Human MTHFD1L cDNA Clone Expression Plasmid – Cat# MBS1272387

MTHFD1L cDNA Clone – Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 1-Like (Human)

Name: MTHFD1L cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1272387
Price: 830 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1272387

MBS1272387 is a cDNA clone targeting MTHFD1L. More details

$830 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MTHFD1L, cDNA Clone

Full Product Name

MTHFD1L cDNA Clone

Product Gene Name

MTHFD1L cdna clone

Sequence

atgacaatga gcatccagtg gaaaacacgc cagcttcaaa gcaagcttca cgaggctgac attgtggtcc taggctcacc taagccagaa gagattcccc ttacttggat acaaccagga actactgttc tcaactgctc ccatgacttc ctgtcaggga aggttgggtg tggctctcca agaatacatt ttggtggact cattgaggaa gatgatgtga ttctccttgc tgcagctctg cgaattcaga acatggtcag tagtggaagg agatggcttc gtgaacagca gcacaggcgg tggagacttc actgcttgaa acttcagcct ctctcccctg tgccaagtga cattgagatt tcaagaggac aaactccaaa agctgtggat gtccttgcca aggagattgg attgcttgca gatgaaattg aaatctatgg caaaagcaaa gccaaagtac gtttgtccgt gctagaaagg ttaaaggatc aagcagatgg aaaatacgtc ttagttgctg ggatcacacc cacccctctt ggagaaggga agagcacagt caccatcggg cttgtgcagg ctctgaccgc acacctgaat gtcaactcct ttgcctgctt gaggcagcct tcccaaggac cgacgtttgg agtgaaagga ggagccgcgg gtggtggata tgcccaggtc atccccatgg aggagttcaa ccttcacttg actggagaca tccacgccat caccgctgcc aataacttgc tggctgccgc catcgacacg aggattcttc atgaaaacac gcaaacagat aaggctctgt ataatcggct ggttccttta gtgaatggtg tcagagaatt ttcagaaatt cagcttgctc ggctaaaaaa actgggaata aataagactg atccgagcac actgacagaa gaggaagtga gtaaatttgc ccgtctcgac atcgacccat ctaccatcac gtggcagaga gtattggata caaatgaccg atttctacga aaaataacca tcgggcaggg aaacacagag aagggccatt accggcaggc gcagtttgac atcgcagtgg ccagcgagat catggcggtg ctggccctga cggacagcct cgcagacatg aaggcacggc tgggaaggat ggtggtggcc agtgacaaaa gcgggcagcc tgtgacagca gatgatttgg gggtgacagg tgctttgaca gttttgatga aagatgcaat aaaaccaaac ctgatgcaga ccctggaagg gacacctgtg ttcgtgcatg cgggcccttt tgctaacatt gctcacggca actcttcagt gttggctgat aaaattgccc tgaaactggt tggtgaagaa ggatttgtag tgaccgaagc tggctttggt gctgacatcg gaatggagaa attcttcaac atcaagtgcc gagcttccgg cttggtgccc aacgtggttg tgttagtggc aacggtgcga gctctgaaga tgcatggagg cgggccaagt gtaacggctg gtgttcctct taagaaagaa tatacagagg agaacatcca gctggtggca gacggctgct gtaacctcca gaagcaaatt cagatcactc agctctttgg ggttcccgtt gtggtggctc tgaatgtctt caagaccgac acccgcgctg agattgactt ggtgtgtgag cttgcaaagc gggctggtgc ctttgatgca gtcccctgct atcactggtc ggttggtgga aaaggatcgg tggacttggc tcgggctgtg agagaggctg cgagtaaaag aagccgattc cagttcctgt atgatgttca ggttccaatt gtggacaaga taaggaccat tgctcaggct gtctatggag ccaaagatat tgaactctct cctgaggcac aagccaaaat agatcgttac actcaacagg gttttggaaa tttgcccatc tgcatggcaa agacccacct ttctctatct caccaacctg acaaaaaagg tgtgccaagg gacttcatct tacctatcag tgacgtccgg gccagcatag gcgctgggtt catttaccct ttggtcggaa cgatgagcac catgccagga ctgcccaccc ggccctgctt ttatgacata gatcttgata ccgaaacaga acaagttaaa ggcttgttct aa

Molecular Weight

29,804 Da

OMIM

611427

Vector

Please Inquire

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of MTHFD1L cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MTHFD1L. It may not necessarily be applicable to this product.

