Human NCOA3 cDNA Clone Expression Plasmid – Cat# MBS1269963

NCOA3 cDNA Clone – Nuclear Receptor Coactivator 3 (Human)

Name: NCOA3 cDNA Clone; Nuclear Receptor Coactivator 3; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1269963
Price: 2165 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1269963

MBS1269963 is a cDNA clone targeting NCOA3. More details

$2165 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +2 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

NCOA3, cDNA Clone

Full Product Name

NCOA3 cDNA Clone

Product Gene Name

NCOA3 cdna clone

Sequence

ATGAGTGGAT TAGGAGAAAA CTTGGATCCA CTGGCCAGTG ATTCACGAAA ACGCAAATTG CCATGTGATA CTCCAGGACA AGGTCTTACC TGCAGTGGTG AAAAACGGAG ACGGGAGCAG GAAAGTAAAT ATATTGAAGA ATTGGCTGAG CTGATATCTG CCAATCTTAG TGATATTGAC AATTTCAATG TCAAACCAGA TAAATGTGCG ATTTTAAAGG AAACAGTAAG ACAGATACGT CAAATAAAAG AGCAAGGAAA AACTATTTCC AATGATGATG ATGTTCAAAA AGCCGATGTA TCTTCTACAG GGCAGGGAGT TATTGATAAA GACTCCTTAG GACCGCTTTT ACTTCAGGCA TTGGATGGTT TCCTATTTGT GGTGAATCGA GACGGAAACA TTGTATTTGT ATCAGAAAAT GTCACACAAT ACCTGCAATA TAAGCAAGAG GACCTGGTTA ACACAAGTGT TTACAATATC TTACATGAAG AAGACAGAAA GGATTTTCTT AAGAATTTAC CAAAATCTAC AGTTAATGGA GTTTCCTGGA CAAATGAGAC CCAAAGACAA AAAAGCCATA CATTTAATTG CCGTATGTTG ATGAAAACAC CACATGATAT TCTGGAAGAC ATAAACGCCA GTCCTGAAAT GCGCCAGAGA TATGAAACAA TGCAGTGCTT TGCCCTGTCT CAGCCACGAG CTATGATGGA GGAAGGGGAA GATTTGCAAT CTTGTATGAT CTGTGTGGCA CGCCGCATTA CTACAGGAGA AAGAACATTT CCATCAAACC CTGAGAGCTT TATTACCAGA CATGATCTTT CAGGAAAGGT TGTCAATATA GATACAAATT CACTGAGATC CTCCATGAGG CCTGGCTTTG AAGATATAAT CCGAAGGTGT ATTCAGAGAT TTTTTAGTCT AAATGATGGG CAGTCATGGT CCCAGAAACG TCACTATCAA GAAGCTTATC TTAATGGCCA TGCAGAAACC CCAGTATATC GATTCTCGTT GGCTGATGGA ACTATAGTGA CTGCACAGAC AAAAAGCAAA CTCTTCCGAA ATCCTGTAAC AAATGATCGA CATGGCTTTG TCTCAACCCA CTTCCTTCAG AGAGAACAGA ATGGATATAG ACCAAACCCA AATCCTGTTG GACAAGGGAT TAGACCACCT ATGGCTGGAT GCAACAGTTC GGTAGGCGGC ATGAGTATGT CGCCAAACCA AGGCTTACAG ATGCCGAGCA GCAGGGCCTA TGGCTTGGCA GACCCTAGCA CCACAGGGCA GATGAGTGGA GCTAGGTATG GGGGTTCCAG TAACATAGCT TCATTGACCC CTGGGCCAGG CATGCAATCA CCATCTTCCT ACCAGAACAA CAACTATGGG CTCAACATGA GTAGCCCCCC ACATGGGAGT CCTGGTCTTG CCCCAAACCA GCAGAATATC ATGATTTCTC CTCGTAATCG TGGGAGTCCA AAGATAGCCT CACATCAGTT TTCTCCTGTT GCAGGTGTGC ACTCTCCCAT GGCATCTTCT GGCAATACTG GGAACCACAG CTTTTCCAGC AGCTCTCTCA GTGCCCTGCA AGCCATCAGT GAAGGTGTGG GGACTTCCCT TTTATCTACT CTGTCATCAC CAGGCCCCAA ATTGGATAAC TCTCCCAATA TGAATATTAC CCAACCAAGT AAAGTAAGCA ATCAGGATTC CAAGAGTCCT CTGGGCTTTT ATTGCGACCA AAATCCAGTG GAGAGTTCAA TGTGTCAGTC AAATAGCAGA GATCACCTCA GTGACAAAGA AAGTAAGGAG AGCAGTGTTG AGGGGGCAGA GAATCAAAGG GGTCCTTTGG AAAGCAAAGG TCATAAAAAA