Human MMP13 cDNA Clone Expression Plasmid – Cat# MBS1270816

MMP13 cDNA Clone – Matrix Metallopeptidase 13 (Collagenase 3) (Human)

Name: MMP13 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1270816
Price: 235 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1270816

MBS1270816 is a cDNA clone targeting MMP13. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MMP13, cDNA Clone

Full Product Name

MMP13 cDNA Clone

Product Gene Name

MMP13 cdna clone

Sequence

atgcatccag gggtcctggc tgccttcctc ttcttgagct ggactcattg tcgggccctg ccccttccca gtggtggtga tgaagatgat ttgtctgagg aagacctcca gtttgcagag cgctacctga gatcatacta ccatcctaca aatctcgcgg gaatcctgaa ggagaatgca gcaagctcca tgactgagag gctccgagaa atgcagtctt tcttcggctt agaggtgact ggcaaacttg acgataacac cttagatgtc atgaaaaagc caagatgcgg ggttcctgat gtgggtgaat acaatgtttt ccctcgaact cttaaatggt ccaaaatgaa tttaacctac agaattgtga attacacccc tgatatgact cattctgaag tcgaaaaggc attcaaaaaa gccttcaaag tttggtccga tgtaactcct ctgaatttta ccagacttca cgatggcatt gctgacatca tgatctcttt tggaattaag gagcatggcg acttctaccc atttgatggg ccctctggcc tgctggctca tgcttttcct cctgggccaa attatggagg agatgcccat tttgatgatg atgaaacctg gacaagtagt tccaaaggct acaacttgtt tcttgttgct gcgcatgagt tcggccactc cttaggtctt gaccactcca aggaccctgg agcactcatg tttcctatct acacctacac cggcaaaagc cactttatgc ttcctgatga cgatgtacaa gggatccagt ctctctatgg tccaggagat gaagacccca accctaaaca tccaaaaacg ccagacaaat gtgacccttc cttatccctt gatgccatta ccagtctccg aggagaaaca atgatcttta aagacagatt cttctggcgc ctgcatcctc agcaggttga tgcggagctg tttttaacga aatcattttg gccagaactt cccaaccgta ttgatgctgc atatgagcac ccttctcatg acctcatctt catcttcaga ggtagaaaat tttgggctct taatggttat gacattctgg aaggttatcc caaaaaaata tctgaactgg gtcttccaaa agaagttaag aagataagtg cagctgttca ctttgaggat acaggcaaga ctctcctgtt ctcaggaaac caggtctgga gatatgatga tactaaccat attatggata aagactatcc gagactaata gaagaagact tcccaggaat tggtgataaa gtagatgctg tctatgagaa aaatggttat atctattttt tcaacggacc catacagttt gaatacagca tctggagtaa ccgtattgtt cgcgtcatgc cagcaaattc cattttgtgg tgttaa

Molecular Weight

53,820 Da

OMIM

250400

Vector

pENTR223.1

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of MMP13 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MMP13. It may not necessarily be applicable to this product.

NCBI GI #

45768658

NCBI GeneID

4322

NCBI Accession #

BC067522

UniProt Secondary Accession #

Q6NWN6; A8K846; B2RCZ3

UniProt Related Accession #

P45452

NCBI Official Full Name

Homo sapiens matrix metallopeptidase 13 (collagenase 3), mRNA

NCBI Official Synonym Full Names

matrix metallopeptidase 13

NCBI Official Symbol

MMP13

NCBI Official Synonym Symbols

CLG3; MDST; MANDP1; MMP-13

UniProt Protein Name

Collagenase 3

UniProt Synonym Protein Names

Matrix metalloproteinase-13; MMP-13

Protein Family

Collagenase

UniProt Gene Name

MMP13

UniProt Synonym Gene Names

MMP-13

UniProt Entry Name

MMP13_HUMAN

NCBI Protein Information

collagenase 3

NCBI Summary for MMP13

This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. Mutations in this gene are associated with metaphyseal anadysplasia. This gene is part of a cluster of MMP genes on chromosome 11. [provided by RefSeq, Jan 2016]

UniProt Comments for MMP13

MMP13: Degrades collagen type I. Does not act on gelatin or casein. Could have a role in tumoral process. Defects in MMP13 are the cause of spondyloepimetaphyseal dysplasia Missouri type (SEMD-MO). A bone disease characterized by moderate to severe metaphyseal changes, mild epiphyseal involvement, rhizomelic shortening of the lower limbs with bowing of the femora and/or tibiae, coxa vara, genu varum and pear-shaped vertebrae in childhood. Epimetaphyseal changes improve with age. Defects in MMP13 are the cause of metaphyseal anadysplasia type 1 (MANDP1). Metaphyseal anadysplasia consists of an abnormal bone development characterized by severe skeletal changes that, in contrast with the progressive course of most other skeletal dysplasias, resolve spontaneously with age. Clinical characteristics are evident from the first months of life and include slight shortness of stature and a mild varus deformity of the legs. Patients attain a normal stature in adolescence and show improvement or complete resolution of varus deformity of the legs and rhizomelic micromelia. Belongs to the peptidase M10A family.

Protein type: Secreted; EC 3.4.24.-; Protease; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11q22.3

Cellular Component: extracellular region

Molecular Function: calcium ion binding; collagen binding; metalloendopeptidase activity; serine-type endopeptidase activity; zinc ion binding

Biological Process: collagen catabolic process; extracellular matrix disassembly

Disease: Spondyloepimetaphyseal Dysplasia, Missouri Type

Research Articles on MMP13

1. SENP2 inhibits MMP13 expression in BC cells through de-SUMOylation of TBL1/TBLR1, which inhibits nuclear translocation of beta-catenin.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with MMP13 cdna clone

Products by Pathway	Pathway Diagram
AGE/RAGE Pathway antibodies	AGE/RAGE Pathway Diagram
Activation Of Matrix Metalloproteinases Pathway antibodies	Activation Of Matrix Metalloproteinases Pathway Diagram
Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies	Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram
Collagen Formation Pathway antibodies	Collagen Formation Pathway Diagram
Degradation Of Collagen Pathway antibodies	Degradation Of Collagen Pathway Diagram
Degradation Of Collagen Pathway antibodies	Degradation Of Collagen Pathway Diagram
Degradation Of The Extracellular Matrix Pathway antibodies	Degradation Of The Extracellular Matrix Pathway Diagram
Degradation Of The Extracellular Matrix Pathway antibodies	Degradation Of The Extracellular Matrix Pathway Diagram
Endochondral Ossification Pathway antibodies	Endochondral Ossification Pathway Diagram
Extracellular Matrix Organization Pathway antibodies	Extracellular Matrix Organization Pathway Diagram

Diseases associated with MMP13 cdna clone

Disease Name	Pubmed Publications
Inflammation Antibodies	>146 publications with MMP13 and Inflammation
Necrosis Antibodies	>129 publications with MMP13 and Necrosis
Disease Models, Animal Antibodies	>120 publications with MMP13 and Disease Models, Animal
Fibrosis Antibodies	>82 publications with MMP13 and Fibrosis
Liver Diseases Antibodies	>52 publications with MMP13 and Liver Diseases
Breast Neoplasms Antibodies	>40 publications with MMP13 and Breast Neoplasms
Lung Diseases Antibodies	>30 publications with MMP13 and Lung Diseases
Heart Diseases Antibodies	>26 publications with MMP13 and Heart Diseases
Drug Toxicity Antibodies	>21 publications with MMP13 and Drug Toxicity
Liver Cirrhosis, Experimental Antibodies	>20 publications with MMP13 and Liver Cirrhosis, Experimental