Human MSH3 cDNA Clone Expression Plasmid – Cat# MBS1268517

MSH3 cDNA Clone – Muts Homolog 3 (E. Coli) (Human)

Name: MSH3 cDNA Clone; Muts Homolog 3 (E. Coli); Human; MyBioSource
Brand: MyBioSource
SKU: MBS1268517
Price: 1425 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1268517

MBS1268517 is a cDNA clone targeting MSH3. More details

$1425 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MSH3, cDNA Clone

Full Product Name

MSH3 cDNA Clone

Product Gene Name

MSH3 cdna clone

Sequence

atgtctcgcc ggaagcctgc gtcgggcggc ctcgctgcct ccagctcagc ccctgcgagg caagcggttt tgagccgatt cttccagtct acgggaagcc tgaaatccac ctcctcctcc acaggtgcag ccgaccaggt ggaccctggc gctgcagcgg ctgcagcggc cgcagcggcc acagcgcccc cagcgccccc agctcccgcc ttcccgcccc agctgccgcc gcacatagct acagaaattg acagaagaaa gaagagacca ttggaaaatg atgggcctgt taaaaagaaa gtaaagaaag tccaacaaaa ggaaggagga agtgatctgg gaatgtctgg caactctgag ccaaagaaat gtctgaggac caggaatgtt tcaaagtctc tggaaaaatt gaaagaattc tgctgcgatt ctgcccttcc tcaaagtaga gtccagacag aatctctgca ggagagattt gcagttctgc caaaatgtac tgattttgat gatatcagtc ttctacacgc aaagaatgca gtttcttctg aagattcgaa acgtcaaatt aatcaaaagg acacaacact ttttgatctc agtcagtttg gatcatcaaa tacaagtcat gaaaatttac agaaaactgc ttccaaatca gctaacaaac ggtccaaaag catctatacg ccgctagaat tacaatacat agaaatgaag cagcagcaca aagatgcagt tttgtgtgtg gaatgtggat ataagtatag attctttggg gaagatgcag agattgcagc ccgagagctc aatatttatt gccatttaga tcacaacttt atgacagcaa gtatacctac tcacagactg tttgttcatg tacgccgcct ggtggcaaaa ggatataagg tgggagttgt gaagcaaact gaaactgcag cattaaaggc cattggagac aacagaagtt cactcttttc ccggaaattg actgcccttt atacaaaatc tacacttatt ggagaagatg tgaatcccct aatcaagctg gatgatgctg taaatgttga tgagataatg actgatactt ctaccagcta tcttctgtgc atctctgaaa ataaggaaaa tgttagggac aaaaaaaagg gcaacatttt tattggcatt gtgggagtgc agcctgccac aggcgaggtt gtgtttgata gtttccagga ctctgcttct cgttcagagc tagaaacccg gatgtcaagc ctgcagccag tagagctgct gcttccttcg gccttgtccg agcaaacaga ggcgctcatc cacagagcca catctgttag tgtgcaggat gacagaattc gagtcgaaag gatggataac atttattttg aatacagcca tgctttccag gcagttacag agttttatgc aaaagataca gttgacatca aaggttctca aattatttct ggcattgtta acttagagaa gcctgtgatt tgctctttgg ctgccatcat aaaatacctc aaagaattca acttggaaaa gatgctctcc aaacctgaga attttaaaca gctatcaagt aaaatggaat ttatgacaat taatggaaca acattaagga atctggaaat cctacagaat cagactgata tgaaaaccaa aggaagtttg ctgtgggttt tagaccacac taaaacttca tttgggagac ggaagttaaa gaagtgggtg acccagccac tccttaaatt aagggaaata aatgcccggc ttgatgctgt atcggaagtt ctccattcag aatctagtgt gtttggtcag atagaaaatc atctacgtaa attgcccgac atagagaggg gactctgtag catttatcac aaaaaatgtt ctacccaaga gttcttcttg attgtcaaaa ctttatatca cctaaagtca gaatttcaag caataatacc tgctgttaat tcccacattc agtcagactt gctccggacc gttattttag aaattcctga actcctcagt ccagtggagc attacttaaa gatactcaat gaacaagctg ccaaagttgg ggataaaact gaattattta aagacctttc tgacttccct ttaataaaaa agaggaagga tgaaattcaa ggtgttattg acgagatccg aatgcatttg caagaaatac gaaaaatact aaaaaatcct tctgcacaat atgtgacagt atcaggacag gagtttatga tagaaataaa gaactctgct gtatcttgta taccaactga ttgggtaaag gttggaagca caaaagctgt gagccgcttt cactctcctt ttattgtaga aaattacaga catctgaatc agctccggga gcagctagtc cttgactgca gtgctgaatg gcttgatttt ctagagaaat tcagtgaaca ttatcactcc ttgtgtaaag cagtgcatca cctagcaact gttgactgca ttttctccct ggccaaggtc gctaagcaag gagattactg cagaccaact gtacaagaag aaagaaaaat tgtaataaaa aatggaaggc accctgtgat tgatgtgttg ctgggagaac aggatcaata tgtcccaaat aatacagatt tatcagagga ctcagagaga gtaatgataa ttaccggacc aaacatgggt ggaaagagct cctacataaa acaagttgca ttgattacca tcatggctca gattggctcc tatgttcctg cagaagaagc gacaattggg attgtggatg gcattttcac aaggatgggt gctgcagaca atatatataa aggacggagt acatttatgg aagaactgac tgacacagca gaaataatca gaaaagcaac atcacagtcc ttggttatct tggatgaact aggaagaggg acgagcactc atgatggaat tgccattgcc tatgctacac ttgagtattt catcagagat gtgaaatcct taaccctgtt tgtcacccat tatccgccag tttgtgaact agaaaaaaat tactcacacc aggtggggaa ttaccacatg ggattcttgg tcagtgagga tgaaagcaaa ctggatccag gcacagcaga acaagtccct gattttgtca ccttccttta ccaaataact agaggaattg cagcaaggag ttatggatta aatgtggcta aactagcaga tgttcctgga gaaattttga agaaagcagc tcacaagtca aaagagctgg aaggattaat aaatacgaaa agaaagagac tcaagtattt tgcaaagtta tggacgatgc ataatgcaca agacctgcag aagtggacag aggagttcaa catggaagaa acacagactt ctcttcttca ttaa