TTACTGCAGT TACTTACCTG TTCTTCTGAT GACCGGGGTC ATTCCTCCTT GACCAACTCC CCCCTAGATT CAAGTTGTAA AGAATCTTCT GTTAGTGTCA CCAGCCCCTC TGGAGTCTCC TCCTCTACAT CTGGAGGAGT ATCCTCTACA TCCAATATGC ATGGGTCACT GTTACAAGAG AAGCACCGGA TTTTGCACAA GTTGCTGCAG AATGGGAATT CACCAGCTGA GGTAGCCAAG ATTACTGCAG AAGCCACTGG GAAAGACACC AGCAGTATAA CTTCTTGTGG GGACGGAAAT GTTGTCAAGC AGGAGCAGCT AAGTCCTAAG AAGAAGGAGA ATAATGCACT TCTTAGATAC CTGCTGGACA GGGATGATCC TAGTGATGCA CTCTCTAAAG AACTACAGCC CCAAGTGGAA GGAGTGGATA ATAAAATGAG TCAGTGCACC AGCTCCACCA TTCCTAGCTC AAGTCAAGAG AAAGACCCTA AAATTAAGAC AGAGACAAGT GAAGAGGGAT CTGGAGACTT GGATAATCTA GATGCTATTC TTGGTGATCT GACTAGTTCT GACTTTTACA ATAATTCCAT ATCCTCAAAT GGTAGTCATC TGGGGACTAA GCAACAGGTG TTTCAAGGAA CTAATTCTCT GGGTTTGAAA AGTTCACAGT CTGTGCAGTC TATTCGTCCT CCATATAACC GAGCAGTGTC TCTGGATAGC CCTGTTTCTG TTGGCTCAAG TCCTCCAGTA AAAAATATCA GTGCTTTCCC CATGTTACCA AAGCAACCCA TGTTGGGTGG GAATCCAAGA ATGATGGATA GTCAGGAAAA TTATGGCTCA AGTATGGGTG GGCCAAACCG AAATGTGACT GTGACTCAGA CTCCTTCCTC AGGAGACTGG GGCTTACCAA ACTCAAAGGC CGGCAGAATG GAACCTATGA ATTCAAACTC CATGGGAAGA CCAGGAGGAG ATTATAATAC TTCTTTACCC AGACCTGCAC TGGGTGGCTC TATTCCCACA TTGCCTCTTC GGTCTAATAG CATACCAGGT GCGAGACCAG TATTGCAACA GCAGCAGCAG ATGCTTCAAA TGAGGCCTGG TGAAATCCCC ATGGGAATGG GGGCTAATCC CTATGGCCAA GCAGCAGCAT CTAACCAACT GGGTTCCTGG CCCGATGGCA TGTTGTCCAT GGAACAAGTT TCTCATGGCA CTCAAAATAG GCCTCTTCTT AGGAATTCCC TGGATGATCT TGTTGGGCCA CCTTCCAACC TGGAAGGCCA GAGTGACGAA AGAGCATTAT TGGACCAGCT GCACACTCTT CTCAGCAACA CAGATGCCAC AGGCCTGGAA GAAATTGACA GAGCTTTGGG CATTCCTGAA CTTGTCAATC AGGGACAGGC ATTAGAGCCC AAACAGGATG CTTTCCAAGG CCAAGAAGCA GCAGTAATGA TGGATCAGAA GGCAGGATTA TATGGACAGA CATACCCAGC ACAGGGGCCT CCAATGCAAG GAGGCTTTCA TCTTCAGGGA CAATCACCAT CTTTTAACTC TATGATGAAT CAGATGAACC AGCAAGGCAA TTTTCCTCTC CAAGGAATGC ACCCACGAGC CAACATCATG AGACCCCGGA CAAACACCCC CAAGCAACTT AGAATGCAGC TTCAGCAGAG GCTGCAGGGC CAGCAGTTTT TGAATCAGAG CCGACAGGCA CTTGAATTGA AAATGGAAAA CCCTACTGCT GGTGGTGCTG CGGTGATGAG GCCTATGATG CAGCCCCAGC AGGGTTTTCT TAATGCTCAA ATGGTCGCCC AACGCAGCAG AGAGCTGCTA AGTCATCACT TCCGACAACA GAGGGTGGCT ATGATGATGC AGCAGCAGCA GCAGCAGCAA CAGCAGCAGC AGCAGCAGCA GCAGCAGCAA CAGCAACAGC AACAGCAACA GCAGCAACAG CAGCAAACCC AGGCCTTCAG CCCACCTCCT AATGTGACTG CTTCCCCCAG CATGGATGGG CTTTTGGCAG GACCCACAAT GCCACAAGCT CCTCCGCAAC AGTTTCCATA TCAACCAAAT TATGGAATGG GACAACAACC AGATCCAGCC TTTGGTCGAG TGTCTAGTCC TCCCAATGCA ATGATGTCGT CAAGAATGGG TCCCTCCCAG AATCCCATGA TGCAACACCC GCAGGCTGCA TCCATCTATC AGTCCTCAGA AATGAAGGGC TGGCCATCAG GAAATTTGGC CAGGAACAGC TCCTTTTCCC AGCAGCAGTT TGCCCACCAG GGGAATCCTG CAGTGTATAG TATGGTGCAC ATGAATGGCA GCAGTGGTCA CATGGGACAG ATGAACATGA ACCCCATGCC CATGTCTGGC ATGCCTATGG GTCCTGATCA GAAATACTGC TGA

