Human MUT cDNA Clone Expression Plasmid – Cat# MBS1268868

MUT cDNA Clone – Methylmalonyl Coenzyme A Mutase (Human)

Name: MUT cDNA Clone; Methylmalonyl Coenzyme A Mutase; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1268868
Price: 845 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1268868

MBS1268868 is a cDNA clone targeting MUT. More details

$845 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MUT, cDNA Clone

Full Product Name

MUT cDNA Clone

Product Gene Name

MUT cdna clone

Sequence

atgttaagag ctaagaatca gcttttttta ctttcacctc attacctgag gcaggtaaaa gaatcatcag gctccaggct catacagcaa cgacttctac accagcaaca gccccttcac ccagaatggg ctgccctggc taaaaagcag ctgaaaggca aaaacccaga agacctaata tggcacaccc cggaagggat ctctataaaa cccttgtatt ccaagagaga tactatggac ttacctgaag aacttccagg agtgaagcca ttcacacgtg gaccatatcc taccatgtat acctttaggc cctggaccat ccgccagtat gctggtttta gtactgtgga agaaagcaat aagttctata aggacaacat taaggctggt cagcagggat tatcagttgc ctttgatctg gcgacacatc gtggctatga ttcagacaac cctcgagttc gtggtgatgt tggaatggct ggagttgcta ttgacactgt ggaagatacc aaaattcttt ttgatggaat tcctttagaa aaaatgtcag tttccatgac tatgaatgga gcagttattc cagttcttgc aaattttata gtaactggag aagaacaagg tgtacctaaa gagaaactta ctggtaccat ccaaaatgat atactaaagg aatttatggt tcgaaataca tacatttttc ctccagaacc atccatgaaa attattgctg acatatttga atatacagca aagcacatgc caaaatttaa ttcaatttca attagtggat accatatgca ggaagcaggg gctgatgcca ttctggagct ggcctatact ttagcagatg gattggagta ctctagaact ggactccagg ctggcctgac aattgatgaa tttgcaccaa ggttgtcttt cttctgggga attggaatga atttctatat ggaaatagca aagatgagag ctggtagaag actctgggct cacttaatag agaaaatgtt tcagcctaaa aactcaaaat ctcttcttct aagagcacac tgtcagacat ctggatggtc acttactgag caggatccct acaataatat tgtccgtact gcaatagaag caatggcagc agtatttgga gggactcagt ctttgcacac aaattctttt gatgaagctt tgggtttgcc aactgtgaaa agtgctcgaa ttgccaggaa cacacaaatc atcattcaag aagaatctgg gattcccaaa gtggctgatc cttggggagg ttcttacatg atggaatgtc tcacaaatga tgtttatgat gctgctttaa agctcattaa tgaaattgaa gaaatgggtg gaatggccaa agctgtagct gagggaatac ctaaacttcg aattgaagaa tgtgctgccc gaagacaagc tagaatagat tctggttctg aagtaattgt tggagtaaat aagtaccagt tggaaaaaga agacactgta gaagttctgg caattgataa tacttcagtg cgaaacaggc agattgaaaa acttaagaag atcaaatcca gcagggatca agctttggct gaacgttgtc ttgctgcact aaccgaatgt gctgctagcg gagatggaaa tatcctggct cttgcagtgg atgcatctcg ggcaagatgt acagtgggag aaatcacaga tgccctgaaa aaggtatttg gtgaacataa agcgaatgat cgaatggtga gtggagcata tcgccaggaa tttggagaaa gtaaagagat aacatctgct atcaagaggg ttcataaatt catggaacgt gaaggtcgca gacctcgtct tcttgtagca aaaatgggac aagatggcca tgacagagga gcaaaagtta ttgctacagg atttgctgat cttggttttg atgtggacat aggccctctt ttccagactc ctcgtgaagt ggcccagcag gctgtggatg cggatgtgca tgctgtgggc gtaagcaccc tcgctgctgg tcataaaacc ctagttcctg aactcatcaa agaacttaac tcccttggac ggccagatat tcttgtcatg tgtggagggg tgataccacc tcaggattat gaatttctgt ttgaagttgg tgtttccaat gtatttggtc ctgggactcg aattccaaag gctgccgttc aggtgcttga tgatattgag aagtgtttgg aaaagaagca gcaatctgta taa

Molecular Weight

83,134 Da

OMIM

251000

Vector

Please Inquire

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of MUT cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MUT. It may not necessarily be applicable to this product.

