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MR1 cDNA Clone – Major Histocompatibility Complex, Class I-Related (Human)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1273789

MBS1273789 is a cDNA clone targeting MR1. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MR1, cDNA Clone
Full Product Name
MR1 cDNA Clone
Product Gene Name
MR1 cdna clone
Sequence
atgggggaac tgatggcgtt cctgttacct ctcatcattg tgttaatggt gaagcacagc gattcccgga cgcactctct gagatatttt cgcctgggcg tttcggatcc catccatggg gtccctgaat ttatttcggt tgggtacgtg gactcgcacc ctatcaccac atatgacagt gtcactcggc agaaggagcc acgggcccca tggatggcag agaacctcgc gcctgatcac tgggagaggt acactcagct gctgaggggc tggcagcaga tgttcaaggt ggaactgaag cgcctacaga ggcactacaa tcactcagat aatgtggctc acaccatcaa gcaggcatgg gaggccaatc agcatgagtt gctgtatcaa aagaattggc tggaagaaga atgtattgcc tggctaaaga gattcctgga gtatgggaaa gacaccctac aaagaacaga gcccccactg gtcagagtaa atcgcaaaga aacttttcca ggggttacag ctctcttctg caaagctcat ggcttttacc ccccagaaat ttacatgaca tggatgaaaa acggggaaga aattgtccaa gaaattgatt atggagacat tcttcccagt ggggatggaa cctatcaggc gtgggcatca attgagcttg atcctcagag cagcaacctt tactcctgtc atgtggagca ctgcggtgtc cacatggttc ttcaggtccc ccaggaatca gaaactatcc ctcttgtgat gaaagctgtc tctgggtcca ttgtccttgt cattgtgctg gctggagttg gtgttctagt ctggagaaga aggccccgag agcaaaatgg agccatctac cttccaacac cagatcgatg a
Molecular Weight
25,190 Da
OMIM
600764
Vector
pENTR223.1
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of MR1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MR1. It may not necessarily be applicable to this product.

NCBI GI #
15214701
NCBI GeneID
3140
NCBI Accession #
BC012485
UniProt Secondary Accession #
O97985; O97986; Q53GM1; Q95HB8; Q9MY23; Q9NPL2; Q9TQB3; Q9TQB9; Q9TQK3; A8K2V9; B4E3B1
UniProt Related Accession #
Q95460
NCBI Official Full Name
Homo sapiens major histocompatibility complex, class I-related, mRNA
NCBI Official Synonym Full Names
major histocompatibility complex, class I-related
NCBI Official Symbol
MR1
NCBI Official Synonym Symbols
HLALS
UniProt Protein Name
Major histocompatibility complex class I-related gene protein
UniProt Synonym Protein Names
Class I histocompatibility antigen-like protein
Protein Family
Major histocompatibility complex class I-related gene protein
UniProt Gene Name
MR1
UniProt Synonym Gene Names
MHC class I-related gene protein
UniProt Entry Name
HMR1_HUMAN
NCBI Protein Information
major histocompatibility complex class I-related gene protein

NCBI Summary for MR1

MAIT (mucosal-associated invariant T-cells) lymphocytes represent a small population of T-cells primarily found in the gut. The protein encoded by this gene is an antigen-presenting molecule that presents metabolites of microbial vitamin B to MAITs. This presentation may activate the MAITs to regulate the amounts of specific types of bacteria in the gut. Several transcript variants encoding different isoforms have been found for this gene, and a pseudogene of it has been detected about 36 kbp upstream on the same chromosome. [provided by RefSeq, Jul 2015]
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UniProt Comments for MR1

MR1: Has antigen presentation function. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT cells are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand- dependent. Belongs to the MHC class I family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q25.3

Cellular Component: endoplasmic reticulum; plasma membrane

Molecular Function: antigen binding; MHC class I receptor activity; protein binding

Biological Process: antigen processing and presentation; immune response
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Research Articles on MR1

1. endosome-mediated trafficking of MR1 allows for selective sampling of the intracellular environment

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with MR1 cdna clone

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >28 publications with MR1 and Neoplasms
 Immune System Diseases Antibodies  >24 publications with MR1 and Immune System Diseases
 Nervous System Diseases Antibodies  >22 publications with MR1 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >17 publications with MR1 and Cardiovascular Diseases
 Inflammation Antibodies  >13 publications with MR1 and Inflammation
 Necrosis Antibodies  >13 publications with MR1 and Necrosis
 Brain Diseases Antibodies  >11 publications with MR1 and Brain Diseases
 Heart Diseases Antibodies  >11 publications with MR1 and Heart Diseases
 Fibrosis Antibodies  >10 publications with MR1 and Fibrosis
 Drug Toxicity Antibodies  >8 publications with MR1 and Drug Toxicity

Organs/Tissues associated with MR1 cdna clone

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >124 publications with MR1 and Blood
 Skin Antibodies  >27 publications with MR1 and Skin
 Liver Antibodies  >20 publications with MR1 and Liver
 Intestine Antibodies  >20 publications with MR1 and Intestine
 Kidney Antibodies  >18 publications with MR1 and Kidney
 Muscle Antibodies  >15 publications with MR1 and Muscle
 Bone Antibodies  >15 publications with MR1 and Bone
 Spleen Antibodies  >14 publications with MR1 and Spleen
 Lymph Node Antibodies  >12 publications with MR1 and Lymph Node
 Lung Antibodies  >12 publications with MR1 and Lung
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