NDEL1 cDNA Clone – Nude Nuclear Distribution Gene E Homolog (A. Nidulans)-Like 1 (Human)

This gene encodes a coiled-coil protein that plays a role in multiple processes including cytoskeletal organization, cell signaling and neuron migration, outgrowth and maintenance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, Mar 2012]

NDEL1: Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Belongs to the nudE family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Protease; Microtubule-binding

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: centrosome; cytosol; kinesin complex; kinetochore

Molecular Function: microtubule binding; protein binding

Biological Process: cell migration; centrosome localization; chromosome segregation; establishment of chromosome localization; establishment of mitotic spindle orientation; microtubule nucleation; mitotic centrosome separation; positive regulation of GTPase activity; regulation of intracellular protein transport; sister chromatid cohesion; vesicle transport along microtubule