Molecular Weight

127,412 Da

OMIM

600887

Vector

Please Inquire

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of MSH3 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MSH3. It may not necessarily be applicable to this product.

NCBI GI #

120660369

NCBI GeneID

4437

NCBI Accession #

BC130434

UniProt Secondary Accession #

Q6PJT5; Q86UQ6; Q92867; A1L480; A1L482; A6NMM6

UniProt Related Accession #

P20585

NCBI Official Full Name

Homo sapiens mutS homolog 3 (E. coli), mRNA

NCBI Official Synonym Full Names

mutS homolog 3

NCBI Official Symbol

MSH3

NCBI Official Synonym Symbols

DUP; MRP1

UniProt Protein Name

DNA mismatch repair protein Msh3

UniProt Synonym Protein Names

Divergent upstream protein; DUP; Mismatch repair protein 1; MRP1

Protein Family

DNA mismatch repair protein

UniProt Gene Name

MSH3

UniProt Synonym Gene Names

DUC1; DUG; hMSH3; DUP; MRP1

UniProt Entry Name

MSH3_HUMAN

NCBI Protein Information

DNA mismatch repair protein Msh3

NCBI Summary for MSH3

The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat is present 6 times in the reference genome sequence and 3-7 repeats have been reported. Defects in this gene are a cause of susceptibility to endometrial cancer. [provided by RefSeq, Mar 2011]

UniProt Comments for MSH3

MSH3: Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion- deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. Defects in MSH3 are a cause of susceptibility to endometrial cancer (ENDMC). Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.

Protein type: DNA repair, damage

Chromosomal Location of Human Ortholog: 5q11-q12

Cellular Component: membrane; MutSbeta complex; nuclear chromosome; nucleoplasm

Molecular Function: damaged DNA binding; dinucleotide insertion or deletion binding; dinucleotide repeat insertion binding; enzyme binding; guanine/thymine mispair binding; mismatched DNA binding; oxidized purine DNA binding; protein binding; protein homodimerization activity; single guanine insertion binding; single-stranded DNA binding

Biological Process: DNA repair; maintenance of DNA repeat elements; meiotic mismatch repair; meiotic recombination; mismatch repair; negative regulation of DNA recombination; positive regulation of helicase activity

Disease: Endometrial Cancer

Research Articles on MSH3

1. The mismatch-binding protein MutS beta, a heterodimer of MSH2 and MSH3, activates ATR in response to DNA double-strand breaks.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with MSH3 cdna clone

Products by Pathway	Pathway Diagram
Colorectal Cancer Pathway antibodies	Colorectal Cancer Pathway Diagram
Colorectal Cancer Pathway antibodies	Colorectal Cancer Pathway Diagram
Mismatch Repair Pathway antibodies	Mismatch Repair Pathway Diagram
Mismatch Repair Pathway antibodies	Mismatch Repair Pathway Diagram
Pathways In Cancer antibodies	Pathways In Cancer Diagram

Diseases associated with MSH3 cdna clone

Disease Name	Pubmed Publications
Neoplasms Antibodies	>207 publications with MSH3 and Neoplasms
Adenocarcinoma Antibodies	>25 publications with MSH3 and Adenocarcinoma
Nervous System Diseases Antibodies	>19 publications with MSH3 and Nervous System Diseases
Lung Neoplasms Antibodies	>12 publications with MSH3 and Lung Neoplasms
Immune System Diseases Antibodies	>11 publications with MSH3 and Immune System Diseases
Drug Toxicity Antibodies	>11 publications with MSH3 and Drug Toxicity
Liver Neoplasms Antibodies	>9 publications with MSH3 and Liver Neoplasms
Lymphoma Antibodies	>9 publications with MSH3 and Lymphoma
Neoplasms, Experimental Antibodies	>8 publications with MSH3 and Neoplasms, Experimental
Neoplasm Metastasis Antibodies	>8 publications with MSH3 and Neoplasm Metastasis

Organs/Tissues associated with MSH3 cdna clone

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>38 publications with MSH3 and Blood
Stomach Antibodies	>20 publications with MSH3 and Stomach
Brain Antibodies	>19 publications with MSH3 and Brain
Intestine Antibodies	>18 publications with MSH3 and Intestine
Skin Antibodies	>17 publications with MSH3 and Skin
Liver Antibodies	>17 publications with MSH3 and Liver
Lung Antibodies	>16 publications with MSH3 and Lung
Kidney Antibodies	>14 publications with MSH3 and Kidney
Lymph Node Antibodies	>8 publications with MSH3 and Lymph Node
Lymph Antibodies	>8 publications with MSH3 and Lymph