg agacggggct gagtcccgag atcgtgcact tcaaccttta cccccagccg ggccgtcggg acgtggaggt caagccagca gacaggcaca acctgctgcg gccagagacc gtggagagcc tgttctacct gtaccgcgtc acaggggacc gcaaatacca ggactggggc tgggagattc tgcagagctt cagccgattc acacgggtcc cctcgggtgg ctattcttcc atcaacaatg tccaggatcc tcagaagccc gagcctaggg acaagatgga gagcttcttc ctgggggaga cgctcaagta tctgttcttg ctcttctccg atgacccaaa cctgctcagc ctggacgcct acgtgttcaa caccgaagcc caccctctgc ctatctggac ccctgcctag

Molecular Weight

79,580 Da

OMIM

604346

Vector

pENTR223.1 or pUC

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of MAN1B1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MAN1B1. It may not necessarily be applicable to this product.

NCBI GI #

13543862

NCBI GeneID

11253

NCBI Accession #

BC006079

UniProt Secondary Accession #

Q5VSG3; Q9BRS9; Q9Y5K7

UniProt Related Accession #

Q9UKM7

NCBI Official Full Name

Homo sapiens mannosidase, alpha, class 1B, member 1, mRNA

NCBI Official Synonym Full Names

mannosidase alpha class 1B member 1

NCBI Official Symbol

MAN1B1

NCBI Official Synonym Symbols

MRT15; ERMAN1; ERManI; MANA-ER

UniProt Protein Name

Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase

UniProt Synonym Protein Names

ER alpha-1,2-mannosidase; ER mannosidase 1; ERMan1; Man9GlcNAc2-specific-processing alpha-mannosidase; Mannosidase alpha class 1B member 1

Protein Family

Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase

UniProt Gene Name

MAN1B1

UniProt Synonym Gene Names

ERMan1

UniProt Entry Name

MA1B1_HUMAN

NCBI Protein Information

endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase

NCBI Summary for MAN1B1

This gene encodes an enzyme belonging to the glycosyl hydrolase 47 family. This enzyme functions in N-glycan biosynthesis, and is a class I alpha-1,2-mannosidase that specifically converts Man9GlcNAc to Man8GlcNAc isomer B. It is required for N-glycan trimming to Man5-6GlcNAc2 in the endoplasmic-reticulum-associated degradation pathway. Mutations in this gene cause autosomal-recessive intellectual disability. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 11. [provided by RefSeq, Dec 2011]

UniProt Comments for MAN1B1

MAN1B1: Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2). Defects in MAN1B1 are the cause of mental retardation autosomal recessive type 15 (MRT15). Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Belongs to the glycosyl hydrolase 47 family.

Protein type: Calcium-binding; EC 3.2.1.113; Endoplasmic reticulum; Glycan Metabolism - N-glycan biosynthesis; Hydrolase; Membrane protein, integral

Chromosomal Location of Human Ortholog: 9q34

Cellular Component: endoplasmic reticulum; Golgi apparatus; integral to membrane; membrane

Molecular Function: alpha-mannosidase activity; calcium ion binding; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity

Biological Process: ER-associated protein catabolic process; N-glycan processing; oligosaccharide metabolic process

Disease: Mental Retardation, Autosomal Recessive 15

Research Articles on MAN1B1

1. Data show that HIV-1 env protein interacts with alpha-mannosidases ERManI (MAN1B1) and initiates endoplasmic reticulum (ER)-associated protein degradation (ERAD) pathway degradation process.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with MAN1B1 cdna clone

Products by Pathway	Pathway Diagram
Asparagine N-linked Glycosylation Pathway antibodies	Asparagine N-linked Glycosylation Pathway Diagram
Calnexin/calreticulin Cycle Pathway antibodies	Calnexin/calreticulin Cycle Pathway Diagram
ER Quality Control Compartment (ERQC) Pathway antibodies	ER Quality Control Compartment (ERQC) Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
N-Glycan Biosynthesis Pathway antibodies	N-Glycan Biosynthesis Pathway Diagram
N-Glycan Biosynthesis Pathway antibodies	N-Glycan Biosynthesis Pathway Diagram
N-glycan Precursor Trimming Pathway antibodies	N-glycan Precursor Trimming Pathway Diagram
N-glycan Precursor Trimming Pathway antibodies	N-glycan Precursor Trimming Pathway Diagram
N-glycan Trimming In The ER And Calnexin/Calreticulin Cycle Pathway antibodies	N-glycan Trimming In The ER And Calnexin/Calreticulin Cycle Pathway Diagram
Post-translational Protein Modification Pathway antibodies	Post-translational Protein Modification Pathway Diagram

Diseases associated with MAN1B1 cdna clone

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>2 publications with MAN1B1 and Nervous System Diseases
Liver Diseases Antibodies	>1 publications with MAN1B1 and Liver Diseases

Organs/Tissues associated with MAN1B1 cdna clone

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>1 publications with MAN1B1 and Liver
Brain Antibodies	>1 publications with MAN1B1 and Brain