Human MCM8 cDNA Clone Expression Plasmid – Cat# MBS1267018

MCM8 cDNA Clone – Minichromosome Maintenance Complex Component 8 (Human)

Name: MCM8 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1267018
Price: 235 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1267018

MBS1267018 is a cDNA clone targeting MCM8. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MCM8, cDNA Clone

Full Product Name

MCM8 cDNA Clone

Product Gene Name

MCM8 cdna clone

Sequence

atggcttttc tttgtgctgc atgtggagaa attcagagct ttcctcttcc agatggaaaa tacagtcttc ccacaaagtg tcctgtgcct gtgtgtcgag gcaggtcatt tactgctctc cgcagctctc ctctcacagt tacgatggac tggcagtcaa tcaaaatcca ggaattgatg tctgatgatc agagagaagc aggtcggatt ccacgaacaa tagaatgtga gcttgttcat gatcttgtgg atagctgtgt cccgggagac acagtgacta ttactggaat tgtcaaagtc tcaaatgcgg aagaaggttc tcgaaataag aatgacaagt gtatgttcct tttgtatatt gaagcaaatt ctattagtaa tagcaaagga cagaaaacaa agagttctga ggatgggtgt aagcatggaa tgttgatgga gttctcactt aaagaccttt atgccatcca agagattcaa gctgaagaaa acctgtttaa actcattgtc aactcgcttt gccctgtcat ttttggtcat gaacttgtta aagcaggttt ggcattagca ctctttggag gaagccagaa atacgcagat gacaaaaaca gaattccaat tcggggagac ccccacatcc ttgttgttgg agatccaggc ctaggaaaaa gtcaaatgct acaggcagcg tgcaatgttg ccccacgtgg cgtgtatgtt tgtggtaaca ccacgaccac ctctggtctg acggtaactc tttcaaaaga tagttcctct ggagattttg ctttggaagc tggtgccctg gtacttggtg atcaaggtat ttgtggaatc gatgaatttg ataagatggg gaatcaacat caagccttgt tggaagccat ggagcagcaa agtattagtc ttgctaaggc tggtgtggtt tgtagccttc ctgcaagaac ttccattatt gctgctgcaa atccagttgg aggacattac aataaagcca aaacagtttc tgagaattta aaaatgggga gtgcactact atccagattt gatttggtct ttatcctgtt agatactcca aatgagcatc atgatcactt actctctgaa catgtgattg caataagagc tggaaagcag agaaccatta gcagtgccac agtagctcgt atgaatagtc aagattcaaa tacttccgta cttgaagtag tttctgagaa gccattatca gaaagactaa aggtggttcc tggagaaaca atagatccca ttccccacca gctattgaga aagtacattg gctatgctcg gcagtatgtg tacccaaggc tatccacaga agctgctcga gttcttcaag atttttacct tgagctccgg aaacagagcc agaggttaaa tagctcacca atcactacca ggcagctgga atctttgatt cgtctgacag aggcacgagc aaggttggaa ttgagagagg aagcaaccaa agaagacgct gaggatatag tggaaattat gaaatatagc atgctaggaa cttactctga tgaatttggg aacctagatt ttgagcgatc ccagcatggt tctggaatga gcaacaggtc aacagcgaaa agatttattt ctgctctcaa caacgttgct gaaagaactt ataataatat atttcaattt catcaacttc ggcagattgc caaagaacta aacattcagg ttgctgattt tgaaaatttt attggatcac taaatgacca gggttacctc ttgaaaaaag gcccaaaagt ttaccagctt caaactatgt aa

Molecular Weight

97,932 Da

OMIM

608187

Vector

pENTR223.1

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of MCM8 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MCM8. It may not necessarily be applicable to this product.

