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MERTK cDNA Clone – C-Mer Proto-Oncogene Tyrosine Kinase (Human)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1268126

MBS1268126 is a cDNA clone targeting MERTK. More details

$520 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MERTK, cDNA Clone
Full Product Name
MERTK cDNA Clone
Product Gene Name
MERTK cdna clone
Sequence
ATGAAAATAA ACAATGAAGA GATCGTGTCT GATCCCATCT ACATCGAAGT ACAAGGACTT CCTCACTTTA CTAAGCAGCC TGAGAGCATG AATGTCACCA GAAACACAGC CTTCAACCTC ACCTGTCAGG CTGTGGGCCC GCCTGAGCCC GTCAACATTT TCTGGGTTCA AAACAGTAGC CGTGTTAACG AACAGCCTGA AAAATCCCCC TCCGTGCTAA CTGTTCCAGG CCTGACGGAG ATGGCGGTCT TCAGTTGTGA GGCCCACAAT GACAAAGGGC TGACCGTGTC CAAGGGAGTG CAGATCAACA TCAAAGCAAT TCCCTCCCCA CCAACTGAAG TCAGCATCCG TAACAGCACT GCACACAGCA TTCTGATCTC CTGGGTTCCT GGTTTTGATG GATACTCCCC GTTCAGGAAT TGCAGCATTC AGGTCAAGGA AGCTGATCCG CTGAGTAATG GCTCAGTCAT GATTTTTAAC ACCTCTGCCT TACCACATCT GTACCAAATC AAGCAGCTGC AAGCCCTGGC TAATTACAGC ATTGGTGTTT CCTGCATGAA TGAAATAGGC TGGTCTGCAG TGAGCCCTTG GATTCTAGCC AGCACGACTG AAGGAGCCCC ATCAGTAGCA CCTTTAAATG TCACTGTGTT TCTGAATGAA TCTAGTGATA ATGTGGACAT CAGATGGATG AAGCCTCCGA CTAAGCAGCA GGATGGAGAA CTGGTGGGCT ACCGGATATC CCACGTGTGG CAGAGTGCAG GGATTTCCAA AGAGCTCTTG GAGGAAGTTG GCCAGAATGG CAGCCGAGCT CGGATCTCTG TTCAAGTCCA CAATGCTACG TGCACAGTGA GGATTGCAGC CGTCACCAAA GGGGGAGTTG GGCCCTTCAG TGATCCAGTG AAAATATTTA TCCCTGCACA CGGTTGGGTA GATTATGCCC CCTCTTCAAC TCCGGCGCCT GGCAACGCAG ATCCTGTGCT CATCATCTTT GGCTGCTTTT GTGGATTTAT TTTGATTGGG TTGGTTTTAT ACATCTCCTT GGCCATCAGA AAAAGAGTCC AGGAGACAAA GTTTGGGAAT GCATTCACAG AGGAGGATTC TGAATTAGTG GTGAATTATA TAGCAAAGAA ATCCTTCTGT CGGCGAGCCA TTGAACTTAC CTTACATAGC TTGGGAGTCA GTGAGGAACT ACAAAATAAA CTAGAAGATG TTGTGATTGA CAGGAATCTT CTAATTCTTG GAAAAATTCT GGGTGAAGGA GAGTTTGGGT CTGTAATGGA AGGAAATCTT AAGCAGGAAG ATGGGACCTC TCTGAAAGTG GCAGTGAAGA CCATGAAGTT GGACAACTCT TCGCAGCGGG AGATCGAGGA GTTTCTCAGT GAGGCAGCGT GCATGAAAGA CTTCAGCCAC CCAAATGTCA TTCGACTTCT AGGTGTGTGT ATAGAAATGA GCTCTCAAGG CATCCCAAAG CCCATGGTAA TTTTACCCTT CATGAAATAC GGGGACCTGC ATACTTACTT ACTTTATTCC CGATTGGAGA CAGGACCAAA GCATATTCCT CTGCAGACAC TATTGAAGTT CATGGTGGAT ATTGCCCTGG GAATGGAGTA TCTGAGCAAC AGGAATTTTC TTCATCGAGA TTTAGCTGCT CGAAACTGCA TGTTGCGAGA TGACATGACT GTCTGTGTTG CGGACTTCGG CCTCTCTAAG AAGATTTACA GTGGCGATTA TTACCGCCAA GGCCGCATTG CTAAGATGCC TGTTAAATGG ATCGCCATAG AAAGTCTTGC AGACCGAGTC TACACAAGTA AAAGTGATGT GTGGGCATTT GGCGTGACCA TGTGGGAAAT AGCTACGCGG GGAATGACTC CCTATCCTGG GGTCCAGAAC CATGAGATGT ATGACTATCT TCTCCATGGC CACAGGTTGA AGCAGCCCGA AGACTGCCTG GATGAACTGT ATGAAATAAT GTACTCTTGC TGGAGAACCG ATCCCTTAGA CCGCCCCACC TTTTCAGTAT TGAGGCTGCA GCTAGAAAAA CTCTTAGAAA GTTTGCCTGA CGTTCGGAAC CAAGCAGACG TTATTTACGT CAATACACAG TTGCTGGAGA GCTCTGAGGG CCTGGCCCAG GGCTCCACCC TTGCTCCACT GGACTTGAAC ATCGACCCTG ACTCTATAAT TGCCTCCTGC ACTCCCCGCG CTGCCATCAG TGTGGTCACA GCAGAAGTTC ATGACAGCAA ACCTCATGAA GGACGGTACA TCCTGAATGG GGGCAGTGAG GAATGGGAAG ATCTGACTTC TGCCCCCTCT GCTGCAGTCA CAGCTGAAAA GAACAGTGTT TTACCGGGGG AGAGACTTGT TAGGAATGGG GTCTCCTGGT CCCATTCGAG CATGCTGCCC TTGGGAAGCT CATTGCCCGA TGAACTTTTG TTTGCTGACG ACTCCTCAGA AGGCTCAGAA GTCCTGATGT GA
Molecular Weight
110,249 Da
OMIM
604705
Vector
pENTR223.1 or pUC
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of MERTK cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MERTK. It may not necessarily be applicable to this product.

