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MTHFS cDNA Clone – 5-Formyltetrahydrofolate Cyclo-Ligase Isoform a

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS200780

MTHFS an enzyme that catalyzes the conversion of 5-formyltetrahydrofolate to 5, 10-methenyltetrahydrofolate, a precursor of reduced folates involved in 1-carbon metabolism. An increased activity of the encoded protein can result in an increased folate… More details

$245 / 0.01 mg +1 FREE 8GB USB
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
MTHFS, cDNA Clone
Full Product Name
MTHFS
Product Gene Name
MTHFS cdna clone
Product Synonym Names
HsT19268
Sequence
Nucleotide Sequence: ATGGCGGCGG CAGCGGTGAG CAGCGCCAAG CGGAGCCTGC GGGGAGAGCT GAAGCAGCGT CTGCGGGCGA TGAGTGCCGA GGAGCGGCTA CGCCAGTCCC GCGTACTGAG CCAGAAGGTG ATTGCCCACA GTGAGTATCA AAAGTCCAAA AGAATTTCCA TCTTTCTGAG CATGCAAGAT GAAATTGAGA CAGAAGAGAT CATCAAGGAC ATTTTCCAAC GAGGCAAAAT CTGCTTCATC CCTCGGTACC GGTTCCAGAG CAATCACATG GATATGGTGA GAATAGAATC ACCAGAGGAA ATTTCTTTAC TTCCCAAAAC ATCCTGGAAT ATCCCTCAGC CTGGTGAGGG TGATGTTCGG GAGGAGGCCT TGTCCACAGG GGGACTTGAT CTCATCTTCA TGCCAGGCCT TGGGTTTGAC AAACATGGCA ACCGACTGGG GAGGGGCAAG GGCTACTATG ATGCCTATCT GAAGCGCTGT TTGCAGCATC AGGAAGTGAA GCCCTACACC CTGGCGTTGG CTTTCAAAGA ACAGATTTGC CTCCAGGTCC CAGTGAATGA AAACGACATG AAGGTAGATG AAGTCCTTTA CGAAGACTCG TCAACAGCTT AA

Translatio n Sequence: MAAAAVSSAK RSLRGELKQR LRAMSAEERL RQSRVLSQKV IAHSEYQKSK RISIFLSMQD EIETEEIIKD IFQRGKICFI PRYRFQSNHM DMVRIESPEE ISLLPKTSWN IPQPGEGDVR EEALSTGGLD LIFMPGLGFD KHGNRLGRGK GYYDAYLKRC LQHQEVKPYT LALAFKEQIC LQVPVNENDM KVDEVLYEDS STA
Form/Format
Lyophilized
Preparation and Storage
Store the plasmid at -20 degree C.
OMIM
604197
3D Structure
ModBase 3D Structure for P49914
Species
Human
Chromosome Location
15q25.1
OMIM Reference Number
604197
cDNA Size
612bp
Vector Description
This shuttle vector contains the complete ORF. It is inseted BamH I to Xho I. The gene insert contains multiple cloning sites which can be used to easily cut and transfer the gene and recombination site into your expression vector.
Vector
(puc19-derived cloning vector)
Preparation Before Usage
1. Centrifuge at 7000rpm for 1 minute. 2. Carefully open the vial and add 100ul of sterile water to dissolve the DNA. Each tube contains approximately 10ug of lyophilized plasmid.

Product Categories/Family for MTHFS cdna clone

Metabolism; Signal Transduction

Other Notes

Small volumes of MTHFS cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MTHFS purchase

MBS200780 is a cDNA clone targeting MTHFS.

Additional Details

NCBI/Uniprot data below describe general gene information for MTHFS. It may not necessarily be applicable to this product.

NCBI GI #
5453746
NCBI GeneID
10588
NCBI Accession #
NP_006432.1
UniProt Primary Accession #
P49914
UniProt Related Accession #
P49914
GenBank Nucleotide #
NM_006441.3
NCBI Official Full Name
5-formyltetrahydrofolate cyclo-ligase isoform a
NCBI Official Synonym Full Names
methenyltetrahydrofolate synthetase
NCBI Official Symbol
MTHFS
NCBI Official Synonym Symbols
NEDMEHM; HsT19268
UniProt Protein Name
5-formyltetrahydrofolate cyclo-ligase
UniProt Synonym Protein Names
5,10-methenyl-tetrahydrofolate synthetase; MTHFS; Methenyl-THF synthetase
Protein Family
5-formyltetrahydrofolate cyclo-ligase
UniProt Gene Name
MTHFS
UniProt Synonym Gene Names
MTHFS; Methenyl-THF synthetase
UniProt Entry Name
MTHFS_HUMAN
NCBI Protein Information
5-formyltetrahydrofolate cyclo-ligase

NCBI Summary for MTHFS

The protein encoded by this gene is an enzyme that catalyzes the conversion of 5-formyltetrahydrofolate to 5,10-methenyltetrahydrofolate, a precursor of reduced folates involved in 1-carbon metabolism. An increased activity of the encoded protein can result in an increased folate turnover rate and folate depletion. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
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UniProt Comments for MTHFS

Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10-methenyltetrahydrofolate.
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Research Articles on MTHFS

1. The intronic Single nucleotide polymorphism in MTHFS had no significant effect on the risk of diabetic nephropathy in Taiwanese patients with T2D.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with MTHFS cdna clone

 Reference Product  PubMed Publications
 MTHFR cdna clone  >5 publications with MTHFS and MTHFR
 TYMS cdna clone  >3 publications with MTHFS and TYMS
 SHMT1 cdna clone  >2 publications with MTHFS and SHMT1
 MTHFD1 cdna clone  >2 publications with MTHFS and MTHFD1

Pathways associated with MTHFS cdna clone

 Products by Pathway  Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 One Carbon Metabolism Pathway antibodies  One Carbon Metabolism Pathway Diagram
 One Carbon Pool By Folate Pathway antibodies  One Carbon Pool By Folate Pathway Diagram
 One Carbon Pool By Folate Pathway antibodies  One Carbon Pool By Folate Pathway Diagram

Organs/Tissues associated with MTHFS cdna clone

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >1 publications with MTHFS and Lung
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