NCBI GI #

39644543

NCBI GeneID

84515

NCBI Accession #

BC008830

UniProt Secondary Accession #

Q495R4; Q495R6; Q495R7; Q86US4; Q969I5; B2RBG7; D3DW08; E7EQU7

UniProt Related Accession #

Q9UJA3

NCBI Official Full Name

Homo sapiens minichromosome maintenance complex component 8, mRNA

NCBI Official Synonym Full Names

minichromosome maintenance 8 homologous recombination repair factor

NCBI Official Symbol

MCM8

NCBI Official Synonym Symbols

POF10; C20orf154; dJ967N21.5

UniProt Protein Name

DNA helicase MCM8

UniProt Synonym Protein Names

Minichromosome maintenance 8

Protein Family

DNA helicase

UniProt Gene Name

MCM8

UniProt Synonym Gene Names

C20orf154

UniProt Entry Name

MCM8_HUMAN

NCBI Protein Information

DNA helicase MCM8

NCBI Summary for MCM8

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the mini-chromosome maintenance proteins is a key component of the pre-replication complex and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the mini-chromosome maintenance proteins. The encoded protein may interact with other mini-chromosome maintenance proteins and play a role in DNA replication. This gene may be associated with length of reproductive lifespan and menopause. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2013]

UniProt Comments for MCM8

MCM8: Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8- MCM9 complex probably acts as a hexameric helicase downstream of the Fanconi anemia proteins BRCA2 and RAD51 and is required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart. May also play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC). Binds chromatin throughout the cell cycle. Belongs to the MCM family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; EC 3.6.4.12

Chromosomal Location of Human Ortholog: 20p12.3

Cellular Component: nucleoplasm; nucleus

Molecular Function: protein binding

Biological Process: DNA replication; female gamete generation; G1/S transition of mitotic cell cycle; male gamete generation; response to DNA damage stimulus

Disease: Premature Ovarian Failure 10

Research Articles on MCM8

1. MCM8, a component of the pre-replication complex, is crucial for gonadal development and maintenance in humans-both males and females. These

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with MCM8 cdna clone

Products by Pathway	Pathway Diagram
Activation Of ATR In Response To Replication Stress Pathway antibodies	Activation Of ATR In Response To Replication Stress Pathway Diagram
Activation Of The Pre-replicative Complex Pathway antibodies	Activation Of The Pre-replicative Complex Pathway Diagram
Assembly Of The Pre-replicative Complex Pathway antibodies	Assembly Of The Pre-replicative Complex Pathway Diagram
CDC6 Association With The ORC:origin Complex Pathway antibodies	CDC6 Association With The ORC:origin Complex Pathway Diagram
CDT1 Association With The CDC6:ORC:origin Complex Pathway antibodies	CDT1 Association With The CDC6:ORC:origin Complex Pathway Diagram
Cell Cycle Pathway antibodies	Cell Cycle Pathway Diagram
Cell Cycle Checkpoints Pathway antibodies	Cell Cycle Checkpoints Pathway Diagram
Cell Cycle, Mitotic Pathway antibodies	Cell Cycle, Mitotic Pathway Diagram
Cell Cycle Pathway antibodies	Cell Cycle Pathway Diagram
DNA Replication Pathway antibodies	DNA Replication Pathway Diagram

Diseases associated with MCM8 cdna clone

Disease Name	Pubmed Publications
Neoplasms Antibodies	>3 publications with MCM8 and Neoplasms
Cardiovascular Diseases Antibodies	>2 publications with MCM8 and Cardiovascular Diseases
Infertility, Female Antibodies	>1 publications with MCM8 and Infertility, Female
Lung Neoplasms Antibodies	>1 publications with MCM8 and Lung Neoplasms
Carcinoma Antibodies	>1 publications with MCM8 and Carcinoma
Liver Neoplasms Antibodies	>1 publications with MCM8 and Liver Neoplasms
Anemia Antibodies	>1 publications with MCM8 and Anemia
Precancerous Conditions Antibodies	>1 publications with MCM8 and Precancerous Conditions

Organs/Tissues associated with MCM8 cdna clone

Organ/Tissue Name	Pubmed Publications
Ovary Antibodies	>2 publications with MCM8 and Ovary
Heart Antibodies	>1 publications with MCM8 and Heart
Liver Antibodies	>1 publications with MCM8 and Liver
Placenta Antibodies	>1 publications with MCM8 and Placenta
Lung Antibodies	>1 publications with MCM8 and Lung