NCBI GI #

16740838

NCBI GeneID

4594

NCBI Accession #

BC016282

UniProt Secondary Accession #

Q5SYZ3; Q96B11; Q9UD64; A8K953

UniProt Related Accession #

P22033

NCBI Official Full Name

Homo sapiens methylmalonyl Coenzyme A mutase, mRNA

NCBI Official Synonym Full Names

methylmalonyl-CoA mutase

NCBI Official Symbol

MUT

NCBI Official Synonym Symbols

MCM

UniProt Protein Name

Methylmalonyl-CoA mutase, mitochondrial

UniProt Synonym Protein Names

Methylmalonyl-CoA isomerase

Protein Family

Mutanase

UniProt Gene Name

MUT

UniProt Synonym Gene Names

MCM

UniProt Entry Name

MUTA_HUMAN

NCBI Protein Information

methylmalonyl-CoA mutase, mitochondrial

NCBI Summary for MUT

This gene encodes the mitochondrial enzyme methylmalonyl Coenzyme A mutase. In humans, the product of this gene is a vitamin B12-dependent enzyme which catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA, while in other species this enzyme may have different functions. Mutations in this gene may lead to various types of methylmalonic aciduria. [provided by RefSeq, Jul 2008]

UniProt Comments for MUT

MUT: Involved in the degradation of several amino acids, odd- chain fatty acids and cholesterol via propionyl-CoA to the tricarboxylic acid cycle. MCM has different functions in other species. Defects in MUT are the cause of methylmalonic aciduria type mut (MMAM). MMAM is an often fatal disorder of organic acid metabolism. Common clinical features include lethargy, vomiting, failure to thrive, hypotonia, neurological deficit and early death. Two forms of the disease are distinguished by the presence (mut-) or absence (mut0) of residual enzyme activity. Mut0 patients have more severe neurological manifestations of the disease than do MUT- patients. MMAM is unresponsive to vitamin B12 therapy. Belongs to the methylmalonyl-CoA mutase family.

Protein type: Isomerase; Mitochondrial; Carbohydrate Metabolism - propanoate; EC 5.4.99.2; Amino Acid Metabolism - valine, leucine and isoleucine degradation

Chromosomal Location of Human Ortholog: 6p12.3

Cellular Component: mitochondrial matrix; mitochondrion

Biological Process: cobalamin metabolic process; homocysteine metabolic process; short-chain fatty acid catabolic process

Disease: Methylmalonic Aciduria Due To Methylmalonyl-coa Mutase Deficiency

Research Articles on MUT

1. In methylmalonic acidemia,a total of 10 novel MUT mutations were detected in the Chinese population. c.729_730insTT (p.D244Lfs*39) was the most frequent mutation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with MUT cdna clone

Products by Pathway	Pathway Diagram
2-oxobutanoate Degradation I Pathway antibodies	2-oxobutanoate Degradation I Pathway Diagram
Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies	Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
Glyoxylate And Dicarboxylate Metabolism Pathway antibodies	Glyoxylate And Dicarboxylate Metabolism Pathway Diagram
Glyoxylate And Dicarboxylate Metabolism Pathway antibodies	Glyoxylate And Dicarboxylate Metabolism Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Lipids And Lipoproteins Pathway antibodies	Metabolism Of Lipids And Lipoproteins Pathway Diagram
Mitochondrial Fatty Acid Beta-Oxidation Pathway antibodies	Mitochondrial Fatty Acid Beta-Oxidation Pathway Diagram
Propanoate Metabolism Pathway antibodies	Propanoate Metabolism Pathway Diagram
Propanoate Metabolism Pathway antibodies	Propanoate Metabolism Pathway Diagram
Propionyl-CoA Catabolism Pathway antibodies	Propionyl-CoA Catabolism Pathway Diagram

Diseases associated with MUT cdna clone

Disease Name	Pubmed Publications
Metabolism, Inborn Errors Antibodies	>88 publications with MUT and Metabolism, Inborn Errors
Methylmalonic acidemia Antibodies	>61 publications with MUT and Methylmalonic acidemia
Disease Models, Animal Antibodies	>44 publications with MUT and Disease Models, Animal
Drug Toxicity Antibodies	>28 publications with MUT and Drug Toxicity
Necrosis Antibodies	>27 publications with MUT and Necrosis
Kidney Diseases Antibodies	>26 publications with MUT and Kidney Diseases
Cell Transformation, Neoplastic Antibodies	>22 publications with MUT and Cell Transformation, Neoplastic
Heart Diseases Antibodies	>22 publications with MUT and Heart Diseases
Inflammation Antibodies	>22 publications with MUT and Inflammation
Liver Diseases Antibodies	>20 publications with MUT and Liver Diseases

Organs/Tissues associated with MUT cdna clone

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>235 publications with MUT and Blood
Brain Antibodies	>107 publications with MUT and Brain
Liver Antibodies	>58 publications with MUT and Liver
Muscle Antibodies	>50 publications with MUT and Muscle
Kidney Antibodies	>49 publications with MUT and Kidney
Bone Antibodies	>48 publications with MUT and Bone
Heart Antibodies	>45 publications with MUT and Heart
Lung Antibodies	>45 publications with MUT and Lung
Vascular Antibodies	>37 publications with MUT and Vascular
Skin Antibodies	>26 publications with MUT and Skin