Molecular Weight

154,892 Da

OMIM

601937

Vector

pUC

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of NCOA3 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for NCOA3. It may not necessarily be applicable to this product.

NCBI GI #

111598959

NCBI GeneID

8202

NCBI Accession #

BC119001

UniProt Secondary Accession #

Q0VF45; Q5JYD9; Q5JYE0; Q9BR49; Q9UPC9; Q9UPG4; Q9UPG7; A4LAZ5

UniProt Related Accession #

Q9Y6Q9

NCBI Official Full Name

Homo sapiens nuclear receptor coactivator 3, mRNA

NCBI Official Synonym Full Names

nuclear receptor coactivator 3

NCBI Official Symbol

NCOA3

NCBI Official Synonym Symbols

ACTR; AIB1; RAC3; SRC3; pCIP; AIB-1; CTG26; SRC-3; CAGH16; KAT13B; TNRC14; TNRC16; TRAM-1; bHLHe42

UniProt Protein Name

Nuclear receptor coactivator 3

UniProt Synonym Protein Names

ACTR; Amplified in breast cancer 1 protein; AIB-1; CBP-interacting protein; pCIP; Class E basic helix-loop-helix protein 42; bHLHe42; Receptor-associated coactivator 3; RAC-3; Steroid receptor coactivator protein 3; SRC-3; Thyroid hormone receptor activator molecule 1; TRAM-1

