Human MASP1 cDNA Clone Expression Plasmid – Cat# MBS1266846

MASP1 cDNA Clone – Mannan-Binding Lectin Serine Peptidase 1 (C4/C2 Activating Component of Ra-Reactive Factor) (Human)

Name: MASP1 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1266846
Price: 520 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1266846

MBS1266846 is a cDNA clone targeting MASP1. More details

$520 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MASP1, cDNA Clone

Full Product Name

MASP1 cDNA Clone

Product Gene Name

MASP1 cdna clone

Sequence

ATGAGGTGGC TGCTTCTCTA TTATGCTCTG TGCTTCTCCC TGTCAAAGGC TTCAGCCCAC ACCGTGGAGC TAAACAATAT GTTTGGCCAG ATCCAGTCGC CTGGTTATCC AGACTCCTAT CCCAGTGATT CAGAGGTGAC TTGGAATATC ACTGTCCCAG ATGGGTTTCG GATCAAGCTT TACTTCATGC ACTTCAACTT GGAATCCTCC TACCTTTGTG AATATGACTA TGTGAAGGTA GAAACTGAGG ACCAGGTGCT GGCAACCTTC TGTGGCAGGG AGACCACAGA CACAGAGCAG ACTCCCGGCC AGGAGGTGGT CCTCTCCCCT GGCTCCTTCA TGTCCATCAC TTTCCGGTCA GATTTCTCCA ATGAGGAGCG TTTCACAGGC TTTGATGCCC ACTACATGGC TGTGGATGTG GACGAGTGCA AGGAGAGGGA GGACGAGGAG CTGTCCTGTG ACCACTACTG CCACAACTAC ATTGGCGGCT ACTACTGCTC CTGCCGCTTC GGCTACATCC TCCACACAGA CAACAGGACC TGCCGAGTGG AGTGCAGTGA CAACCTCTTC ACTCAAAGGA CTGGGGTGAT CACCAGCCCT GACTTCCCAA ACCCTTACCC CAAGAGCTCT GAATGCCTGT ATACCATCGA GCTGGAGGAG GGTTTCATGG TCAACCTGCA GTTTGAGGAC ATATTTGACA TTGAGGACCA TCCTGAGGTG CCCTGCCCCT ATGACTACAT CAAGATCAAA GTTGGTCCAA AAGTTTTGGG GCCTTTCTGT GGAGAGAAAG CCCCAGAACC CATCAGCACC CAGAGCCACA GTGTCCTGAT CCTGTTCCAT AGTGACAACT CGGGAGAGAA CCGGGGCTGG AGGCTCTCAT ACAGGGCTGC AGGAAATGAG TGCCCAGAGC TACAGCCTCC TGTCCATGGG AAAATCGAGC CCTCCCAAGC CAAGTATTTC TTCAAAGACC AAGTGCTCGT CAGCTGTGAC ACAGGCTACA AAGTGCTGAA GGATAATGTG GAGATGGACA CATTCCAGAT TGAGTGTCTG AAGGATGGGA CGTGGAGTAA CAAGATTCCC ACCTGTAAAA TTGTAGACTG TAGAGCCCCA GGAGAGCTGG AACACGGGCT GATCACCTTC TCTACAAGGA ACAACCTCAC CACATACAAG TCTGAGATCA AATACTCCTG TCAGGAGCCC TATTACAAGA TGCTCAACAA TAACACAGGT ATATATACCT GTTCTGCCCA AGGAGTCTGG ATGAATAAAG TATTGGGGAG AAGCCTACCC ACCTGCCTTC CAGAGTGTGG TCAGCCCTCC CGCTCCCTGC CAAGCCTGGT CAAGAGGATC ATTGGGGGCC GAAATGCTGA GCCCGGCCTC TTCCCGTGGC AGGCCCTGAT AGTGGTGGAG GACACTTCGA GAGTGCCAAA TGACAAGTGG TTTGGGAGTG GGGCCCTGCT CTCTGCGTCC TGGATCCTCA CAGCAGCTCA TGTGCTGCGC TCCCAGCGTA GAGACACCAC GGTGATACCA GTCTCCAAGG AGCATGTCAC CGTCTACCTG GGCTTGCATG ATGTGCGAGA CAAATCGGGG GCAGTCAACA GCTCAGCTGC CCGAGTGGTG CTCCACCCAG ACTTCAACAT CCAAAACTAC AACCACGATA TAGCTCTGGT GCAGCTGCAG GAGCCTGTGC CCCTGGGACC CCACGTTATG CCTGTCTGCC TGCCAAGGCT TGAGCCTGAA GGCCCGGCCC CCCACATGCT GGGCCTGGTG GCCGGCTGGG GCATCTCCAA TCCCAATGTG ACAGTGGATG AGATCATCAG CAGTGGCACA CGGACCTTGT CAGATGTCCT ACAGTATGTC AAGTTACCCG TGGTGCCTCA CGCTGAGTGC AAAACTAGCT ATGAGTCCCG CTCGGGCAAT TACAGCGTCA CGGAGAACAT GTTCTGTGCT GGCTACTACG AGGGCGGCAA AGACACGTGC CTTGGAGATA GCGGTGGGGC CTTTGTCATC TTTGATGACT TGAGCCAGCG CTGGGTGGTG CAAGGCCTGG TGTCCTGGGG GGGACCTGAA GAATGCGGCA GCAAGCAGGT CTATGGAGTC TACACAAAGG TCTCCAATTA CGTGGACTGG GTGTGGGAGC AGATGGGCTT ACCACAAAGT GTTGTGGAGC CCCAGGTGGA ACGGTGA

Molecular Weight

68,918 Da

OMIM

257920

Vector

pENTR223.1 or pUC

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of MASP1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MASP1. It may not necessarily be applicable to this product.