NCBI GI #

17028347

NCBI GeneID

25902

NCBI Accession #

BC017477

UniProt Secondary Accession #

Q2TBF3; Q8WVW0; Q96HG8; Q9H789; Q9UFU8

UniProt Related Accession #

Q6UB35

NCBI Official Full Name

Homo sapiens methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like, mRNA

NCBI Official Synonym Full Names

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like

NCBI Official Symbol

MTHFD1L

NCBI Official Synonym Symbols

FTHFSDC1; MTC1THFS; dJ292B18.2

UniProt Protein Name

Monofunctional C1-tetrahydrofolate synthase, mitochondrial

UniProt Synonym Protein Names

Formyltetrahydrofolate synthetase

Protein Family

Monofunctional C1-tetrahydrofolate synthase

UniProt Gene Name

MTHFD1L

UniProt Synonym Gene Names

FTHFSDC1

UniProt Entry Name

C1TM_HUMAN

NCBI Protein Information

monofunctional C1-tetrahydrofolate synthase, mitochondrial

NCBI Summary for MTHFD1L

The protein encoded by this gene is involved in the synthesis of tetrahydrofolate (THF) in the mitochondrion. THF is important in the de novo synthesis of purines and thymidylate and in the regeneration of methionine from homocysteine. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011]

UniProt Comments for MTHFD1L

MTHFD1L: May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ligase; Carbohydrate Metabolism - glyoxylate and dicarboxylate; EC 6.3.4.3; Mitochondrial; Cofactor and Vitamin Metabolism - one carbon pool by folate

Chromosomal Location of Human Ortholog: 6q25.1

Cellular Component: cytosol; membrane; mitochondrial matrix; mitochondrion

Molecular Function: ATP binding; formate-tetrahydrofolate ligase activity; methenyltetrahydrofolate cyclohydrolase activity; methylenetetrahydrofolate dehydrogenase (NADP+) activity; protein homodimerization activity

Biological Process: embryonic neurocranium morphogenesis; embryonic viscerocranium morphogenesis; folic acid and derivative metabolic process; folic acid metabolic process; formate metabolic process; neural tube closure; one-carbon compound metabolic process; tetrahydrofolate metabolic process

Research Articles on MTHFD1L

1. rs6922269 variant at MTHFD1L gene could be an important prognostic factor for cardiovascular mortality in patients after ACS.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with MTHFD1L cdna clone

Products by Pathway	Pathway Diagram
C1-unit Interconversion, Eukaryotes Pathway antibodies	C1-unit Interconversion, Eukaryotes Pathway Diagram
C1-unit Interconversion, Eukaryotes Pathway antibodies	C1-unit Interconversion, Eukaryotes Pathway Diagram
One Carbon Metabolism Pathway antibodies	One Carbon Metabolism Pathway Diagram
One Carbon Pool By Folate Pathway antibodies	One Carbon Pool By Folate Pathway Diagram
One Carbon Pool By Folate Pathway antibodies	One Carbon Pool By Folate Pathway Diagram

Diseases associated with MTHFD1L cdna clone

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>7 publications with MTHFD1L and Nervous System Diseases
Brain Diseases Antibodies	>5 publications with MTHFD1L and Brain Diseases
Congenital Abnormalities Antibodies	>3 publications with MTHFD1L and Congenital Abnormalities
Pain Antibodies	>1 publications with MTHFD1L and Pain
Breast Neoplasms Antibodies	>1 publications with MTHFD1L and Breast Neoplasms
Neoplasms Antibodies	>1 publications with MTHFD1L and Neoplasms

Organs/Tissues associated with MTHFD1L cdna clone

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>4 publications with MTHFD1L and Blood
Heart Antibodies	>3 publications with MTHFD1L and Heart
Embryonic Tissue Antibodies	>2 publications with MTHFD1L and Embryonic Tissue
Liver Antibodies	>1 publications with MTHFD1L and Liver
Brain Antibodies	>1 publications with MTHFD1L and Brain