Protein Family

Nuclear receptor coactivator

UniProt Gene Name

NCOA3

UniProt Synonym Gene Names

AIB1; BHLHE42; RAC3; TRAM1; NCoA-3; AIB-1; pCIP; bHLHe42; RAC-3; SRC-3; TRAM-1

UniProt Entry Name

NCOA3_HUMAN

NCBI Protein Information

nuclear receptor coactivator 3

NCBI Summary for NCOA3

The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq, Mar 2010]

UniProt Comments for NCOA3

SRC-3: a histone acetyltransferase and nuclear receptor coactivator. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. Activity is enhanced by various hormones and TNF. Acetylation by CREBBP may suppress coactivation of target genes by disrupting its association with nuclear receptors. Frequently amplified or overexpressed in breast and ovarian cancers. Five alternatively spliced isoforms have been described.

Protein type: EC 2.3.1.48; Motility/polarity/chemotaxis; Transcription, coactivator/corepressor; Acetyltransferase; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 20q12

Cellular Component: cytoplasm; nuclear chromatin; nucleoplasm; nucleus

Molecular Function: histone acetyltransferase activity; ligand-dependent nuclear receptor binding; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; protein binding; protein N-terminus binding; transcription coactivator activity

Biological Process: intracellular receptor-mediated signaling pathway; positive regulation of keratinocyte differentiation; positive regulation of transcription from RNA polymerase II promoter

Research Articles on NCOA3

1. The transcriptional coactivator SRC-3.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with NCOA3 cdna clone

Products by Pathway	Pathway Diagram
Androgen Receptor Signaling Pathway antibodies	Androgen Receptor Signaling Pathway Diagram
Developmental Biology Pathway antibodies	Developmental Biology Pathway Diagram
FOXA1 Transcription Factor Network Pathway antibodies	FOXA1 Transcription Factor Network Pathway Diagram
Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies	Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
Integrated Breast Cancer Pathway antibodies	Integrated Breast Cancer Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Lipids And Lipoproteins Pathway antibodies	Metabolism Of Lipids And Lipoproteins Pathway Diagram
PPARA Activates Gene Expression Pathway antibodies	PPARA Activates Gene Expression Pathway Diagram
Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway antibodies	Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway Diagram
Retinoic Acid Receptors-mediated Signaling Pathway antibodies	Retinoic Acid Receptors-mediated Signaling Pathway Diagram

Diseases associated with NCOA3 cdna clone

Disease Name	Pubmed Publications
Neoplasms Antibodies	>157 publications with NCOA3 and Neoplasms
Breast Neoplasms Antibodies	>107 publications with NCOA3 and Breast Neoplasms
Adenocarcinoma Antibodies	>24 publications with NCOA3 and Adenocarcinoma
Neoplasms, Experimental Antibodies	>16 publications with NCOA3 and Neoplasms, Experimental
Prostatic Neoplasms Antibodies	>15 publications with NCOA3 and Prostatic Neoplasms
Disease Models, Animal Antibodies	>11 publications with NCOA3 and Disease Models, Animal
Ovarian Neoplasms Antibodies	>11 publications with NCOA3 and Ovarian Neoplasms
Inflammation Antibodies	>10 publications with NCOA3 and Inflammation
Hyperplasia Antibodies	>9 publications with NCOA3 and Hyperplasia
Liver Diseases Antibodies	>9 publications with NCOA3 and Liver Diseases

Organs/Tissues associated with NCOA3 cdna clone

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>25 publications with NCOA3 and Blood
Liver Antibodies	>25 publications with NCOA3 and Liver
Prostate Antibodies	>22 publications with NCOA3 and Prostate
Thyroid Antibodies	>17 publications with NCOA3 and Thyroid
Lymph Antibodies	>16 publications with NCOA3 and Lymph
Lymph Node Antibodies	>16 publications with NCOA3 and Lymph Node
Lung Antibodies	>14 publications with NCOA3 and Lung
Mammary Gland Antibodies	>14 publications with NCOA3 and Mammary Gland
Muscle Antibodies	>14 publications with NCOA3 and Muscle
Uterus Antibodies	>14 publications with NCOA3 and Uterus