NCBI GI #
92096109
NCBI GeneID
10461
NCBI Accession #
BC114918
UniProt Secondary Accession #
Q9HBB4
UniProt Related Accession #
Q12866
NCBI Official Full Name
Homo sapiens c-mer proto-oncogene tyrosine kinase, mRNA
NCBI Official Synonym Full Names
MER proto-oncogene, tyrosine kinase
NCBI Official Symbol
MERTK
NCBI Official Synonym Symbols
MER; RP38; c-Eyk; c-mer; Tyro12
UniProt Protein Name
Tyrosine-protein kinase Mer
UniProt Synonym Protein Names
Proto-oncogene c-Mer; Receptor tyrosine kinase MerTK
Protein Family
Tyrosine-protein kinase
UniProt Gene Name
MERTK
UniProt Synonym Gene Names
MER
UniProt Entry Name
MERTK_HUMAN
NCBI Protein Information
tyrosine-protein kinase Mer

NCBI Summary for MERTK

This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). [provided by RefSeq, Jul 2008]
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UniProt Comments for MERTK

Mer: a proto-oncogene receptor tyrosine-protein kinase of the Axl family. Binds several ligands including LGALS3, Tubby, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3

Protein type: Kinase, protein; Membrane protein, integral; EC 2.7.10.1; Protein kinase, tyrosine (receptor); Protein kinase, TK; Oncoprotein; TK group; Axl family

Chromosomal Location of Human Ortholog: 2q14.1

Cellular Component: cytoplasm; extracellular space; integral to plasma membrane; plasma membrane

Molecular Function: protein binding

Biological Process: cell surface receptor linked signal transduction; cell-cell signaling; leukocyte migration; phagocytosis; positive regulation of phagocytosis; protein amino acid phosphorylation

Disease: Retinitis Pigmentosa 38
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Research Articles on MERTK

1. Upon differentiation of these iPSC towards RPE, patient-specific RPE cells exhibited defective phagocytosis, a characteristic phenotype of MERTK deficiency observed in human patients and animal models

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with MERTK cdna clone

 Products by Pathway  Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram

Diseases associated with MERTK cdna clone

 Disease Name  Pubmed Publications
 Retinitis Pigmentosa Antibodies  >38 publications with MERTK and Retinitis Pigmentosa
 Neoplasms Antibodies  >36 publications with MERTK and Neoplasms
 Inflammation Antibodies  >31 publications with MERTK and Inflammation
 Disease Models, Animal Antibodies  >27 publications with MERTK and Disease Models, Animal
 Nervous System Diseases Antibodies  >20 publications with MERTK and Nervous System Diseases
 Death Antibodies  >20 publications with MERTK and Death
 Necrosis Antibodies  >19 publications with MERTK and Necrosis
 Atherosclerosis Antibodies  >13 publications with MERTK and Atherosclerosis
 Nerve Degeneration Antibodies  >10 publications with MERTK and Nerve Degeneration
 Brain Diseases Antibodies  >9 publications with MERTK and Brain Diseases

Organs/Tissues associated with MERTK cdna clone

 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >78 publications with MERTK and Eye
 Blood Antibodies  >63 publications with MERTK and Blood
 Bone Antibodies  >23 publications with MERTK and Bone
 Brain Antibodies  >16 publications with MERTK and Brain
 Lung Antibodies  >10 publications with MERTK and Lung
 Testis Antibodies  >10 publications with MERTK and Testis
 Kidney Antibodies  >7 publications with MERTK and Kidney
 Liver Antibodies  >6 publications with MERTK and Liver
 Muscle Antibodies  >6 publications with MERTK and Muscle
 Embryonic Tissue Antibodies  >5 publications with MERTK and Embryonic Tissue
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