MGST2 cDNA Clone – Microsomal Glutathione S-Transferase 2 (Human)

The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes a protein which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2011]

MGST2: Can catalyze the production of LTC4 from LTA4 and reduced glutathione. Can catalyze the conjugation of 1-chloro-2,4- dinitrobenzene with reduced glutathione. Belongs to the MAPEG family.

Protein type: Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Membrane protein, integral; EC 2.5.1.18; Endoplasmic reticulum; Other Amino Acids Metabolism - glutathione; Xenobiotic Metabolism - metabolism by cytochrome P450; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 4q28.3

Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; intracellular membrane-bound organelle; nuclear envelope; plasma membrane

Molecular Function: glutathione peroxidase activity; glutathione transferase activity; leukotriene-C4 synthase activity

Biological Process: glutathione biosynthetic process; leukotriene biosynthetic process; xenobiotic metabolic process