NCBI GI #

76827915

NCBI GeneID

5648

NCBI Accession #

BC106945

UniProt Secondary Accession #

O95570; Q68D21; Q8IUV8; Q96RS4; Q9UF09; A8K542; A8K6M1; B4E2L7

UniProt Related Accession #

P48740

NCBI Official Full Name

Homo sapiens mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor), mRNA

NCBI Official Synonym Full Names

mannan binding lectin serine peptidase 1

NCBI Official Symbol

MASP1

NCBI Official Synonym Symbols

3MC1; MAP1; MASP; RaRF; CRARF; MASP3; MAp44; PRSS5; CRARF1

UniProt Protein Name

Mannan-binding lectin serine protease 1

UniProt Synonym Protein Names

Complement factor MASP-3; Complement-activating component of Ra-reactive factor; Mannose-binding lectin-associated serine protease 1; MASP-1

Protein Family

Mannan-binding lectin serine protease

UniProt Gene Name

MASP1

UniProt Synonym Gene Names

CRARF; CRARF1; PRSS5; MASP-1; RaRF

UniProt Entry Name

MASP1_HUMAN

NCBI Protein Information

mannan-binding lectin serine protease 1

NCBI Summary for MASP1

This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]

UniProt Comments for MASP1

MASP1: Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5. Defects in MASP1 are the cause of 3MC syndrome type 1 (3MC1). 3MC1 is a disorder characterized by facial dysmorphism that includes hypertelorism, blepharophimosis, blepharoptosis and highly arched eyebrows, cleft lip and/or palate, craniosynostosis, learning disability and genital, limb and vesicorenal anomalies. The term 3MC syndrome includes Carnevale, Mingarelli, Malpuech, and Michels syndromes. Belongs to the peptidase S1 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Protease; Secreted; EC 3.4.21.-

Chromosomal Location of Human Ortholog: 3q27-q28

Cellular Component: extracellular region; extracellular space

Molecular Function: calcium ion binding; calcium-dependent protein binding; peptidase activity; protein binding; protein homodimerization activity; serine-type endopeptidase activity

Biological Process: complement activation; complement activation, lectin pathway; receptor-mediated endocytosis

Disease: 3mc Syndrome 1

Research Articles on MASP1

1. described for the first time a detailed model of prothrombin activation by MASP-1

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with MASP1 cdna clone

Products by Pathway	Pathway Diagram
Complement Activation, Classical Pathway antibodies	Complement Activation, Classical Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement Cascade Pathway antibodies	Complement Cascade Pathway Diagram
Creation Of C4 And C2 Activators Pathway antibodies	Creation Of C4 And C2 Activators Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Initial Triggering Of Complement Pathway antibodies	Initial Triggering Of Complement Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram
Lectin Pathway Of Complement Activation antibodies	Lectin Pathway Of Complement Activation Diagram

Diseases associated with MASP1 cdna clone

Disease Name	Pubmed Publications
Inflammation Antibodies	>10 publications with MASP1 and Inflammation
Immune System Diseases Antibodies	>6 publications with MASP1 and Immune System Diseases
Neoplasms Antibodies	>4 publications with MASP1 and Neoplasms
Cardiovascular Diseases Antibodies	>4 publications with MASP1 and Cardiovascular Diseases
Nervous System Diseases Antibodies	>4 publications with MASP1 and Nervous System Diseases
Heart Diseases Antibodies	>3 publications with MASP1 and Heart Diseases
Liver Diseases Antibodies	>3 publications with MASP1 and Liver Diseases
Craniofacial Abnormalities Antibodies	>3 publications with MASP1 and Craniofacial Abnormalities
Oculopalatoskeletal syndrome Antibodies	>2 publications with MASP1 and Oculopalatoskeletal syndrome
Malpuech facial clefting syndrome Antibodies	>2 publications with MASP1 and Malpuech facial clefting syndrome

Organs/Tissues associated with MASP1 cdna clone

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>12 publications with MASP1 and Liver
Heart Antibodies	>6 publications with MASP1 and Heart
Lung Antibodies	>3 publications with MASP1 and Lung
Muscle Antibodies	>3 publications with MASP1 and Muscle
Bone Antibodies	>2 publications with MASP1 and Bone
Kidney Antibodies	>2 publications with MASP1 and Kidney
Intestine Antibodies	>1 publications with MASP1 and Intestine
Testis Antibodies	>1 publications with MASP1 and Testis
Brain Antibodies	>1 publications with MASP1 and Brain